Valron (75mg) 3ml, 100 Ampoule Injections

Diclofenac Sodium 75mg Injection is a nonsteroidal anti-inflammatory drug (NSAID) used to manage pain and inflammation in various conditions. It is commonly administered intramuscularly for the relief of acute musculoskeletal pain, post-operative pain, or pain associated with conditions such as osteoarthritis and rheumatoid arthritis. Diclofenac works by inhibiting the production of prostaglandins, substances that mediate pain and inflammation in the body. This injection provides rapid relief, making it suitable for acute conditions where oral administration is not feasible. It should only be used under medical supervision due to the potential for side effects, such as gastrointestinal issues, cardiovascular risks, or renal complications.

Diclofenac Sodium 75mg

NSAID

injection

Following are the uses of Diclofenac Sodium 75mg Injection:

• Used to provide quick relief from moderate to severe pain and inflammation associated with conditions such as arthritis, spondylitis, or musculoskeletal injuries.
• Effective in managing acute episodes of pain related to post-operative or post-traumatic conditions.
• Helps reduce pain and swelling in conditions involving soft tissue injuries or ligament strains.
• Commonly used to treat pain associated with renal colic or gallbladder conditions.
• Provides symptomatic relief in cases of severe menstrual cramps (dysmenorrhea).
• Often administered as a short-term treatment option for acute gouty arthritis to manage pain and inflammation.
• Used to relieve pain and discomfort in individuals undergoing certain surgical procedures.
• May be recommended as part of a comprehensive pain management plan for specific medical conditions requiring rapid intervention.

Dosage of Diclofenac Sodium 75mg Injection:

• For adults, the typical dose is 75 mg administered as a deep intramuscular injection into the gluteal muscle, once or twice daily, depending on the severity of the condition and as directed by a healthcare provider.
• For acute pain relief, a single 75 mg dose may be sufficient; however, in severe cases, a second dose may be administered after at least 6 hours, ensuring the total daily dose does not exceed 150 mg.
• In cases of renal colic, an additional dose may be given after 30 minutes if necessary.
• The injection is intended for short-term use, typically for no more than 2–3 days, after which treatment may continue with oral or rectal forms if required.

In case of an overdose of Diclofenac Sodium 75mg Injection, immediate medical attention is crucial. Overdose symptoms may include severe stomach pain, nausea, vomiting, drowsiness, dizziness, gastrointestinal bleeding, difficulty breathing, or loss of consciousness. If you suspect an overdose, contact emergency medical services or your nearest healthcare provider promptly. Treatment for overdose typically involves supportive measures, such as monitoring vital signs, managing symptoms, and preventing complications. Activated charcoal may be administered to reduce absorption if the overdose is recent. Severe cases may require hospitalization, intravenous fluids, and interventions to protect the stomach lining or manage kidney or liver damage. Always inform your healthcare provider about the overdose details, including the amount administered and the timing, to ensure appropriate care.

Diclofenac Sodium 75mg Injection is typically administered in a clinical setting by a healthcare professional. If a dose is missed, it is generally managed during the next scheduled visit or as advised by the healthcare provider. Since this medication is often used for acute pain or inflammation, maintaining the schedule is essential for effective relief. If you are self-administering under medical guidance and miss a dose, consult your healthcare provider promptly for instructions. Do not double the dose to compensate for the missed one, as this can increase the risk of side effects.

To use Diclofenac Sodium 75mg Injection typically, this injection is administered by a healthcare professional either intramuscularly or intravenously, depending on your condition. The frequency and dosage will be determined based on the specific needs of your treatment plan. It’s important not to self-administer this injection unless specifically instructed by your healthcare provider.

When not to use Diclofenac Sodium 75mg Injection:

• If you are allergic to diclofenac, other NSAIDs, or any of the ingredients in the formulation.
• In individuals with a history of gastrointestinal disorders, such as ulcers, gastrointestinal bleeding, or inflammatory bowel disease, as diclofenac can worsen these conditions.
• Avoid use in patients with severe liver or kidney impairment, as diclofenac may further damage these organs.
• Do not use in individuals with a history of heart disease, high blood pressure, or stroke, as diclofenac may increase the risk of cardiovascular events.
• If you are pregnant, especially in the third trimester, or breastfeeding, as diclofenac may harm the fetus or infant.
• Avoid using diclofenac in combination with other NSAIDs, as this can increase the risk of side effects such as gastrointestinal bleeding or kidney damage.
• Do not use in children under 18 years old, unless directed by a healthcare provider.

