Unifyline (100mg/5ml) 60ml Syrup

Doxofylline is a medication used to treat chronic respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). It functions as a bronchodilator, relaxing the muscles lining the airways, thereby promoting easier breathing. Doxofylline inhibits cyclic nucleotide phosphodiesterases (PDEs), which are enzymes that break down cyclic AMP (cAMP) and cyclic GMP (cGMP) in the cells. By stopping the breakdown of these molecules, doxofylline increases their levels, leading to increased activation of certain protein kinase enzymes, such as PKA and PKC. These protein kinases activate various cellular responses, including the relaxation of airway smooth muscle and inhibition of inflammatory cytokines, providing an anti-inflammatory effect that helps manage inflammation associated with asthma and COPD. Additionally, doxofylline may also inhibit the release of histamine from mast cells, further contributing to its bronchodilating effects. Overall, doxofylline relaxes the bronchial smooth muscle, increases airflow, and reduces airway inflammation, thereby improving respiratory function in individuals with lung diseases. However, it is important to note that drugs in the theophylline class, including doxofylline, have a narrow therapeutic index, meaning they require careful monitoring of blood levels to ensure both effectiveness and to avoid adverse effects.

Xanthine

Unveiling its multifaceted uses and transformative applications as follows:

• Doxofylline is used to treat respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma and is helpful in relaxing the airways and improving breathing.
• It is often used with other medications such as bronchodilators or anti-inflammatory drugs.
• Doxofylline also serves as adjunctive therapy for partial obstruction of the upper respiratory tract due to allergic conditions, chronic bronchitis, and sinusitis.
• This medication helps loosen mucus, making the cough more effective, which aids in expelling mucus and phlegm from the lungs.
• It's important to note that doxofylline is not curative and only relieves the symptoms of respiratory distress.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• For bronchial asthma- Adults and children above 12 years of age- 5-10 mg/kg/day in 2-4 divided doses per day.
• For bronchial asthma- Children 2 to 12 years of age- 5-7 mg/kg/day in 2 divided doses per day.
• For bronchial asthma- Children 1 to 2 years of age- 5 mg/kg/day in 2 divided doses per day.
• For bronchial asthma- Children 6 months to 1 year of age- 4 mg/kg/day in 2 divided doses per day.
• For bronchial asthma- Children 3 months to 6 months of age- 3 mg/kg/day in 2 divided doses per day.
• For chronic pulmonary obstruction- 2 sprays (1% solution) in each nostril every 6 hours.
• For emphysema- Initially, 100-200 mg 2 times a day. The dose should be increased gradually up to 600 mg 2 times a day.
• For acute exacerbation of chronic bronchitis- Initially, 100-200 mg 2 times a day. The dose should be increased gradually up to 600 mg 2 times a day.
• For rhinitis- 1 spray in each nostril 3 times per day.
• For chronic sinusitis- 1 spray in each nostril 3 times per day. This can be safely used for 2-3 months.

An overdose of Doxofylline may lead to a stimulated nervous system and increased excitability. To help control this, healthcare providers may administer sedatives, such as benzodiazepines, to reduce agitation and encourage relaxation. They may also use antihistamines such as diphenhydramine to alleviate any stimulant effects and manage allergic reactions that may occur. It is vital to seek immediate medical attention if an overdose is suspected to prevent complications and ensure appropriate treatment.

If you have missed a dose of Doxofylline, it is important to take it as soon as possible. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose and resume your regular dosing schedule. This is to ensure that you don't take too much of the medication, as taking an extra dose can lead to an overdose or unpleasant side effects. If you are unsure about what to do after missing a dose, it is always best to contact your doctor or pharmacist for advice. They may provide guidance specific to your situation and help you navigate the next steps safely. It's important to remember that the dose and frequency of use depend on your specific medical condition and age, so it's essential to follow the instructions provided by your doctor or pharmacist. If you have any further questions or if you experience additional slip-ups in your dosing schedule, give their office a call for advice on what to do.

Before you use Doxophylline 100mg/5ml, make sure to read the medication guide provided by your pharmacist. Every time you get a refill, ensure you read the guide again. If you have queries, you can always reach out to your doctor or pharmacist. This medication is for oral use. You can take it every 6 hours, but ensure to drink plenty of water or other fluids to prevent dehydration. The dosage is based on your medical condition, age, and response to treatment. You should not take this medication more often than recommended or for longer. If your condition does not improve or you notice the symptoms are getting worse, reach out to your doctor. Ensure you inform your doctor or pharmacist of your allergies before you use this product as it may contain inactive ingredients which can cause allergic reactions. If you are pregnant or planning to be, ensure you discuss the risks and benefits of using the medication with your doctor. The same applies to breastfeeding mothers as it is not known if the medication passes into breast milk. Avoid alcohol as it may increase the risk of central nervous system side effects. This medication may cause nausea, but if the symptoms persist or worsen, let your doctor or pharmacist know. It is advisable to seek immediate medical attention if you notice serious breathing problems as it occurs more commonly in patients with underlying heart and breathing problems.

