VALPRO TAB 200MG

Divalproex Sodium, a medication commonly known by its brand name Depakote, exerts its therapeutic effects primarily through the metabolism of its components, valproic acid and valproate. These metabolites have multiple mechanisms of action in the central nervous system. One of the primary actions is the enhancement of gamma-aminobutyric acid (GABA) activity in the brain. GABA is an inhibitory neurotransmitter, and by increasing its effectiveness, Divalproex Sodium helps to stabilize excessive neuronal firing, thereby reducing seizures. It also blocks voltage-gated sodium channels, which play a crucial role in the generation and propagation of neuronal impulses, further contributing to its anticonvulsant effect. Moreover, Divalproex Sodium inhibits the activity of an enzyme called histone deacetylase, leading to changes in gene expression that are thought to be involved in its mood-stabilizing and anticonvulsant properties. This multifaceted mechanism of action makes Divalproex Sodium effective in managing various conditions, including epilepsy and bipolar disorder.

Divalproex Sodium 200MG

Anticonvulsant/Mood Stabilizer

Tablet

The following are the uses of Divalproex Sodium 200MG Tablet:

• Used for treating seizures and epilepsy, helping to control and reduce the frequency of seizures.
• Used for managing bipolar disorder, aiding in mood stabilization during manic or mixed episodes.
• Used to prevent migraine headaches by reducing their frequency and severity.
• Used for stabilizing mood and treating behavioral symptoms associated with various mental health conditions.
• Used to control impulsive behavior and aggression in certain behavioral disorders.
• Used for its anti-seizure properties, helping to calm excessive electrical activity in the brain.
• Used as a long-term treatment option for maintaining seizure control and mental health stability.

In the case of an overdose of Divalproex Sodium 200MG Tablets, it is important to act swiftly. Symptoms may include severe drowsiness, coordination problems, and even loss of consciousness. Promptly contact a healthcare professional or poison control center for guidance. They will provide specific instructions for managing the overdose, which may include inducing vomiting or administering activated charcoal to minimize absorption. Timely intervention is key to ensuring the best possible outcome.

In the case of a missed dose of Divalproex Sodium 200MG Tablet, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance, as they may advise you to restart the medication or adjust the dosage accordingly. It is important to maintain a consistent medication routine for optimal effectiveness.

To take Divalproex Sodium 200MG Tablet, swallow the tablet whole with a glass of water, usually two to three times a day, or as directed by your healthcare professional, ensuring you follow the prescribed dosage and schedule provided by your doctor.

Following are the conditions when Divalproex Sodium 200MG Tablet should not be used:

• Must not be taken if you have a known allergy or sensitivity to Divalproex Sodium or any of its components.
• Contraindicated in individuals with a history of liver disease, especially acute liver failure or severe liver impairment.
• Should not be used if you have a urea cycle disorder or a known mitochondrial disease.
• Avoid using Divalproex Sodium if you have a blood disorder or a known risk of bone marrow suppression.
• Do not use if you have a history of pancreatitis or if you have conditions that increase the risk of pancreatitis.
• Not suitable for individuals with a history of suicidal thoughts or behavior.
• Should not be given to individuals with a rare genetic problem of galactose intolerance, severe lactase deficiency, or glucose-galactose malabsorption.

The side effects of Divalproex Sodium 200MG Tablet may include:

• Nausea and vomiting
• Tremors or shaking
• Dizziness or drowsiness
• Weight gain
• Hair loss or thinning
• Abdominal pain or discomfort
• Vision changes (blurred or double vision)
• Skin rashes or itching

Following are the precautions and warnings for Divalproex Sodium 200MG Tablet:

• Do not start or stop this medication without consulting your doctor, as sudden changes may lead to serious side effects.
• Regular blood tests are necessary to monitor liver function, blood cell counts, and other vital parameters while on this medication.
• This medication may cause drowsiness or dizziness; avoid driving, operating machinery, or any activity that requires mental alertness until you know how it affects you.
• Inform your doctor if you have a history of liver, kidney, or pancreatic disorders, as this medication may need to be adjusted or monitored more closely.
• Do not consume alcohol while taking Divalproex Sodium, as it can increase the risk of liver damage and other side effects.
• Pregnant women, or those planning to become pregnant, should consult their doctor before taking this medication, as it may cause harm to the fetus.
• Breastfeeding women should also seek medical advice as Divalproex Sodium can pass into breast milk and may harm nursing infants.
• Keep this medication out of the reach of children and pets, and store it in a safe and secure place.

Following are the drug interactions for Divalproex Sodium 200MG Tablet:

• It may interact with other central nervous system (CNS) depressants like benzodiazepines, barbiturates, or alcohol, leading to increased sedation and respiratory depression.
• Carbamazepine and other enzyme-inducing antiepileptic drugs can decrease Divalproex levels, reducing its effectiveness.
• Divalproex can increase the effects of other antiepileptic drugs, such as phenytoin and lamotrigine, requiring dose adjustments.
• The effectiveness of oral contraceptives may be reduced, requiring alternative contraceptive methods.
• Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the risk of bleeding when taken with Divalproex.
• Divalproex can decrease the clearance of selective serotonin reuptake inhibitors (SSRIs), increasing their blood levels and potential side effects.
• Propofol and other anesthetic agents may require dosage adjustments when used with Divalproex due to altered metabolism.

Following are the food interactions for Divalproex Sodium 200MG Tablet:

• Avoid excessive alcohol consumption while taking this medication as it can increase the risk of liver damage and enhance the sedative effects of the drug.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of Divalproex Sodium, leading to increased drug levels in the body.
• High-fat meals may slightly delay the absorption of Divalproex Sodium, but it generally does not affect the overall effectiveness of the medication.
• Carbohydrate-rich meals can increase the absorption of Divalproex Sodium, potentially leading to higher drug concentrations in the body.
• Foods containing high levels of protein may reduce the absorption of Divalproex Sodium, resulting in lower drug levels in the bloodstream.
• It is advisable to maintain a consistent diet and not make significant dietary changes while taking Divalproex Sodium to ensure stable drug levels.
• Always follow the dietary recommendations provided by your healthcare professional when using Divalproex Sodium.

Divalproex Sodium 200MG Tablets should be stored in a cool and dry place, preferably at room temperature, away from direct exposure to sunlight, heat, and moisture. The original packaging should be kept intact and tightly sealed to maintain the integrity of the medication. It is crucial not to store the tablets in the bathroom or kitchen, as these areas may have high humidity levels that can impact the medicine's effectiveness. Always check the expiration date, and dispose of any unused or expired tablets responsibly. Do not flush them or throw them into the trash; instead, follow local guidelines for pharmaceutical waste disposal or consult your pharmacist for appropriate methods to ensure environmental safety. Keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Divalproex Sodium 200MG Tablet:

• Take the tablet as directed by your doctor, typically 2-3 times a day.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• You can take it with or without food, but be consistent.
• Maintain a consistent schedule to ensure stable blood levels.
• If you experience drowsiness, avoid driving or operating machinery.
• Inform your doctor about all medications you are taking.
• Store the medication at room temperature, away from moisture and heat.