Valporx (500mg) 30 Tablets

Divalproex Sodium, a medication commonly used to treat epilepsy and bipolar disorder, works primarily by increasing the levels of gamma-aminobutyric acid (GABA) in the brain. GABA is an inhibitory neurotransmitter, and enhancing its activity helps to calm excessive neuronal firing. This medication achieves this effect by inhibiting the breakdown of GABA through the blockade of GABA transaminase, an enzyme responsible for degrading GABA. Additionally, Divalproex Sodium promotes the release of GABA from presynaptic neurons, further increasing its availability in the brain. The overall effect is a stabilization of neuronal activity, leading to a reduction in seizures and mood stabilization.

Divalproex Sodium 500mg

Anticonvulsant/Mood Stabilizer

Tablet

The following are the uses of Divalproex Sodium 500mg Tablet:

• Used for treating seizures and epilepsy to control and reduce the frequency of seizures.
• Used for stabilizing mood in individuals with bipolar disorder, helping to manage manic or mixed episodes.
• Used for preventing migraine headaches by reducing their frequency and severity.
• Used for treating acute mania, providing rapid relief from manic symptoms.
• Used for managing behavioral issues and aggression in certain conditions, such as impulse control disorders.
• Used for supporting the treatment of various psychiatric disorders as an adjunctive therapy.
• Used for promoting overall neurological balance and regulating brain activity.

Follow these dosage instructions:

• Take as per doctor's Prescription.
• Take one tablet per day as prescribed by the doctor, through mouth with a glass of water.
• Take the tablet at a scheduled day regularly to get the most benefit.
• Your doctor will determine the treatment length based on your symptom severity.

In the case of an overdose of Divalproex Sodium 500mg Tablets, the severity of symptoms can vary depending on the amount ingested. Common signs include nausea, vomiting, drowsiness, and coordination difficulties. More serious cases may lead to respiratory depression, coma, or even death. Prompt medical intervention is vital, as treatment may involve gastric lavage, administration of activated charcoal, and supportive care to manage symptoms and prevent potential complications.

In the case of a missed dose of Divalproex Sodium 500mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance, as they may need to adjust your dosage or provide specific instructions to ensure the medication's effectiveness.

To take Divalproex Sodium 500mg Tablet, swallow the tablet whole with a full glass of water, usually 2 to 3 times a day, or as directed by your healthcare professional, ensuring you follow the prescribed dosage and schedule provided by your doctor.

Following are the conditions or situations when Divalproex Sodium 500mg Tablet should not be used:

• Do not take if you have a known allergy to Divalproex Sodium or related medications.
• Avoid if you have liver disease or significant liver dysfunction.
• Should not be used if you have a urea cycle disorder.
• Contraindicated in individuals with known mitochondrial disorders.
• Not suitable for patients with known pancreatitis.
• Do not use if you have a rare genetic disorder called Alpers-Huttenlocher syndrome.

The side effects of Divalproex Sodium 500mg Tablet may include:

• Nausea and vomiting
• Tremors or shaking
• Weight gain or loss
• Hair loss or thinning
• Fatigue and drowsiness
• Stomach pain or digestive issues
• Memory problems or confusion
• Skin rashes or itching

Following are the precautions and warnings for Divalproex Sodium 500mg Tablet:

• This medication should not be taken if you are allergic to divalproex sodium or any of its ingredients.
• It requires careful monitoring of liver function, especially during the first six months of treatment, as it can cause severe liver damage. Regular blood tests are necessary.
• Divalproex Sodium may cause pancreatitis, a serious inflammation of the pancreas. Seek immediate medical attention if you experience severe abdominal pain, nausea, and vomiting.
• Patients with a history of liver, kidney, or pancreatic disorders should use this medication with caution and under close medical supervision.
• This drug may increase the risk of suicidal thoughts or actions. Monitor for any changes in mood or behavior, and seek medical advice if any concerns arise.
• It can cause platelet dysfunction, which may lead to abnormal bleeding. Patients should be monitored for any signs of unusual bleeding or bruising.
• Divalproex Sodium can cause drowsiness and dizziness. Avoid driving or operating heavy machinery until you know how the medication affects you.
• Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as this medication may cause harm to the fetus or infant.

Following are the drug interactions for Divalproex Sodium 500mg Tablet:

• Carbapenem antibiotics like meropenem or ertapenem may decrease the effectiveness of Divalproex, potentially leading to breakthrough seizures.
• Divalproex can increase the concentration of certain antidepressants like fluoxetine, paroxetine, and venlafaxine, requiring dosage adjustments.
• When combined with lamotrigine, Divalproex may increase lamotrigine's metabolism, leading to decreased efficacy of lamotrigine.
• The effectiveness of estrogen-containing oral contraceptives may be reduced by Divalproex, requiring an alternative or additional contraceptive method.
• Divalproex can increase the blood levels of certain benzodiazepines, such as clonazepam and lorazepam, potentially requiring dosage adjustments.
• Drugs that induce hepatic enzymes, like carbamazepine, can decrease Divalproex levels, necessitating increased monitoring and potential dosage adjustments.
• Propofol and Divalproex may have additive CNS depressant effects, requiring close monitoring during concurrent use.

Following are the food interactions for Divalproex Sodium 500mg Tablet:

• Avoid excessive alcohol consumption while taking this medication as it can increase the risk of liver problems and enhance the sedative effects of the drug.
• Grapefruit and grapefruit juice should be consumed with caution as they can alter the blood levels of Divalproex Sodium, potentially affecting its effectiveness.
• High-fat meals may slightly increase the absorption of the drug, but this is generally not a significant concern.
• Avoid consuming large amounts of foods rich in tyramine (aged cheeses, cured meats, certain types of beer) as Divalproex Sodium may interact with tyramine, leading to high blood pressure.
• Caffeine-rich foods and beverages may slightly reduce the absorption of Divalproex Sodium, but this interaction is usually not clinically significant.
• There is no need to take the medication with food, but if stomach upset occurs, taking it with meals can help alleviate this side effect.
• Maintain a consistent diet and avoid drastic changes in eating habits while on Divalproex Sodium to ensure stable medication levels in the body.
• Always consult your healthcare provider or pharmacist for personalized advice on food interactions based on your specific health condition.

Divalproex Sodium 500mg Tablets should be stored in a secure and dry location, away from direct sunlight and moisture. Maintain the tablets in their original container, tightly sealed, to ensure their integrity and prevent exposure to environmental factors. It is crucial to avoid storing them in bathrooms or near heat-emitting appliances, as temperature fluctuations can impact their effectiveness. Regularly check the expiration date, and for proper disposal, consult a pharmacist or healthcare professional to ensure safe and environmentally friendly practices. Keep the medication out of children's reach to prevent accidental consumption, and always exercise caution when handling and storing Divalproex Sodium Tablets.

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Following are the quick tips for Divalproex Sodium 500mg Tablet:

• Swallow the tablet whole; do not crush, chew, or break it.
• Take the tablet with or without food as directed by your doctor.
• Maintain a consistent daily routine for taking the medication.
• If you experience side effects like nausea, try taking the tablet with food.
• Avoid missing doses; take it as soon as you remember if you miss one.
• Inform your doctor about all medications you are taking to prevent interactions.
• Regular blood tests may be required to monitor sodium levels.
• Consult your doctor if you have any concerns or experience severe side effects.