VPN-20 (20mg) 14 Tablets

Vonoprazan is a potassium-competitive acid blocker that functions through a multi-step mechanism of action. First, it selectively inhibits the proton pump in the gastric parietal cells, which decreases gastric acid secretion. This inhibition leads to an increase in gastric pH, creating a less acidic environment in the stomach. The elevated pH enhances the effectiveness of other medications, such as antibiotics, in treating conditions like Helicobacter pylori infections. Vonoprazan is particularly useful in managing acid-related disorders, including gastroesophageal reflux disease (GERD).

Vonoprazan

Potassium Competitive Acid Blocker

Tablets

Vonoprazan is used for:

• Acid suppression
• GERD treatment
• Peptic ulcer disease
• H. pylori eradication

VPN-20 dosage for the indication of gastroesophageal reflux disease, duration as prescribed:

• Adults - 20 mg once daily.
• Children - Not recommended.

Seek immediate medical attention. Overdose may lead to severe gastrointestinal disturbances.

If you miss a dose, consume as soon as you remember. If it is close to the next feeding, skip the missed dose. Do not double up on doses.

Typically used once daily, preferably in the morning, for the treatment of acid-related disorders. Follow dosing instructions on the label.

Vonoprazan should not be used if:

• Hypersensitivity
• Severe liver impairment
• Pregnancy
• Breastfeeding
• CYP3A4 interactions (drugs metabolized by CYP3A4)

Possible side effects of Vonoprazan include:

• Nausea
• Diarrhea
• Abdominal pain
• Headache
• Dizziness

The warnings and precautions for Vonoprazan are:

• May mask symptoms of gastric malignancy
• Renal and hepatic impairment
• Pregnancy

The drug interactions with vonoprazan include:

• CYP3A4 Substrates (e.g., statins) – Can increase levels of substrates.
• Antacids – Can alter vonoprazan absorption.

The food interactions that should be considered while using vonoprazan are:

• Avoid high-fat meals, which may reduce the absorption of the product.

Vonoprazan should be stored in its original container at room temperature, away from excess moisture and heat. It is important to keep it out of reach of children and pets. If the medication is expired or no longer needed, it should be disposed of properly. Do not flush it down the toilet or pour it into a drain. Instead, follow local guidelines for medication disposal or use a drug take-back program if available to ensure safe and environmentally friendly disposal.

No

Complete the full course of therapy and strictly adhere to the doctor's recommendations.