ULTIBRO 110/50MCG CAP

Glycopyrrolate and Indacaterol are the active ingredients in the combination medication. Glycopyrrolate is an anticholinergic agent that blocks the action of acetylcholine at muscarinic receptors, primarily in the airways. By inhibiting these receptors, glycopyrrolate reduces bronchoconstriction and mucus secretion, providing bronchodilation. Indacaterol, on the other hand, is a long-acting beta-2 adrenergic agonist (LABA). It stimulates beta-2 receptors in the airways, leading to smooth muscle relaxation and sustained bronchodilation. By combining these two mechanisms, the medication effectively improves lung function and helps maintain airway patency in patients with respiratory conditions such as chronic obstructive pulmonary disease (COPD).

Glycopyrrolate, Indacaterol

Long-acting beta-agonist (LABA)

Capsule

The following are the uses of Glycopyrrolate, Indacaterol Capsule:

• Used for preventing symptoms of chronic obstructive pulmonary disease (COPD)
• Used to relax the airways and keep them open, making breathing easier
• Used to reduce shortness of breath and wheezing
• Used for long-term maintenance treatment, not for sudden asthma attacks
• Used to decrease the number of flare-ups or exacerbations in COPD patients
• Used to improve overall lung function and quality of life
• Used as a combination medication for better control of COPD symptoms

In the case of an overdose of Glycopyrrolate and Indacaterol Capsule, individuals may experience symptoms such as dry mouth, blurred vision, difficulty urinating, rapid heartbeat, and increased blood pressure. It is crucial to seek medical assistance promptly if an overdose is suspected. Timely intervention can help manage the symptoms and prevent potential complications associated with excessive medication intake. Always follow the prescribed dosage to ensure safety and minimize the risk of adverse effects.

In the case of a missed dose of Glycopyrrolate and Indacaterol Capsule, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication regimen.

To use the Glycopyrrolate, Indacaterol Capsule, remove one capsule from the blister pack and inhale the contents using the provided inhaler device, following the instructions provided by your healthcare provider or pharmacist, ensuring proper inhalation technique for optimal effectiveness.

Following are the conditions/situations when Glycopyrrolate and Indacaterol Capsule should not be used:

• Should not be used in individuals with a known allergy to Glycopyrrolate, Indacaterol, or other similar bronchodilators.
• Contraindicated in patients with narrow-angle glaucoma or a history of glaucoma.
• Not suitable for individuals with a history of urinary retention or difficulty passing urine.
• Should not be used in patients with severe kidney disease or end-stage renal disease.
• Contraindicated in patients with severe liver impairment or cirrhosis.
• Not recommended for individuals with a history of heart problems, such as rapid heart rate, irregular heartbeat, or severe heart disease.
• Should be avoided in patients with a recent heart attack or unstable heart conditions.
• Do not use if you have a condition called paralytic ileus, or severe bowel obstruction.
• Not suitable for individuals with a history of severe allergic reactions or anaphylaxis.

The side effects of Glycopyrrolate, Indacaterol Capsule may include:

• Dry mouth and throat
• Constipation
• Urinary retention
• Blurred vision
• Dizziness or lightheadedness
• Increased heart rate (tachycardia)
• Palpitations
• Allergic reactions (such as rash, itching, or difficulty breathing)

Following are the precautions and warnings for Glycopyrrolate, Indacaterol Capsule:

• This medication is intended for oral inhalation only and should not be swallowed. Ensure proper inhalation technique to maximize drug delivery to the lungs.
• Not recommended for individuals with a history of severe allergies or hypersensitivity to glycopyrrolate or indacaterol.
• Patients with narrow-angle glaucoma or urinary retention should use this medication with caution and under medical supervision.
• May cause paradoxical bronchospasm. Discontinue use if this occurs and seek immediate medical attention.
• Caution in patients with cardiovascular disorders, as this medication may increase heart rate and blood pressure. Regular monitoring is advised.
• Elderly patients may be more susceptible to adverse effects; dosage adjustment might be necessary.
• Not recommended for children and adolescents under 18 years of age due to insufficient data.

Following are the drug interactions for Glycopyrrolate, Indacaterol Capsule:

• Concomitant use with other anticholinergic medications may increase side effects such as dry mouth, blurred vision, and constipation.
• Beta-blockers may interact with Indacaterol, reducing its effectiveness on the heart and lungs.
• Glycopyrrolate can interact with certain medications like atropine, scopolamine, and some antihistamines, leading to increased anticholinergic effects.
• Indacaterol may have reduced absorption when taken with antacids containing aluminum or magnesium.
• Ketoconazole and other strong CYP3A4 inhibitors can increase the concentration of Indacaterol, potentially leading to adverse effects.
• Caution is advised with medications that prolong the QT interval, as Glycopyrrolate may also affect heart rhythm.
• The effectiveness of Indacaterol may be decreased by certain corticosteroids, requiring dosage adjustments.

Following are the food interactions for Glycopyrrolate, Indacaterol Capsule:

• Avoid consuming grapefruit and grapefruit juice as they may interfere with the medication's metabolism, potentially leading to increased side effects.
• Alcohol consumption should be limited as it can cause excessive drowsiness and dizziness, especially when combined with the medication's effects.
• Caffeine intake should be monitored as it may enhance the medication's stimulatory effects, potentially causing increased heart rate and nervousness.
• High-fat meals can delay the absorption of the medication, affecting its onset of action.
• Avoid potassium-rich foods like bananas, oranges, and spinach, as the medication can increase potassium levels, leading to potential health risks.
• Salt substitutes containing potassium should be used with caution as the medication may affect potassium levels in the body.
• Avoid consuming natural licorice as it may interact with the medication, potentially affecting blood pressure and heart rate.
• Always inform your healthcare provider about your dietary habits to ensure the medication's safe and effective use.

Glycopyrrolate, Indacaterol Capsule should be stored in a cool and dry place, preferably at room temperature, ensuring it is kept away from direct sunlight, moisture, and heat sources like ovens or radiators. It is crucial to maintain the medication in its original, tightly sealed container to prevent contamination. Regularly check the expiration date, and if the medication is no longer needed or has expired, proper disposal is essential. Avoid flushing or pouring it down the drain; consult a pharmacist or healthcare professional for guidance on safe disposal methods. Always keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Glycopyrrolate and Indacaterol Capsule:

• Store the capsules in a cool, dry place, away from direct sunlight and moisture.
• Take the capsule as directed by your doctor; do not crush or chew it.
• Ensure you inhale the full dose of the capsule by practicing proper inhalation technique.
• Keep a record of your medication schedule to avoid missing doses.
• Inform your doctor if you have any lung or breathing-related conditions before taking Indacaterol.
• Do not stop taking Glycopyrrolate without consulting your healthcare provider.
• Report any side effects or unusual symptoms to your doctor promptly.