UNASYN 750MG INJ

Ampicillin and Sulbactam Injection is a combination antibiotic that works by interfering with the synthesis of bacterial cell walls. Ampicillin belongs to the penicillin group of antibiotics and acts by inhibiting the transpeptidation process in the formation of the peptidoglycan layer of bacterial cell walls, leading to cell lysis. However, some bacteria produce beta-lactamase, an enzyme that can break down ampicillin and render it ineffective. This is where Sulbactam comes into play; it is a beta-lactamase inhibitor that protects ampicillin from being degraded by this enzyme. Sulbactam binds to and inhibits beta-lactamases, thereby preserving the antibacterial activity of ampicillin against susceptible organisms.

Ampicillin 500mg, Sulbactam 250MG

Penicillin/beta-lactamase inhibitor.

Injection

The following are the uses of Ampicillin 500mg, Sulbactam 250MG Injection:

• Used for treating bacterial infections such as pneumonia, urinary tract infections, and skin and soft tissue infections.
• Used for combating infections caused by susceptible bacteria, including E. coli and H. influenzae.
• Used for inhibiting bacterial cell wall synthesis, weakening the bacteria and preventing their multiplication.
• Used for surgical prophylaxis to prevent infections during and after surgeries.
• Used for treating infections in various body systems, including the respiratory, gastrointestinal, and genitourinary tracts.
• Used for providing a broad spectrum of coverage against both Gram-positive and Gram-negative bacteria.
• Used for reducing the risk of antibiotic resistance when used appropriately and under medical supervision.
• Used for combination therapy with other antibiotics to enhance effectiveness against certain bacterial infections.

In the case of an overdose of Ampicillin 500mg and Sulbactam 250mg Injection, individuals may experience an increase in the severity of common side effects such as nausea, vomiting, diarrhea, and skin rashes. Additionally, an overdose could potentially lead to more serious issues like seizures, allergic reactions, or an imbalance in the body's natural bacteria. It is important to seek medical advice promptly and provide the necessary information regarding the dosage and timing of the overdose.

In the case of a missed dose of Ampicillin 500mg, Sulbactam 250mg Injection, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for further guidance on how to adjust your medication regimen. It is advisable to set reminders or alarms to help you remember to take your medication on time.

To administer Ampicillin 500mg and Sulbactam 250mg Injection, draw the medication into a syringe and inject it intravenously or intramuscularly as directed by your healthcare provider, ensuring proper aseptic technique and following the prescribed dosage and administration schedule provided by your doctor.

Here are the conditions and situations when Ampicillin 500mg, Sulbactam 250mg Injection should not be used:

• Avoid if you have a known allergy to Ampicillin, Sulbactam, or any penicillin-type antibiotics.
• Do not use if you have a history of severe allergic reactions to any beta-lactam antibiotics.
• Contraindicated in patients with a previous history of cholestatic jaundice/hepatic dysfunction associated with Ampicillin/Sulbactam.
• Should not be used in patients with a history of severe diarrhea or colitis associated with antibiotic use.
• Not recommended for individuals with a history of seizures or other neurological disorders.
• Avoid if you have severe kidney disease or kidney failure.
• Do not use if you are currently taking certain medications that may interact with Ampicillin/Sulbactam, such as other antibiotics or anticoagulants.
• Contraindicated in patients with mononucleosis or lymphatic leukemia.

The side effects of Ampicillin 500mg, Sulbactam 250MG Injection may include:

• Diarrhea
• Nausea and vomiting
• Skin rash or itching
• Allergic reactions (hives, itching, difficulty breathing)
• Vaginal itching or discharge
• Joint pain or swelling
• Fever
• Easy bruising or bleeding

Following are the precautions and warnings for Ampicillin 500mg, Sulbactam 250mg Injection:

• This medication should not be used in patients with a known allergy to penicillin or any other beta-lactam antibiotics.
• It is crucial to complete the full course of treatment as prescribed, even if symptoms improve, to prevent the development of antibiotic-resistant bacteria.
• Patients with a history of severe allergies or asthma should be closely monitored as severe allergic reactions can occur.
• Ampicillin and Sulbactam may cause diarrhea, and if it becomes severe or persistent, it may indicate a new infection. Contact your doctor immediately.
• This medication should be used with caution in patients with kidney or liver disease, as dosage adjustments may be necessary.
• Elderly patients may be more susceptible to the side effects of this medication, particularly diarrhea and skin reactions.
• Before using this medication, inform your doctor about any other medications you are taking, including over-the-counter drugs, to avoid potential drug interactions.
• Pregnant and breastfeeding women should only use this medication if clearly needed and under the supervision of a healthcare professional.

Following are the drug interactions for Ampicillin 500mg, Sulbactam 250MG Injection:

• Concomitant use with other antibiotics like Chloramphenicol or Macrolides may reduce the effectiveness of Ampicillin.
• Probenecid can increase the blood levels of Ampicillin, potentially enhancing its effects and side effects.
• The injection may decrease the effectiveness of oral contraceptives, requiring additional contraceptive measures.
• Sulbactam may reduce the efficacy of Methotrexate, a medication used in cancer treatment.
• It can prolong the effects of muscle relaxants like Succinylcholine, requiring dosage adjustments.
• The injection may increase the risk of bleeding when used with anticoagulants or antiplatelet drugs.
• Allopurinol, a medication for gout, may increase the risk of allergic reactions when used with Ampicillin.

Following are the food interactions for Ampicillin 500mg, Sulbactam 250mg Injection:

• Avoid consuming alcohol during the treatment course as it may increase the risk of side effects and affect the effectiveness of the medication.
• Grapefruit and grapefruit juice should be consumed with caution as they may interfere with the absorption of Ampicillin, leading to reduced drug levels in the blood.
• Dairy products like milk, yogurt, and cheese can potentially decrease the absorption of Ampicillin. Consider taking the medication 2-3 hours before or after consuming dairy.
• Avoid high-fiber foods immediately after taking the medication as fiber may bind with the antibiotic, reducing its effectiveness.
• Maintain a balanced diet to support overall health and recovery during the treatment period.
• Ensure adequate fluid intake to prevent dehydration, especially if diarrhea occurs as a side effect.
• Avoid consuming any food or beverage that causes an allergic reaction, as the medication may increase the sensitivity to certain allergens.
• Consult your healthcare provider for specific dietary recommendations based on your medical condition and individual needs.

Ampicillin 500mg, Sulbactam 250MG Injection should be stored in a controlled environment, preferably in a cool and dry place, away from direct sunlight and moisture. The original packaging should be kept intact, ensuring the medication remains sealed and protected from external contaminants. It is crucial to maintain the integrity of the injection by avoiding exposure to extreme temperatures, such as those near heating appliances or in hot environments. Always check the expiration date, and dispose of any unused or expired injections promptly. Proper disposal methods should be followed, avoiding disposal in sinks, toilets, or drains. Consult your pharmacist or healthcare professional for guidance on safe disposal practices to minimize environmental impact. Keep the medication out of children's reach to prevent accidental exposure.

Following are the quick tips for Ampicillin 500mg, Sulbactam 250MG Injection:

• Ensure the injection is administered by a trained healthcare professional.
• Verify the medicine's expiry date before use.
• Inform your doctor if you have allergies or are taking other medications.
• Report any side effects or unusual symptoms to your doctor immediately.
• Avoid missing doses; complete the full course as prescribed.
• Do not reuse or share needles; dispose of them safely.
• Store the injection as directed, usually at room temperature, away from light.
• Always follow your healthcare provider's instructions for proper use.