Tygacil Inj 1 Vial

Tigecycline, a semi-synthetic tetracycline derivative, exerts its antibacterial activity through multiple mechanisms. Primarily, it binds to the 30S ribosomal subunit, inhibiting protein translation by preventing the binding of aminoacyl-tRNA to the ribosomal acceptor (A) site. This binding interferes with the entry of aminoacyl-tRNA into the A site, thus disrupting bacterial protein synthesis. Additionally, tigecycline has the ability to inhibit the translation of specific genes involved in bacterial virulence and resistance, further contributing to its antimicrobial effect. Its broad-spectrum activity encompasses many gram-positive and gram-negative bacteria, including those resistant to other antibiotics, due to its unique binding properties on the ribosome.

Glycylcycline antibiotic

Injection

The following are the uses of Tigecycline Injection:

• Used for treating complicated skin and skin structure infections caused by specific bacteria.
• Used for managing complicated intra-abdominal infections when other antibiotics are not suitable.
• Used as a last-resort treatment for complicated infections due to its effectiveness against antibiotic-resistant bacteria.
• Used to combat bacterial infections that are resistant to other antibiotics.
• Used in situations where other antibiotics have failed, especially for severe infections.
• Used to treat community-acquired pneumonia, especially in patients with underlying health conditions.
• Used in the treatment of hospital-acquired pneumonia caused by susceptible pathogens.

In the case of an overdose of Tigecycline Injection, immediate medical intervention is necessary. Symptoms may include an increased risk of adverse reactions, particularly affecting the gastrointestinal system, such as nausea, vomiting, and diarrhea. Additionally, an overdose could potentially lead to more severe complications, such as an imbalance in the body's natural bacterial flora, which may result in the overgrowth of opportunistic pathogens. Prompt medical care should be sought to manage these symptoms and prevent further complications.

In the case of a missed dose of Tigecycline Injection, it is important to administer the missed dose as soon as possible. However, if it is almost time for the next scheduled dose, it is best to skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare professional for guidance on how to resume the medication safely. It is crucial to maintain a consistent medication routine to ensure the effectiveness of the treatment.

To administer Tigecycline Injection, gently swirl the vial to ensure the powder is loose, reconstitute the powder with the provided sterile diluent, and inject the prescribed dose intravenously over 30-60 minutes, following the instructions provided by your healthcare professional.

Here are the conditions or situations when Tigecycline Injection should not be used:

• Should not be used in patients with a known allergy or hypersensitivity to Tigecycline or any tetracycline antibiotics.
• Contraindicated in patients with severe liver impairment or active liver disease.
• Not recommended for children and adolescents under 18 years of age, as the safety and efficacy have not been established in this age group.
• Should not be used during pregnancy or breastfeeding due to potential risks to the fetus and infant.
• Avoid using in patients with a history of Clostridium difficile-associated diarrhea or antibiotic-associated colitis.
• Tigecycline is not indicated for the treatment of viral infections, such as the common cold or flu.
• Should not be used in patients with a history of severe renal impairment (kidney disease) without adjusting the dose.

The side effects of Tigecycline Injection may include:

• Nausea and vomiting
• Diarrhea
• Dizziness
• Skin rash or itching
• Headache
• Increased sensitivity to sunlight
• Changes in liver function
• Tooth discoloration

Following are the precautions and warnings:

• Tigecycline Injection should not be used in patients with known allergies or hypersensitivity to tigecycline or any of its components. Severe allergic reactions may occur.
• This medication is not recommended for children and adolescents under 18 years of age due to potential bone and tooth development issues.
• Tigecycline should be used with caution in patients with liver or kidney disease, as dosage adjustments may be necessary.
• Patients with a history of Clostridium difficile-associated diarrhea or other gastrointestinal disorders should be monitored for the development of severe diarrhea during and after treatment.
• It may cause photosensitivity, so patients should limit sun exposure and use protective measures when outdoors.
• Tigecycline should be used with caution in patients with a history of seizures or those taking medications that lower the seizure threshold.
• Patients with diabetes should be aware that tigecycline may cause false-positive results on certain urine glucose tests.

Following are the drug interactions for Tigecycline Injection:

• Concomitant use with drugs that prolong the QT interval (e.g., Class IA and III antiarrhythmics, certain antipsychotics, and some antibiotics) may increase the risk of cardiac arrhythmias.
• Tigecycline may reduce the effectiveness of oral contraceptives, requiring the use of additional contraceptive methods.
• It can decrease the efficacy of warfarin and other vitamin K antagonists, potentially requiring adjustments in dosage.
• The effectiveness of live bacterial vaccines may be diminished when administered concurrently with Tigecycline.
• Increased risk of seizures when used with other medications that lower the seizure threshold, such as certain antidepressants or antipsychotics.
• Tigecycline may decrease the blood levels of oral typhoid vaccine, potentially reducing its effectiveness.
• Co-administration with carbamazepine can result in decreased tigecycline concentrations, potentially reducing its therapeutic effect.

Following are the food interactions to be aware of when taking Tigecycline Injection:

• Avoid consuming grapefruit or grapefruit juice as it may interfere with the metabolism of Tigecycline, potentially leading to increased drug levels in the body.
• Alcohol consumption should be minimized or avoided as it can enhance the risk of side effects and liver toxicity associated with Tigecycline.
• Dairy products like milk, yogurt, and cheese should be consumed with caution as they may decrease the absorption of Tigecycline. Consider separating Tigecycline doses from these products by at least 2-3 hours.
• High-fat meals might impact the absorption of Tigecycline. It is advisable to avoid consuming fatty foods immediately before or after taking the medication.
• Vitamin and mineral supplements, particularly those containing calcium, iron, or magnesium, may interact with Tigecycline. It is best to take these supplements at different times of the day.
• Antacids containing aluminum, magnesium, or calcium may reduce the absorption of Tigecycline. Ensure a 2-hour gap between Tigecycline and antacid intake.
• Avoid herbal supplements without medical advice as some herbs may influence the metabolism of Tigecycline.
• Always consult your healthcare provider for personalized advice regarding food and drug interactions to ensure the safe and effective use of Tigecycline Injection.

Tigecycline Injection should be stored properly to maintain its efficacy and safety. It is recommended to keep the injection in a cool, dry place, preferably between 2°C and 8°C (refrigerator temperature) in its original packaging. Protect the injection from light and moisture to prevent degradation. Do not freeze the medication as it may affect its potency. Always check the expiration date before use and discard any expired or unused vials. For disposal, do not throw away the medication in household trash or flush it down the toilet. Contact your healthcare provider or pharmacist for instructions on safe disposal methods to ensure environmental protection. Keep the injection out of the reach of children and pets to prevent accidental exposure.

Following are the quick tips for Tigecycline Injection:

• Tigecycline injection is typically given once every 12 hours as prescribed by your doctor.
• Ensure you receive this injection at the scheduled time for maximum effectiveness.
• Administer the injection slowly as directed, usually over a period of 30 to 60 minutes.
• Inform your healthcare provider if you have any allergies or have experienced an allergic reaction to similar medications.
• Before starting the medication, discuss any medical conditions, especially liver or kidney problems, with your doctor.
• Tigecycline may make your skin more sensitive to sunlight; avoid prolonged sun exposure and tanning beds.
• Do not reuse or share needles or syringes; dispose of them properly after use.