ULCEREX INJ

ULCEREX INJ

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  • Manufacturer SAMI Pharmaceuticals (Pvt.) Ltd.
  • Generic Name

    cimetidine

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4.9/ 5
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Product Information

  • Description
  • Ingredients
  • Drug Class
  • Dosage Form
  • Uses
  • In case of Overdose
  • Missed Dose
  • How To Use
  • When Not to Use
  • Side Effects
  • Precautions & Warnings
  • Drug Interactions
  • Food Interactions
  • Storage/Disposal
  • Quick Tips, if any
  • Description

    Cimetidine's primary mechanism of action is to inhibit hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), also known as the gastric proton pump, which is responsible for the final step of gastric acid secretion. By blocking this pump, cimetidine suppresses gastric acid production. It competitively inhibits histamine at the H2 receptor level, reducing the production of gastric acid. This action provides relief from acid-related conditions as it decreases gastric acidity and increases gastric pH, thereby reducing the activity of pepsin, an enzyme that requires a highly acidic environment to function optimally. Additionally, cimetidine has a cytoprotective effect, promoting the healing of gastrointestinal lesions.

  • Ingredients

    cimetidine

  • Drug Class

    Histamine-2 receptor antagonist.

  • Dosage Form

    Injection

  • Uses

    The following are the uses of cimetidine Injection:

    • Used for treating peptic ulcers and gastroesophageal reflux disease (GERD)
    • Used for reducing stomach acid production and promoting ulcer healing
    • Used for managing heartburn and acid indigestion symptoms
    • Used for preventing and treating stomach ulcers caused by NSAIDs
    • Used for treating Zollinger-Ellison syndrome, a rare condition causing excess acid production
    • Used for improving survival rates after a heart attack (off-label use)
    • Used for reducing the risk of gastrointestinal bleeding in critically ill patients
  • In case of Overdose

    In the case of an overdose of Cimetidine Injection, it is important to recognize the potential signs and symptoms, which may include severe drowsiness, confusion, and abnormal heart rhythms. Prompt medical intervention is necessary, as the doctor may administer specific treatments to address the overdose, such as activated charcoal or gastric lavage, depending on the severity and timing of the overdose. Close monitoring of vital signs and supportive care are crucial during the management of a cimetidine overdose.

  • Missed Dose

    In the case of a missed dose of cimetidine injection, it is important to administer the medication as soon as you remember. However, if it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses or are unsure about how to proceed, contact your healthcare provider for guidance, as they can provide specific instructions based on your medical condition and treatment plan.

  • How To Use

    To administer cimetidine injection, clean the injection site with an antiseptic, insert the needle at a 90-degree angle, and slowly inject the prescribed dose into the muscle or vein as directed by your healthcare provider, ensuring proper needle disposal and adhering to aseptic techniques.

  • When Not to Use

    Here are the conditions and situations when Cimetidine Injection should not be used:

    • Allergy or hypersensitivity to cimetidine or other H2-receptor antagonists.
    • Patients with severe liver impairment or liver failure, as cimetidine metabolism may be affected.
    • If the patient is already taking medications that significantly lower blood pressure, as cimetidine can also affect blood pressure.
    • Not recommended for patients with a history of porphyria, as it may trigger an attack.
    • Should not be used in patients with renal failure or severe kidney disease.
    • Contraindicated in patients with a slow heart rate (bradycardia) or heart block.
    • Avoid using in patients with a history of lung diseases like asthma or chronic obstructive pulmonary disease (COPD).
    • Not suitable for patients with a history of severe systemic disease or immunodeficiency.
    • Do not use if the patient has a history of gastrointestinal bleeding or obstruction.
  • Side Effects

    The side effects of cimetidine Injection may include:

    • Diarrhea
    • Dizziness
    • Headache
    • Nausea and vomiting
    • Skin rashes or itching
    • Confusion, especially in elderly patients
    • Reduced libido
    • Gynecomastia (enlarged breast tissue in men)
  • Precautions & Warnings

    Following are the precautions and warnings for Cimetidine Injection:

