VARIVAC 0.5ML INJ

The Varicella Vaccine Injection works by stimulating the body's immune system to produce a protective response against the varicella-zoster virus, which causes chickenpox. It contains a weakened (attenuated) live strain of the virus. When the vaccine is administered, the attenuated virus infects cells in the body, triggering an immune response without causing the actual disease. The immune system recognizes the viral antigens and generates a response by producing antibodies and activating T-cells. This immune response helps the body build a memory of the virus, so that when exposed to the actual wild-type varicella virus, the immune system can quickly recognize and neutralize it, preventing or reducing the severity of chickenpox. The vaccine's mechanism of action relies on this mimicry of natural infection, allowing the body to develop immunity without the risks associated with the actual disease.

Varicella Vaccine is a live-attenuated virus vaccine.

Injection

The following are the uses of Varicella Vaccine Injection:

• Used for preventing chickenpox (varicella), a highly contagious viral infection with symptoms like itchy rash and fever.
• Used for reducing the severity of chickenpox.
• Used for immunization against varicella-zoster virus, providing long-term protection.
• Used for individuals without a known history of chickenpox, to protect against potential complications.
• Used for post-exposure prophylaxis, especially in high-risk settings like healthcare facilities.
• Used for outbreak control, helping to limit the spread of chickenpox in communities.
• Used for individuals with weakened immune systems, to prevent severe complications.

In the case of an overdose of Varicella Vaccine Injection, it is important to recognize that this is an uncommon occurrence. The vaccine is typically administered in a controlled setting, making overdoses rare. However, if an overdose is suspected, symptoms may include mild fever, redness, or swelling at the injection site. It is advisable to contact a healthcare professional for guidance and monitoring, as they can provide appropriate advice based on individual circumstances.

In the case of a missed dose of Varicella Vaccine Injection, it is important to consult your healthcare provider or immunisation clinic promptly. They will advise you on the appropriate course of action, which may involve administering the missed dose as soon as possible or adjusting the vaccination schedule. Do not delay seeking advice, as timely vaccination is crucial for building immunity against the varicella virus. Your healthcare provider will guide you on how to proceed and ensure you stay on track with the recommended vaccination timeline.

To administer the Varicella Vaccine, gently clean the injection site with an alcohol wipe, insert the needle at a 90-degree angle, and slowly inject the vaccine into the muscle, ensuring the entire dose is delivered before withdrawing the needle.

Following are the conditions/situations when Varicella Vaccine Injection should not be administered:

• Do not administer to individuals who have a history of severe allergic reactions to the vaccine, gelatin, neomycin, or any other component of the vaccine.
• Contraindicated in individuals who are immunocompromised or have a weakened immune system due to diseases or medications.
• Avoid using in people with a family or personal history of immune system disorders or immune deficiencies.
• Do not give to pregnant women or those planning to become pregnant shortly after vaccination.
• Not recommended for individuals with a moderate or severe illness, including fever, until they have recovered.
• Should not be used in individuals with a history of blood disorders or bleeding problems.
• Contraindicated in individuals with a history of seizures or neurological disorders.
• Do not administer to individuals with a history of severe reactions to neomycin or other antibiotics in the same class.
• Not suitable for people who have recently received blood transfusions or other blood products.
• Avoid using in individuals with a history of brain or central nervous system disorders.

The side effects of Varicella Vaccine Injection may include:

• Pain, redness, swelling, or itching at the injection site
• Mild rash or bumps on the skin
• Fever
• Headache
• Fatigue and general feeling of discomfort
• Loss of appetite
• Nausea
• Joint or muscle pain

Following are the precautions and warnings for Varicella Vaccine Injection:

• Not recommended for individuals with a history of severe allergic reactions to gelatin, neomycin, or any other component of the vaccine.
• Should not be administered to pregnant women; women should avoid pregnancy for at least 1 month after vaccination.
• Individuals with a weakened immune system, including those with HIV/AIDS, cancer, or undergoing immunosuppressive therapy, should consult a healthcare provider before vaccination.
• Caution is advised for individuals with a history of blood disorders or easy bruising, as they may be at risk of bleeding or bruising at the injection site.
• Individuals with a moderate or severe acute illness should postpone vaccination until recovery.
• Varicella vaccine should not be given to individuals with a history of tuberculosis or active, untreated tuberculosis.
• Healthcare providers should be informed about any recent blood transfusions or other vaccines received before administering the varicella vaccine.

Following are the drug interactions for Varicella Vaccine Injection:

• Varicella vaccine should not be administered with other live vaccines like MMR or measles vaccine due to potential interference.
• Avoid using with immunosuppressive agents as these drugs may reduce vaccine efficacy.
• The effectiveness of the vaccine may be decreased when used with corticosteroids or other immunosuppressive therapies.
• Concurrent use with immune globulins may interfere with the desired immune response.
• Antineoplastic agents can reduce the response to the vaccine, so a minimum interval should be maintained between them.
• Aspirin or aspirin-containing products should be avoided for 6 weeks after vaccination due to the risk of Reye's syndrome.
• The vaccine may interact with other live attenuated viral vaccines, potentially reducing their effectiveness.

Following are the food interactions to be aware of with Varicella Vaccine Injection:

• Avoid consuming alcohol before and after vaccination as it may reduce the effectiveness of the vaccine and impact your immune response.
• There is no specific dietary restriction associated with the Varicella Vaccine, but maintaining a healthy diet with a balanced intake of nutrients can support your immune system.
• Stay hydrated by drinking plenty of fluids, especially water, to ensure your body is prepared for the immune response post-vaccination.
• Avoid consuming excessive amounts of sugar or highly processed foods, as these can potentially weaken the immune system's response.
• Consume foods rich in Vitamin C, such as citrus fruits, bell peppers, and broccoli, as they can support immune function.
• Include foods with Vitamin E, like nuts, seeds, and spinach, which have antioxidant properties that can aid in the immune process.
• Consider adding probiotics, found in yogurt and fermented foods, to your diet to promote a healthy gut microbiome, which is closely linked to immune health.

The proper storage and disposal of Varicella Vaccine Injection is crucial for maintaining its efficacy and safety. It should be stored in a refrigerator at a temperature between 2°C and 8°C (35°F and 46°F), ensuring it remains protected from light and moisture. Avoid freezing the vaccine as it can damage its potency. Always check the expiration date before use, and do not use the vaccine if it has expired. For disposal, do not throw away the vaccine in regular household trash or flush it down the toilet. Contact your healthcare provider or local waste management authorities for guidance on proper disposal methods to ensure environmental safety. Keep the vaccine out of children's reach to prevent accidental exposure.

Following are the quick tips for Varicella Vaccine Injection:

• Get the injection as directed by your doctor, usually a single dose.
• Inform your doctor if you have any allergies or medical conditions before vaccination.
• The vaccine is typically given in the upper arm or thigh.
• It is important to complete the full course of vaccination for optimal protection.
• Report any side effects like fever, rash, or injection site pain to your healthcare provider.
• Avoid sharing personal items with someone who has chickenpox after vaccination.
• Store the vaccine as directed and handle with care to maintain its effectiveness.