Side effects of Diclofenac Sodium 75mg Injection may include:

• Nausea
• Vomiting
• Dizziness
• Headache
• Rash
• Edema
• Abdominal pain
• Diarrhea
• Constipation
• Fatigue

Precautions and Warnings for Diclofenac Sodium 75mg Injection include:

• Use with caution in individuals with a history of gastrointestinal disorders, such as ulcers or bleeding, as diclofenac may worsen these conditions.
• Do not exceed the recommended dose, as higher doses can increase the risk of gastrointestinal bleeding, kidney damage, and cardiovascular complications.
• Use diclofenac cautiously in individuals with liver or kidney issues, as it can worsen these conditions or cause further organ damage.
• Diclofenac should be avoided during pregnancy, especially in the third trimester, as it may harm the fetus. Consult your healthcare provider if you are pregnant or breastfeeding.
• Use with caution in individuals with heart disease, high blood pressure, or a history of stroke, as diclofenac may increase the risk of cardiovascular events.
• If you experience any signs of an allergic reaction, such as rash, swelling, or difficulty breathing, discontinue use immediately and seek medical attention.
• Alcohol should be avoided while taking diclofenac, as it can increase the risk of side effects such as dizziness, stomach ulcers, or gastrointestinal discomfort.
• Regular monitoring of kidney and liver function is recommended during long-term use, especially for those with pre-existing conditions.
• Diclofenac can cause fluid retention and may not be suitable for individuals with heart or kidney conditions requiring fluid management.
• Keep diclofenac out of reach of children to prevent accidental overdose.

Drug Interactions for Diclofenac Sodium 75mg Injection include:

• Diclofenac may interact with anticoagulants like warfarin, increasing the risk of bleeding due to its effect on blood clotting.
• Concurrent use of diclofenac with other NSAIDs, such as ibuprofen or aspirin, can increase the risk of gastrointestinal ulcers, bleeding, and kidney damage.
• Combining diclofenac with blood pressure medications, like ACE inhibitors, diuretics, or angiotensin II receptor blockers, may impair kidney function and reduce their effectiveness.
• Diclofenac may increase the blood levels of lithium, which could lead to lithium toxicity.
• Use of diclofenac with corticosteroids can enhance the risk of gastrointestinal side effects, such as ulcers or bleeding.
• Diclofenac may interact with methotrexate, increasing the risk of toxicity, particularly in high doses.
• If you are taking diuretics (water pills), diclofenac may reduce their effectiveness and worsen kidney function.
• Combining diclofenac with cyclosporine or tacrolimus may increase the risk of kidney damage.
• Antidepressants, especially SSRIs or SNRIs, may increase the risk of bleeding when used with diclofenac.

Food Interactions for Diclofenac Sodium 75mg Injection include:

• Diclofenac can be taken with or without food, but taking it with food may help reduce gastrointestinal discomfort or irritation.
• Avoid consuming alcohol while using diclofenac, as it can increase the risk of stomach bleeding and other gastrointestinal side effects.
• High-fat meals may delay the absorption of diclofenac, potentially affecting its effectiveness, though the impact is usually minimal.
• It is advisable to limit the intake of caffeinated beverages like coffee or tea, as they can increase the risk of stomach irritation when combined with diclofenac.
• Taking diclofenac with citrus fruits or juices, particularly grapefruit, may interfere with its absorption and effectiveness.

Diclofenac Sodium 75mg Injection should be stored in a cool, dry place away from direct sunlight and moisture. It is important to keep the medication at room temperature, ideally between 15°C to 30°C (59°F to 86°F). Avoid storing the injection in the bathroom or near a heat source. Keep it out of reach of children to prevent accidental ingestion. If you have any unused or expired diclofenac injections, do not dispose of them in the trash or down the drain. Instead, follow your healthcare provider's guidance or local disposal regulations for proper disposal. Always ensure that the packaging remains intact and avoid using the injection if it appears damaged or expired.

Quick Tips for Diclofenac Sodium 75mg Injection:

• Always use the lowest effective dose for the shortest duration to minimize the risk of side effects.
• Administer the injection as directed by your healthcare provider; do not self-administer unless trained to do so.
• Avoid mixing diclofenac with other NSAIDs (e.g., ibuprofen, aspirin) to reduce the risk of gastrointestinal bleeding.
• Regularly monitor kidney function and liver health if using diclofenac for extended periods.
• Take with food to reduce the risk of stomach irritation or upset.
• Stay hydrated while using diclofenac to support kidney function.
• Limit alcohol consumption to prevent increased risk of side effects like stomach ulcers or bleeding.
• If you experience symptoms like stomach pain, black stools, or vomiting, contact your healthcare provider immediately.