Ulcerex (400mg) 10 Tablets

Cimetidine primarily exerts its action by blocking histamine H2 receptors in the stomach. It is a potent H2 receptor antagonist, which means it inhibits the action of histamine on specific receptors known as H2 receptors. These receptors are primarily located on the parietal cells in the stomach, which are responsible for producing gastric acid. When Cimetidine binds to these receptors, it leads to a decrease in the secretion of gastric acid. This reduction in acid secretion helps to alleviate conditions such as gastroesophageal reflux disease (GERD), peptic ulcers, and other acid-related disorders by reducing the acidity of the stomach contents and promoting the healing of the gastrointestinal mucosa.

Cimetidine 400mg

H2-receptor antagonist.

Tablet

The following are the uses of Cimetidine 400mg Tablet:

• Used for treating stomach ulcers and reducing stomach acid production.
• Used to manage heartburn and acid reflux symptoms.
• Used for healing and preventing stomach and duodenal ulcers.
• Used to reduce acid reflux, especially in conditions like Gastroesophageal Reflux Disease (GERD).
• Used for managing Zollinger-Ellison syndrome, a rare condition causing excessive stomach acid.
• Used to relieve stomach discomfort and promote healing.
• Used as a supportive treatment for other gastrointestinal issues.

In the case of an overdose of Cimetidine 400mg Tablets, it is important to remain calm and take immediate action. Contact a healthcare professional or a poison control center for guidance. Symptoms of an overdose may include nausea, vomiting, rapid heartbeat, and confusion. Do not induce vomiting unless advised by a medical professional, as it may worsen the situation. Prompt medical attention can help manage the effects of an overdose and ensure the best possible outcome.

In the case of a missed dose of Cimetidine 400mg Tablet, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss multiple doses, consult your healthcare provider for guidance on how to safely resume your medication and adjust your dosing schedule if necessary. It is important to maintain a consistent dosing routine for the medication's effectiveness.

To take Cimetidine 400mg Tablets, swallow the tablet whole with a full glass of water, following the prescribed dosage as directed by your healthcare professional, typically taken once or twice a day, either without regard to meals or before bedtime on an empty stomach.

Here are the conditions and situations when Cimetidine 400mg Tablet should not be used:

• Avoid using Cimetidine if you have a known allergy or hypersensitivity to the drug or other H2-receptor antagonists.
• Do not take this medication if you have a history of severe liver disease or kidney disease.
• It is contraindicated in patients with acute porphyria, a rare metabolic disorder.
• Should not be used in individuals with a slow heart rate (bradycardia) or heart block.
• Not recommended for patients with a history of low blood cell counts (bone marrow depression).
• Avoid using Cimetidine if you have a stomach ulcer with bleeding or a blockage in the stomach or intestines.
• Do not use this medication if you are breastfeeding, as it may pass into breast milk.
• Cimetidine should not be given to children or adolescents without medical advice.

The side effects of Cimetidine 400mg Tablet may include:

• Diarrhea
• Nausea and vomiting
• Dry mouth
• Fatigue and drowsiness
• Confusion, especially in elderly patients
• Skin rashes or itching
• Headache
• Joint pain

Following are the precautions and warnings for Cimetidine 400mg Tablet:

• Avoid in patients with a known hypersensitivity or allergy to Cimetidine or other H2-receptor antagonists.
• Use with caution in patients with kidney or liver impairment, as dosage adjustments may be necessary.
• Cimetidine may interact with other medications, including phenytoin, warfarin, and theophylline, so close monitoring is required when used concomitantly.
• Avoid alcohol consumption while taking Cimetidine, as it may increase the risk of side effects.
• Patients with a history of porphyria should use Cimetidine with caution, as it may trigger an attack.
• Not recommended for use during pregnancy or breastfeeding unless the potential benefits outweigh the risks.
• Elderly patients may be more susceptible to side effects, and dosage adjustments might be needed.

Following are the drug interactions for Cimetidine 400mg Tablet:

• Cimetidine can increase blood levels of warfarin, phenytoin, and lidocaine, leading to potential toxicity.
• It may reduce the clearance of benzodiazepines, enhancing their sedative effects.
• Antacids containing aluminum or magnesium can decrease the absorption of cimetidine when taken simultaneously.
• The drug may reduce the elimination of theophylline, leading to potential theophylline toxicity.
• Cimetidine can inhibit the metabolism of various medications, including beta-blockers, calcium channel blockers, and some antidepressants, potentially requiring dose adjustments.
• It may decrease the effectiveness of certain medications like metformin and glyburide used in diabetes management.
• Caution is advised with drugs that are metabolized by the liver's cytochrome P450 enzymes, as cimetidine can affect their metabolism.

Following are the food interactions for Cimetidine 400mg Tablet:

• Alcohol consumption should be avoided as it may increase the risk of side effects, particularly in the central nervous system, and can also reduce the breakdown of Cimetidine, leading to higher drug levels in the body.
• Grapefruit and grapefruit juice should be consumed with caution as they may increase Cimetidine levels in the blood by inhibiting the enzyme CYP450, potentially leading to increased side effects.
• Caffeine-containing beverages like coffee, tea, and energy drinks should be limited as Cimetidine can increase caffeine levels in the body, resulting in heightened alertness, anxiety, and difficulty sleeping.
• High-fat meals may slow down the absorption of Cimetidine, delaying its onset of action. It is advisable to take the medication on an empty stomach or with a light meal.
• Avoid eating large amounts of chocolate, especially dark chocolate, as it contains a compound called theobromine, which can interact with Cimetidine and potentially lead to increased side effects.
• Foods rich in Vitamin C, such as citrus fruits and broccoli, may enhance the absorption of Cimetidine, possibly increasing its effectiveness.
• Dairy products, particularly milk, may decrease the absorption of Cimetidine. It is best to take the medication at least one hour before or two hours after consuming milk.
• Salt substitutes containing potassium should be used cautiously, as Cimetidine can increase potassium levels in the body, potentially leading to hyperkalemia, especially in patients with kidney issues.

Cimetidine 400mg Tablets should be stored in a dry and cool place, preferably at room temperature (around 20-25°C). Protect the tablets from excessive heat, moisture, and direct sunlight as these conditions can degrade the medication. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent exposure to air and humidity. When disposing of unused or expired tablets, do not flush them down the toilet or throw them into the trash. Instead, follow local guidelines for pharmaceutical waste disposal or consult a pharmacist for safe disposal methods. It is crucial to keep the medication away from children and pets to prevent accidental consumption, which may be harmful.

Following are the quick tips for Cimetidine 400mg Tablet:

• Consult a doctor or pharmacist for personalized advice before taking this medication.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• Take the tablet on an empty stomach, at least 1 hour before or 2 hours after meals.
• Avoid alcohol consumption while taking this medication as it may reduce its effectiveness.
• Inform your doctor about all medications you are currently taking to prevent potential interactions.
• Do not take more than the prescribed dose, and complete the full course of treatment.
• Store the medication at room temperature, away from moisture and direct sunlight.
• Contact your doctor if you experience any unusual symptoms or if your condition doesn't improve.