Vastor-AM (10/10mg) 10 Tablets

Amlodipine 10mg and Atorvastatin 10mg have distinct mechanisms of action. Amlodipine, a calcium channel blocker, inhibits the influx of calcium ions into smooth muscle cells, primarily in the peripheral arterial resistance vessels. This inhibition leads to vasodilation, reducing peripheral vascular resistance and lowering blood pressure. The reduced vascular resistance also decreases the workload on the heart, further contributing to blood pressure control. Atorvastatin, on the other hand, is a potent HMG-CoA reductase inhibitor. It works by competitively inhibiting HMG-CoA reductase, a rate-limiting enzyme in cholesterol biosynthesis. This inhibition decreases intracellular cholesterol levels, stimulating the production of hepatic LDL receptors, which enhances LDL uptake and lowers LDL cholesterol levels in the blood. This mechanism plays a crucial role in managing dyslipidemia and reducing cardiovascular risk.

Amlodipine 10mg, Atorvastatin 10mg

Calcium channel blocker, HMG-CoA reductase inhibitor.

Tablet

The following are the uses of Amlodipine 10mg, Atorvastatin 10mg Tablet:

• Used for lowering high blood pressure and preventing angina (chest pain).
• Used to treat hypertension, allowing better blood flow and reducing the heart's workload.
• Used to lower high cholesterol levels and prevent cardiovascular issues.
• Used to reduce the risk of heart attacks, strokes, and other heart-related problems.
• Used for long-term management of high blood pressure and high cholesterol.
• Used to improve overall heart health and reduce the risk of cardiovascular events.
• Used to manage symptoms of atherosclerosis and improve blood circulation.

In the case of an overdose of Amlodipine 10mg or Atorvastatin 10mg tablets, individuals may experience symptoms such as dizziness, lightheadedness, and a rapid or pounding heartbeat. It is important to seek medical advice promptly. Other potential effects include excessive lowering of blood pressure, leading to fainting or weakness, and in some cases, an overdose may cause liver damage or muscle pain. Quick action and professional medical guidance are essential to mitigate potential health risks.

In the case of a missed dose of Amlodipine 10mg, it is generally recommended to take the missed dose as soon as you remember, but if it's almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. For Atorvastatin 10mg Tablet, if you miss a dose, take it as soon as you remember, however, if it's close to your next dose, skip the missed dose and continue with your regular dosing routine. It's important to consult your healthcare provider if you frequently miss doses or have concerns about managing your medication schedule.

To take Amlodipine 10mg and Atorvastatin 10mg tablets, swallow one tablet of each medication daily, preferably at the same time each day, with or without food, as directed by your healthcare provider.

Following are the conditions/situations when Amlodipine 10mg and Atorvastatin 10mg Tablet should not be used:

• Should not be used in patients with a known allergy to Amlodipine, Atorvastatin, or any other calcium channel blockers or statins.
• Contraindicated in patients with severe liver disease.
• Should not be used in individuals with uncontrolled or severe heart failure.
• Not recommended for patients with a history of stroke or transient ischemic attack (TIA).
• Should not be used if you have a history of rhabdomyolysis (a serious muscle condition).
• Contraindicated in patients with uncontrolled hypothyroidism.
• Not suitable for individuals with severe hypotension (very low blood pressure).
• Should be avoided if you have a history of angioedema (swelling of deep skin layers) with other calcium channel blockers.

The side effects of Amlodipine 10mg, Atorvastatin 10mg Tablet may include:

• Dizziness or lightheadedness
• Headache
• Fatigue or weakness
• Swelling of ankles or feet (peripheral edema)
• Flushing (feeling of warmth or redness in the face)
• Constipation or diarrhea
• Muscle pain or weakness
• Joint pain

Following are the precautions and warnings for Amlodipine 10mg, Atorvastatin 10mg Tablet:

• Individuals with a known allergy to amlodipine, atorvastatin, or any other ingredients in the tablet should not take this medication.
• Patients with liver problems should use this medication with caution, as it can affect liver function and regular monitoring may be necessary.
• This medication may cause muscle pain or weakness; if you experience these symptoms, seek medical attention immediately.
• Amlodipine may cause dizziness or lightheadedness, especially when standing up; caution should be exercised to avoid falls.
• Patients with a history of heart disease or diabetes should be monitored closely while taking this medication.
• Avoid grapefruit or grapefruit juice as it can increase the levels of atorvastatin in the blood, leading to potential side effects.
• Inform your doctor if you are taking other medications, as Amlodipine and Atorvastatin can interact with various drugs.
• Do not stop taking this medication suddenly without consulting your doctor, as it may lead to adverse effects.

Following are the drug interactions for Amlodipine 10mg and Atorvastatin 10mg Tablet:

• Grapefruit juice can increase the blood levels of amlodipine, potentially leading to increased side effects. Avoid excessive consumption.
• Amlodipine may enhance the blood pressure-lowering effects of antihypertensive drugs, requiring close monitoring.
• Atorvastatin can increase the effects of anticoagulants like warfarin, necessitating regular blood tests to adjust dosage.
• When combined with certain antifungal medications (e.g., ketoconazole), the risk of muscle-related side effects may increase.
• Taking amlodipine with other blood pressure medications, such as beta-blockers, may cause excessive blood pressure drop.
• Atorvastatin's blood levels can be increased by some antibiotics (e.g., erythromycin), raising the risk of muscle issues.
• The risk of muscle problems is higher when combining atorvastatin with other cholesterol-lowering drugs like gemfibrozil.
• Certain HIV protease inhibitors may increase atorvastatin levels, requiring dosage adjustments.

Following are the food interactions for Amlodipine 10mg and Atorvastatin 10mg Tablet:

• Grapefruit and grapefruit juice should be avoided as they can interfere with the metabolism of Amlodipine, leading to increased drug levels and potential side effects like low blood pressure and irregular heart rate.
• Avoid excessive alcohol consumption as it can increase the blood pressure-lowering effect of Amlodipine, and when combined with Atorvastatin, it may increase the risk of liver problems.
• Atorvastatin's absorption can be reduced by consuming large amounts of fiber-rich foods like whole grains, legumes, and certain fruits and vegetables, so it's best to maintain a consistent diet.
• Fatty and high-fat foods may increase the absorption of Atorvastatin, potentially leading to higher drug levels in the body.
• Dairy products, particularly those high in calcium, can interact with Atorvastatin, reducing its absorption. It is advisable to separate Atorvastatin doses from calcium-rich foods by at least 2 hours.
• Avoid consuming large amounts of licorice as it can decrease the effectiveness of Amlodipine by reducing its absorption.
• Herbal supplements like St. John's Wort may decrease the levels of Atorvastatin, potentially reducing its effectiveness.
• Always consult your healthcare provider for personalized advice on managing food interactions with these medications.

Amlodipine 10mg and Atorvastatin 10mg tablets should be stored in a cool, dry place, preferably at room temperature, ensuring protection from light and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. Avoid exposing the medication to high temperatures or storing it in bathrooms or near heat sources, as this can impact its effectiveness. Always adhere to the expiration date on the packaging, and when disposing of unused or expired tablets, do not flush them or pour them down the drain. Instead, consult a pharmacist or healthcare professional for appropriate disposal guidelines. It is crucial to keep these medications out of children's reach to prevent accidental consumption.

Following are the quick tips for Amlodipine 10mg and Atorvastatin 10mg Tablet:

• Always take the medication as directed by your doctor; do not adjust the dosage without medical advice.
• Take Amlodipine 10mg with or without food, preferably at the same time each day.
• Atorvastatin 10mg Tablet is best taken in the evening, and can be taken with or without food.
• Do not crush or chew the tablets; swallow them whole with a full glass of water.
• Avoid grapefruit and grapefruit juice as they may interact with these medications.
• Inform your doctor about all the medicines you are currently taking to prevent potential drug interactions.
• Store the medications at room temperature, away from moisture and heat.