    • Avoid use in patients with known hypersensitivity to cimetidine or any other components of the injection.
    • Use with caution in patients with impaired renal or hepatic function, as they may experience prolonged drug effects due to reduced clearance.
    • Cimetidine may interact with other medications, such as warfarin, phenytoin, or theophylline, altering their effects. Consult a healthcare provider before using with other medications.
    • Caution is required when administering to elderly patients, as they may be more susceptible to side effects, particularly confusion or agitation.
    • Use with caution in patients with a history of gastrointestinal bleeding or ulcers, as cimetidine may mask symptoms or affect gastric pH levels.
    • Prolonged use may lead to vitamin B12 deficiency; regular monitoring may be necessary with long-term use.
    • May cause dizziness or confusion, especially in older adults; advise patients not to drive or operate heavy machinery if these symptoms occur.
    • Should be used with caution in patients with a history of cardiac arrhythmias, as cimetidine can potentially affect heart rate.
    • Pregnant or breastfeeding women should consult a healthcare provider before use, as the drug may pass into breast milk.
    • Overdose may lead to symptoms such as confusion, agitation, and cardiac disturbances; in such cases, seek immediate medical attention.
    • If signs of infection or fever appear, medical attention should be sought immediately, as cimetidine may increase the risk of infections in some patients.
  • Drug Interactions

    Following are the drug interactions for Cimetidine Injection:

    • Cimetidine can increase the effects of warfarin and other anticoagulants, requiring close monitoring of coagulation parameters.
    • It may reduce the clearance of diazepam and other benzodiazepines, leading to enhanced sedative effects.
    • The absorption of tricyclic antidepressants (TCAs) can be decreased, potentially reducing their effectiveness.
    • When used with theophylline, cimetidine can increase theophylline levels, requiring dosage adjustments.
    • Caution is advised with phenytoin as cimetidine may increase its levels, necessitating monitoring for phenytoin toxicity.
    • It can reduce the elimination of lidocaine and other local anesthetics, increasing the risk of side effects.
    • Cimetidine may decrease the effectiveness of antacids and proton pump inhibitors when taken concurrently.
  • Food Interactions

    Following are the food interactions for Cimetidine Injection:

    • Alcohol consumption should be avoided as it may increase the risk of side effects and impair the therapeutic effects of Cimetidine.
    • Grapefruit and grapefruit juice should be consumed with caution as they may alter the metabolism of Cimetidine, potentially increasing its levels in the body and raising the risk of adverse effects.
    • Caffeine-containing beverages like coffee and tea might interfere with Cimetidine's action, reducing its effectiveness.
    • Foods high in tyramine, such as aged cheeses, cured meats, and certain fermented foods, should be limited as Cimetidine may interact with tyramine, leading to elevated blood pressure.
    • Avoid high-sodium foods as Cimetidine may interact with sodium, potentially affecting blood pressure.
    • Avoid excessive consumption of foods rich in vitamin B12, as Cimetidine can interfere with its absorption.
    • Cimetidine may interact with certain spices, such as garlic and turmeric, affecting their metabolism and potentially reducing their effectiveness.
    • Always consult your healthcare provider for personalized advice regarding dietary restrictions and interactions specific to your health condition.
  • Storage/Disposal

    Cimetidine Injection should be stored and disposed of with caution to ensure safety and maintain its integrity. Store the injection at room temperature, between 20-25°C (68-77°F), in a dry place, protected from light and moisture. Keep the medication in its original packaging, tightly sealed, to prevent contamination. Avoid exposure to extreme temperatures, as well as freezing conditions, as this may affect the solution's stability. Always check the expiration date before use and do not use the injection if it is expired. For disposal, do not flush or pour the medication down the drain. Contact your healthcare provider or pharmacist for guidance on proper disposal methods to prevent environmental harm. Keep the injection out of the reach of children and pets to prevent accidental exposure.

  • Quick Tips, if any

    Following are the quick tips for Cimetidine Injection:

    • Administer the injection under medical supervision for safe and effective use.
    • Ensure the injection is prepared and administered by trained medical professionals.
    • Follow the prescribed dosage and administration schedule provided by your healthcare provider.
    • Cimetidine injection can be given intravenously or intramuscularly as directed.
    • Do not inject if the solution appears discolored or contains particles.
    • Rotate injection sites to minimize injection site reactions.
    • Report any adverse reactions or unusual symptoms to your healthcare provider immediately.
    • Store the injection as directed, away from direct sunlight and extreme temperatures.

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