Discerning instances where this medication may not be appropriate:

• Experienced severe allergic reactions to it or its ingredients in the past, resulting in anaphylaxis.
• Asthma and allergies to other xanthine derivative medicines like aminophylline and theophylline.
• Recently suffered a heart attack or has a history of specific heart problems. Abnormal heart rhythms can be caused by the drug, so it's vital to be monitored by a doctor when taking it.
• A history of seizures or epilepsy, as Doxofylline may cause seizures in some.
• Liver or kidney disease. The drug is eliminated from the body by the kidneys and may build up to harmful levels in people with impaired kidney function. Side effects may also be experienced by those with liver disease.
• Pregnant or planning to become pregnant. Doxofylline is a category C drug, meaning it should only be used if the potential benefit justifies the potential risk to the baby.
• Breastfeeding. It is unknown if doxofylline passes into breast milk. Talk to your doctor before using this medication while breastfeeding.
• Share your medical history and all current medications with your doctor before taking Doxofylline.

Unraveling the side effects lurking behind this medications are as follows:

• Nausea
• Vomiting
• Diarrhea
• Constipation
• Headache
• Increased heart rate • Irregular heart rhythm
• Flushed skin
• Muscle twitches
• Seizures
• High blood pressure
• Anxiety
• Insomnia
• Irritability
• Mood swings
• Impaired judgment
• Paranoia
• Aggression
• Hyperactivity
• Dyskinesia
• Tremors
• Vision changes
• Loss of balance
• Coordination problems

The warnings and precautions associated with Doxofylline are:

• Patient with CV disease (e.g. cardiac arrhythmias, angina pectoris, chronic right ventricular failure, CHF, hypertension), COPD.
• Active or history of peptic ulcer and/or GERD.
• Hyperthyroidism, hypoxaemia, concomitant infection, inflammation, history of seizure disorder.
• Smokers (including after cessation of smoking).
• Hepatic and renal impairment.
• Children and elderly.
• Pregnancy.

The drug interactions with doxofylline include:

• Other Xanthines (e.g., theophylline) – May enhance the effects and side effects of doxofylline.
• Beta-blockers (e.g., propranolol) – Can reduce the effectiveness of doxofylline and increase its side effects.

The food interactions that should be considered while using Unifyline are:

• No significant interactions with food.
• Taking with food may improve its efficacy.

Doxofylline is a synthetic bronchodilator and a xanthine derivative, prescribed for the treatment of respiratory conditions. It functions by relaxing the smooth muscle lining the airways, thereby alleviating breathing difficulties by widening the airways. In terms of storage, doxofylline 100mg/5ml should be kept in a cool, dry location, away from direct heat and light. The ideal storage temperature falls between 15-25°C (59-77°F). It is imperative to keep the medication out of the reach of children. The medication's container should be properly labeled and tightly sealed to avoid moisture exposure, which could render the medication ineffective. Use caution to store the medication in undamaged containers to maintain the safety and security of the medication. It is crucial to adhere to the storage guidelines provided by your physician or pharmacist. Improper storage can reduce the medication's effectiveness and potentially cause adverse side effects. If you have any questions or concerns regarding the appropriate storage procedures, consult a healthcare professional for clarification.

When Doxofylline is used to help manage respiratory conditions like asthma and chronic obstructive pulmonary disease (COPD), it is important to have certain lab tests to monitor the efficacy and safety of the medication. These tests serve as tools to assess how the body responds to the medication, ensuring that the prescribed dose is effective in managing symptoms and promoting normal bodily functions. One important test involves measuring a patient's lung function through various techniques, such as spirometry or peak flow measurements. These measurements are routinely taken to understand whether the medication effectively improves airflow and to determine if the dosage needs to be adjusted. Given that Doxofylline is often used to treat asthma, it is essential to monitor the level of inflammation in the airways, given the underlying inflammatory nature of the disease. Tests such as IgE levels or eosinophil counts measure the concentration of white blood cells that are involved in allergic and inflammatory responses. Additionally, given that one of the drug's potential side effects is anxiety or jittery feelings, doctors may recommend specific blood tests, such as a complete blood count or calcium level examination, to ensure normal functioning. In individuals who experience the aforementioned side effects, doctors may prescribe a test to assess the levels of neurotransmitters in the brain. To further investigate potential organ-related side effects, tests that analyze kidney and liver function via blood samples may be prescribed. These tests are important to monitor potential damage caused by the medication to these vital organs. As each patient is different, it's important to follow the advice of licensed healthcare professionals who can provide tailored advice on the lab tests needed to ensure safe and effective usage of Doxofylline.