VEGANET 0.3% E/DROPS

Netilmicin is an aminoglycoside antibiotic that exerts its bactericidal effect by primarily targeting bacterial protein synthesis. It binds to specific receptors on the bacterial ribosome, particularly the 30S subunit, leading to misreading of the genetic code during translation. This binding interferes with the proper alignment of aminoacyl-tRNA at the ribosomal A-site, resulting in the incorporation of incorrect amino acids into the growing polypeptide chain. Consequently, Netilmicin disrupts the synthesis of essential bacterial proteins, leading to the production of faulty proteins and ultimately causing bacterial cell death. The primary mechanism of action is through the inhibition of protein synthesis, making it particularly effective against a range of Gram-negative bacteria, including Pseudomonas aeruginosa.

Aminoglycoside antibiotic

Drop

The following are the uses of Netilmicin Drop:

• Used for treating serious bacterial infections, particularly those affecting the lungs, urinary tract, and skin.
• Used for its effectiveness against a range of bacteria, including some resistant strains.
• Used for its ability to penetrate well into respiratory secretions, making it suitable for treating lung infections.
• Used as an alternative for patients allergic to other antibiotics in the aminoglycoside family.
• Used for its concentration in the kidneys, making it useful for treating urinary tract infections.
• Used to prevent infection during high-risk surgeries or procedures.
• Used for its efficiency in severe infections when other antibiotics may not be sufficient.
• Used under strict medical supervision due to potential side effects on the kidneys and hearing.

In the case of an overdose of Netilmicin Drops, it is important to act promptly. If you suspect an overdose, contact your healthcare provider or seek medical assistance immediately. They will be able to provide guidance and support to manage the situation effectively. Common symptoms of an overdose may include difficulty breathing, severe dizziness, and hearing loss. Quick action can help mitigate potential risks and ensure the best possible outcome.

In the case of a missed dose of Netilmicin Drops, it is important to administer the medication as soon as you remember. However, if it is almost time for the next scheduled dose, it is best to skip the missed dose and continue with the regular dosing schedule. Avoid doubling the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, it is recommended to set reminders or use a medication organizer to help you stay on track with your treatment plan. Consult your healthcare provider if you have any concerns or questions regarding missed doses.

To use Netilmicin Drops, gently squeeze the prescribed number of drops into the affected ear, ensuring the dropper does not touch the ear to avoid contamination, and follow the dosage instructions provided by your healthcare professional.

Following are the conditions when Netilmicin Drops should not be used:

• Not recommended for individuals with a known allergy to Netilmicin or other aminoglycoside antibiotics.
• Contraindicated in patients with a history of hypersensitivity or severe reactions to similar medications.
• Should not be used in patients with myasthenia gravis as it can worsen muscle weakness.
• Not suitable for individuals with kidney disease or reduced kidney function.
• Avoid using in patients with hearing loss or conditions affecting the auditory nerve.
• Contraindicated in patients with conditions that affect neuromuscular transmission.
• Should not be administered to newborns, especially premature babies, due to the risk of kidney damage.

The side effects of Netilmicin Drop may include:

• Ear pain or discomfort
• Dizziness or vertigo
• Nausea and vomiting
• Hearing loss or ringing in the ears (tinnitus)
• Skin rash or itching
• Kidney problems (decreased kidney function)
• Nerve damage (neurotoxicity)
• Allergic reactions (skin rash, itching, swelling, difficulty breathing)

Following are the precautions and warnings for Netilmicin Drop:

• Avoid using Netilmicin Drop if you have a known allergy or hypersensitivity to netilmicin or other aminoglycoside antibiotics. Cross-sensitivity may occur.
• Prolonged use of Netilmicin Drop may lead to overgrowth of non-susceptible organisms, including fungi. Discontinue use if superinfection occurs.
• Caution in patients with kidney impairment; dosage adjustments may be necessary. Regular monitoring of kidney function is advised.
• Netilmicin Drop should be used with extreme caution in patients with myasthenia gravis as it may worsen muscle weakness.
• May cause ototoxicity and nephrotoxicity, especially in patients with pre-existing kidney or hearing disorders. Regular monitoring is essential.
• Avoid using other ototoxic medications concurrently to minimize the risk of hearing impairment.
• Elderly patients may be more susceptible to the drug's side effects; use with caution and monitor closely.

Following are the drug interactions for Netilmicin Drop:

• Aminoglycosides, including Netilmicin, can potentiate the effects of neuromuscular blocking agents, leading to prolonged paralysis.
• Concomitant use with other nephrotoxic drugs, such as cisplatin or amphotericin B, may increase the risk of kidney damage.
• Netilmicin may enhance the ototoxic effects of loop diuretics like furosemide, increasing the risk of hearing impairment.
• When combined with other ototoxic medications, such as vancomycin or platinum-based chemotherapy, it can increase the risk of hearing loss.
• The use of Netilmicin with other antibiotics like polymyxins or certain cephalosporins may result in additive nephrotoxicity.
• Caution is advised when administering Netilmycin with drugs that affect renal function, as it may alter Netilmicin's elimination and increase toxicity.
• The concurrent use of Netilmicin with muscle relaxants during anesthesia can prolong neuromuscular blockade, requiring close monitoring.

Following are the food interactions to consider with Netilmicin Drops:

• Avoid consuming alcohol during the treatment period as it can increase the risk of side effects and may cause dizziness or drowsiness.
• Grapefruit and grapefruit juice should be consumed with caution as they can increase the levels of Netilmicin in the blood, potentially leading to higher side effects.
• Avoid high-sodium foods as Netilmicin can increase sodium levels in the body, and excessive sodium intake may worsen health conditions like hypertension.
• Limit the consumption of foods rich in potassium, such as bananas and oranges, as Netilmicin can affect potassium levels, and an imbalance may occur.
• Avoid eating or drinking anything that has been contaminated with bacteria, as Netilmicin is an antibiotic and may not be effective against foodborne illnesses.
• There is no specific food requirement for Netilmicin, but maintaining a balanced diet is recommended to support overall health during treatment.
• Always follow the dosage instructions provided by your healthcare professional, and inform them about any dietary concerns or restrictions you may have.
• Ensure you complete the full course of treatment to prevent antibiotic resistance.

Netilmicin Drops should be stored with care to ensure their effectiveness and safety. Keep the bottle in a cool, dry place, preferably at room temperature, away from direct exposure to sunlight or excessive heat. Protect the drops from freezing temperatures as well. Ensure the bottle is tightly sealed after each use to maintain sterility and prevent contamination. Do not use the drops if the solution appears discoloured or contains particles. It is crucial to dispose of any unused or expired medication properly, avoiding pouring it down the drain or flushing it. Consult your pharmacist for guidance on safe disposal methods to protect the environment and prevent accidental exposure. Keep the medication out of children's reach to prevent accidental ingestion.

Following are the quick tips for Netilmicin Drops:

• Administer the prescribed dosage of drops as directed by your healthcare professional.
• Ensure the dropper is clean and sterilized before each use.
• Hold the dropper close to the eye without touching it, and gently squeeze the required number of drops.
• Close your eye for a few seconds after administering the drops to allow absorption.
• Avoid touching the dropper tip to your eye or any surface to prevent contamination.
• If using other eye medications, wait at least 5 minutes before applying the next medication.
• Store the drops in a cool, dry place, away from direct sunlight and heat.