Vaginex Vag (10%) 5g Cream

Dienestrol, the active ingredient in Dienestrol Cream, is a synthetic estrogen that exerts its effects by binding to estrogen receptors in the body. Upon binding, dienestrol mimics the actions of natural estrogen, leading to a range of physiological responses. The primary mechanism of action involves the activation of estrogen-responsive genes, which can result in cellular changes such as increased cell proliferation and differentiation in target tissues. This can lead to the development and maintenance of female secondary sexual characteristics, as well as exerting effects on various organ systems, including the reproductive, skeletal, and cardiovascular systems. Dienestrol's estrogenic activity can also influence the regulation of certain metabolic processes and contribute to the overall hormonal balance in the body.

Estrogen cream

Cream

The following are the uses of Dienestrol Cream:

• Used for treating vaginal atrophy and dryness in postmenopausal women.
• Used to alleviate discomfort and itching associated with vaginal dryness.
• Used for managing symptoms of vulvar atrophy and irritation.
• Used to improve elasticity and moisture of vaginal tissues.
• Used to reduce pain during sexual intercourse due to dryness.
• Used for long-term maintenance of vaginal health in menopause.
• Used to enhance sexual well-being and comfort in older women.
• Used as a non-hormonal alternative for vaginal dryness relief.

In the case of an overdose of Dienestrol Cream, it is important to recognize the potential severity of the situation. Overuse or ingestion of this medication can lead to an increased risk of side effects, including skin irritation, rashes, and in extreme cases, more serious health issues. If an overdose occurs, it is crucial to promptly seek medical advice. This ensures appropriate treatment and management of any adverse reactions, helping to mitigate potential health risks associated with excessive use.

In the case of a missed dose of Dienestrol Cream, it is important to apply the cream as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular application schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to get back on track with your treatment plan.

To apply Dienestrol Cream, clean and dry the affected area, then gently massage a small amount of the cream onto the skin once or twice a day, or as directed by your healthcare professional.

Following are the conditions when Dienestrol Cream should not be used:

• Must not be used in individuals with a known or suspected allergy or hypersensitivity to Dienestrol or any of the cream's components.
• Not indicated for use in children or adolescents.
• Contraindicated in pregnant women as it can cause harm to the developing fetus.
• Should not be used during breastfeeding, as it may pass into breast milk and harm the nursing infant.
• Avoid using Dienestrol Cream in patients with a history of blood clots or thrombophlebitis.
• Not recommended for individuals with a personal or family history of hormone-dependent cancers, such as breast or uterine cancer.
• Should not be applied to skin areas with open wounds, infections, or severe skin conditions.
• Contraindicated in patients with liver impairment or disease, as it may affect the metabolism of the drug.
• Not suitable for individuals with a history of stroke or cardiovascular disease.

The side effects of Dienestrol Cream may include:

• Skin irritation or redness at the application site
• Itching or rash
• Breast tenderness or swelling
• Nausea and vomiting
• Headache or dizziness
• Vaginal discharge or irritation
• Increased risk of blood clots (symptoms include leg pain, shortness of breath, chest pain)
• Allergic reactions (hives, difficulty breathing, swelling of the face/lips/tongue)

Following are the precautions and warnings for Dienestrol Cream:

• Not recommended for individuals with a known allergy or sensitivity to dienestrol or any of the cream's components.
• Avoid contact with eyes and mucous membranes, as it is intended for external use only.
• Wash your hands thoroughly after applying the cream to avoid accidental transfer to sensitive areas.
• Do not use on open wounds, cuts, or severely irritated skin.
• Patients with a history of blood clots or thrombophlebitis should use with caution and under medical supervision.
• Pregnant and breastfeeding women should consult their doctor before using this medication as it may pose risks to the fetus or infant.
• Keep out of reach of children and pets to prevent accidental ingestion or misuse.

Following are the drug interactions for Dienestrol Cream:

• It may interact with other topical medications containing estrogen or other hormones, potentially increasing the risk of systemic absorption and adverse effects.
• The use of Dienestrol Cream with systemic estrogen therapy can lead to additive effects and an increased risk of side effects related to estrogen.
• Topical corticosteroids, when used with Dienestrol Cream, might result in enhanced absorption of the cream and increased systemic estrogenic effects.
• Anticoagulants such as warfarin may have their effects altered, potentially increasing the risk of bleeding when used with this cream.
• Drugs that induce certain liver enzymes (e.g., CYP3A4 inducers) can reduce the effectiveness of Dienestrol Cream by increasing its metabolism.
• Alcohol-based products or those containing astringents might alter the skin barrier function and affect the absorption of Dienestrol Cream.
• Some medications affecting skin integrity or metabolism, such as retinoids, could potentially enhance the absorption of Dienestrol Cream.

Following are the food interactions for Dienestrol Cream:

• Dienestrol Cream should be used with caution in patients who consume large amounts of grapefruit or grapefruit juice as it may increase the risk of side effects. Grapefruit can inhibit the CYP3A4 enzyme, affecting drug metabolism.
• Alcohol consumption is not recommended during treatment with Dienestrol Cream, as it may increase the risk of certain side effects and impact the overall effectiveness of the medication.
• High-fat meals may affect the absorption of Dienestrol when taken orally, but with topical application, the interaction is minimal. However, it is best to consult your doctor for specific instructions.
• Caffeine-rich foods and beverages might interact with Dienestrol, potentially increasing side effects. It's advisable to limit caffeine intake during treatment.
• Avoid spicy foods as they may cause skin irritation or exacerbate any skin reactions associated with Dienestrol Cream application.
• Certain dairy products may contain calcium, which can interact with estrogen-like medications. Consult your doctor for guidance on dairy consumption.
• Some vegetables like broccoli and cabbage contain compounds that can affect estrogen metabolism. Consult your healthcare provider for dietary advice.
• Always follow your healthcare provider's instructions regarding dietary restrictions or modifications while using Dienestrol Cream.

Dienestrol Cream should be stored in a secure and controlled environment, preferably in a cool and dry place, maintaining a temperature between 15°C and 30°C (59°F and 86°F). Protect the cream from direct exposure to sunlight, heat, and moisture, as these conditions can degrade its quality. Always keep the cream in its original packaging, ensuring the container is tightly sealed to maintain its integrity. When disposing of expired or unused Dienestrol Cream, do not flush it down the toilet or pour it into any water source. Instead, follow local guidelines for pharmaceutical waste disposal or consult a healthcare professional for advice on safe disposal methods. Keep the cream out of the reach of children and pets to prevent accidental exposure or ingestion.

Following are the quick tips for Dienestrol Cream:

• Wash your hands before and after applying the cream to maintain hygiene.
• Apply a thin layer to the affected area as directed by your doctor.
• Gently rub the cream into the skin until it is fully absorbed.
• Avoid applying the cream to broken or irritated skin.
• Do not cover the treated area with tight-fitting clothing or bandages.
• Store the cream at room temperature, away from direct sunlight and moisture.
• Inform your doctor if you are pregnant or breastfeeding before using this medication.