Uperio (100mg) 28 Tablets

Sacubitril/valsartan is a combination medication that works by two distinct mechanisms. Sacubitril is a neprilysin inhibitor, which blocks the breakdown of naturally occurring peptides that regulate the neurohormonal systems, including natriuretic peptides and bradykinin. This inhibition leads to increased levels of these peptides, promoting vasodilation, natriuresis, and diuresis, resulting in reduced blood pressure and improved cardiovascular function. Valsartan, on the other hand, is an angiotensin II receptor blocker (ARB). It blocks the angiotensin II receptors, preventing the vasoconstrictive and aldosterone-secreting effects of angiotensin II. This action leads to further vasodilation, decreased blood pressure, and reduced strain on the heart, thereby complementing the effects of sacubitril and providing additional cardiovascular benefits.

Angiotensin Receptor Blocker (ARB)

Tablet

The following are the uses of Sacubitril 49mg, Valsartan 51mg Tablet:

• Used for treating heart failure and reducing the risk of hospitalization.
• Used to lower blood pressure by relaxing and widening blood vessels.
• Used to improve the heart's ability to pump blood.
• Used to enhance blood flow and oxygen delivery to vital organs.
• Used to manage symptoms like shortness of breath and fatigue.
• Used to delay the progression of heart failure and improve overall heart function.
• Used to promote long-term cardiovascular health and quality of life.

In the case of an overdose of Sacubitril 49mg and Valsartan 51mg tablets, individuals may experience symptoms such as hypotension (low blood pressure), dizziness, and fainting. The severity of these effects can vary depending on the amount ingested. It is crucial to contact a healthcare professional or a poison control center immediately for guidance on managing the overdose. They will provide specific instructions based on the individual's condition and the circumstances of the overdose.

In the case of a missed dose of Sacubitril 49mg and Valsartan 51mg Tablet, it is recommended to take the missed dose as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. It is important not to double the dose to make up for a missed one, as this may increase the risk of side effects. Consult your healthcare provider if you frequently miss doses or are unsure about how to manage missed doses.

To take the Sacubitril 49mg, Valsartan 51mg Tablet, simply swallow the tablet whole with a glass of water, preferably at the same time each day, following the exact dosage instructions provided by your healthcare professional.

Following are the conditions/situations when Sacubitril 49mg, Valsartan 51mg Tablet should not be taken:

• Should not be used in individuals with a known allergy to Sacubitril, Valsartan, or any other related ACE inhibitor or angiotensin receptor blocker (ARB) medications.
• Contraindicated in patients with a history of angioedema, either hereditary or induced by previous use of ACE inhibitors or ARBs.
• Not recommended for individuals with severe liver impairment or biliary obstruction.
• Should not be used in patients with bilateral renal artery stenosis or unilateral renal artery stenosis in a solitary kidney.
• Contraindicated during pregnancy, especially in the second and third trimesters, as it can cause fetal harm.
• Not suitable for individuals with severe hypotension (very low blood pressure).
• Should be avoided in patients with severe aortic stenosis.
• Discontinue use if significant hyperkalemia (high potassium levels) occurs during treatment.
• Not recommended for individuals with a history of or current conditions affecting the blood supply to the heart (cardiovascular disorders), including obstructive aortic valve disease, hypertrophic cardiomyopathy with outflow tract obstruction, and severe obstructive valvular disease.

The side effects of Sacubitril 49mg, Valsartan 51mg Tablet may include:

• Dizziness or lightheadedness
• Cough
• Fatigue or weakness
• Nausea and vomiting
• Diarrhea
• Low blood pressure (hypotension)
• Increased potassium levels in the blood (hyperkalemia)
• Elevated liver enzymes

Following are the precautions and warnings for Sacubitril 49mg, Valsartan 51mg Tablet:

• Patients with a known allergy to Sacubitril, Valsartan, or any other ACE inhibitors should not take this medication.
• It may cause dizziness, especially during the first few days of treatment, so caution is advised when performing tasks that require alertness.
• Regular monitoring of kidney function and blood pressure is necessary while on this medication.
• Patients with a history of angioedema should exercise caution as this medication may increase the risk of angioedema.
• This medication is not recommended during pregnancy as it may cause harm to the fetus.
• Valsartan may cause liver problems in rare cases, so liver function tests are recommended during treatment.
• Discontinuation of the medication should be gradual to avoid potential adverse effects.
• Patients with a history of severe heart failure should be closely monitored, especially at the beginning of treatment.

Following are the drug interactions for Sacubitril 49mg, Valsartan 51mg Tablet:

• Sacubitril/Valsartan can interact with non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, potentially reducing its blood pressure-lowering effect and increasing the risk of kidney problems.
• ACE inhibitors, angiotensin receptor blockers (ARBs), or aliskiren can cause increased risk of low blood pressure, high potassium levels, and impaired kidney function when used with Sacubitril/Valsartan.
• Lithium levels may be increased, raising the risk of lithium toxicity.
• When combined with diuretics, it may lead to excessive potassium loss and dehydration.
• Sacubitril/Valsartan may increase blood levels of digoxin, requiring close monitoring.
• The use of potassium-sparing diuretics or potassium supplements may lead to elevated potassium levels.
• Drugs metabolized by CYP2P4 and CYP3A4 enzymes may have altered concentrations when co-administered with Sacubitril/Valsartan.
• Sacubitril/Valsartan may increase the blood concentration of certain medications like warfarin, requiring careful monitoring.

Following are the food interactions for Sacubitril 49mg, Valsartan 51mg Tablet:

• Avoid consuming high-sodium foods like processed snacks, canned soups, and condiments, as Valsartan's effectiveness in controlling blood pressure may be reduced.
• Limit the intake of potassium-rich foods like bananas, oranges, and tomatoes, as Sacubitril can increase potassium levels in the body.
• Reduce the consumption of foods high in potassium and magnesium, as Valsartan can also increase these mineral levels.
• Avoid or limit alcohol consumption, as it can lower blood pressure further and increase the risk of dizziness and lightheadedness.
• Do not use salt substitutes or potassium supplements without medical advice, as they can alter the balance of electrolytes.
• Consuming a balanced diet with reduced sodium and controlled potassium intake is generally recommended while taking this medication.
• Grapefruit and grapefruit juice should be consumed with caution, as they may affect the metabolism of Valsartan, leading to higher blood levels and increased side effects.
• Stay hydrated by drinking enough water, especially if you experience diarrhea or vomiting.

Sacubitril 49mg, Valsartan 51mg Tablets should be stored in a cool and dry place, preferably at room temperature (around 25°C/77°F). Keep the tablets in their original container, tightly sealed, to maintain their integrity and protect them from moisture and light. It is crucial to store the medication away from heat sources like radiators or direct sunlight, as extreme temperatures can degrade the tablets. Always check the expiration date, and if the tablets are past their expiry, dispose of them properly. Do not flush or pour them into drainage systems; instead, consult your pharmacist for guidance on safe disposal methods. Keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Sacubitril 49mg, Valsartan 51mg Tablet:

• Consult your doctor before starting this medication for personalized advice.
• Ensure you understand the benefits and potential risks of this medicine.
• Take the tablet as directed by your doctor; do not crush or chew it.
• Consume the tablet with a full glass of water for easier swallowing.
• Maintain a consistent medication schedule for optimal results.
• Inform your doctor if you have a history of angioedema or kidney problems.
• Regularly monitor your blood pressure and kidney function while on this medication.
• Do not stop taking the medicine abruptly; consult your doctor for dosage adjustments.