Vendep (37.5mg) 20 Tablets

Venlafaxine 37.5mg tablets primarily act by inhibiting the reuptake of serotonin, norepinephrine, and dopamine in the brain. This mechanism of action is achieved through its ability to block the transporters responsible for the reuptake of these neurotransmitters, leading to increased levels in the synaptic cleft. By enhancing the availability of serotonin and norepinephrine, venlafaxine helps to regulate mood, emotions, and pain perception, making it effective in the treatment of major depressive disorder and certain types of anxiety disorders. The modulation of these neurotransmitters is believed to contribute to the therapeutic effects observed with this medication.

Serotonin-norepinephrine reuptake inhibitor (SNRI)

Tablet

The following are the uses of Venlafaxine 37.5mg Tablet:

• Used for treating major depressive disorder, helping to alleviate symptoms like persistent sadness and loss of interest.
• Used for managing anxiety disorders, including generalized anxiety disorder, to reduce excessive worry and tension.
• Used to treat panic disorder, assisting in controlling panic attacks and reducing associated fear.
• Used in the management of social anxiety disorder, helping individuals cope with social situations.
• Used for certain types of chronic pain management, as it can modulate pain perception.
• Used as part of a comprehensive treatment plan to improve overall mood and daily functioning.
• Used to enhance emotional well-being and cognitive function in specific patient populations.

Follow these dosage instructions for adult patients:

• Adults Dosage for Depression

Initial dose

• Adults Dosage for Generalized Anxiety Disorder

Initial dose

• Adults Dosage for Social Anxiety Disorder

Extended-release

• Adults Dosage for Panic Disorder

Initial dose

In the case of an overdose of Venlafaxine 37.5mg Tablets, individuals may experience a range of symptoms including nausea, vomiting, dizziness, and in severe cases, seizures or loss of consciousness. Prompt medical intervention is necessary to manage the overdose effectively. Medical professionals may induce vomiting or administer activated charcoal to prevent further absorption of the medication. Close monitoring of vital signs and supportive care are crucial during the treatment process.

In the case of a missed dose of Venlafaxine 37.5mg Tablet, it is generally recommended to take the missed dose as soon as you remember, provided it is not too close to the time of your next scheduled dose. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. However, if you miss multiple doses, consult your healthcare provider for guidance, as they may advise you to adjust the timing or dosage to ensure the medication's effectiveness. Do not double the dose to make up for a missed one, as this may increase the risk of side effects.

To take Venlafaxine 37.5mg Tablet, swallow the tablet whole with a full glass of water, preferably in the morning or as directed by your healthcare professional, without crushing or chewing it.

Following are the conditions/situations when Venlafaxine 37.5mg Tablet should not be taken:

• Avoid use in individuals with a known allergy to Venlafaxine or similar antidepressants.
• Do not use if you have taken Monoamine Oxidase Inhibitors (MAOIs) within the last 14 days.
• Contraindicated in patients with uncontrolled narrow-angle glaucoma.
• Should not be used in individuals with severe hypertension (high blood pressure).
• Not recommended for patients with a history of seizures or epilepsy.
• Avoid use in individuals with a history of bleeding disorders or recent significant bleeding.
• Do not use in patients with a history of heart disease or recent heart attack.
• Contraindicated during the acute recovery period after a heart attack.
• Should be avoided in individuals with kidney disease or impairment.

The side effects of Venlafaxine 37.5mg Tablet may include:

• Nausea and vomiting
• Dry mouth
• Dizziness or lightheadedness
• Headache
• Insomnia or sleep disturbances
• Increased sweating
• Constipation
• Sexual dysfunction

Following are the precautions and warnings:

• Venlafaxine 37.5mg Tablet should not be started or stopped abruptly without medical supervision. Gradual adjustment of dosage as directed by a healthcare professional is essential.
• Patients with a history of suicidal thoughts or behavior, or those exhibiting signs of depression, should be closely monitored, especially at the beginning of treatment or when adjusting the dosage.
• This medication may increase the risk of bleeding. Patients with a history of bleeding disorders or those taking blood thinners should exercise caution and inform their doctor.
• Individuals with hypertension should have their blood pressure monitored regularly as Venlafaxine can elevate blood pressure.
• Venlafaxine can cause an increase in cholesterol levels. Regular monitoring of cholesterol is recommended during treatment.
• Caution is advised for patients with a history of seizures or those taking medications that lower the seizure threshold.
• It may cause an increase in heart rate and blood pressure, so individuals with cardiovascular disease or hypertension should be closely monitored.
• Pregnant or breastfeeding women should consult their doctor before taking Venlafaxine, as it may have potential risks for the fetus or infant.

Following are the drug interactions for Venlafaxine 37.5mg Tablet:

• Avoid use with monoamine oxidase inhibitors (MAOIs), as this combination can lead to serious adverse reactions, including serotonin syndrome.
• Concomitant use with other central nervous system (CNS) active drugs (e.g., benzodiazepines, opioids, antipsychotics) may increase the risk of sedation, respiratory depression, and cognitive impairment.
• Venlafaxine can increase plasma concentrations of lithium, potentially leading to lithium toxicity. Monitor lithium levels.
• May increase bleeding risk when taken with anticoagulants (e.g., warfarin), antiplatelet drugs, or nonsteroidal anti-inflammatory drugs (NSAIDs).
• Venlafaxine may enhance the effects of antihypertensive medications, potentially causing excessive hypotension.
• Use with caution alongside triptans due to the risk of serotonin syndrome.
• Can increase plasma concentrations of diazepam and other drugs metabolized by CYP2D6, possibly requiring dosage adjustments.
• Certain anticonvulsants (e.g., phenytoin, carbamazepine) may decrease venlafaxine levels, potentially reducing its effectiveness.

Following are the food interactions for Venlafaxine 37.5mg Tablet:

• Grapefruit and grapefruit juice should be consumed with caution as they may affect the metabolism of Venlafaxine, potentially increasing its blood levels and the risk of side effects.
• Alcohol may increase the risk of side effects like dizziness and sleepiness, so it's best to avoid or limit alcohol consumption.
• Fatty meals may slightly increase the absorption of Venlafaxine, but this effect is not clinically significant.
• Caffeine intake should be monitored as it can increase anxiety and restlessness, especially during the initial phase of treatment.
• No specific dietary restrictions are necessary, but maintaining a balanced diet is advisable for overall well-being.
• Always take the medication as directed by your healthcare professional, regardless of meal timing.
• Venlafaxine can be taken with or without food, but consistency in timing relative to meals is recommended.
• If you have any concerns about food interactions, consult your healthcare provider for personalized advice.

Venlafaxine 37.5mg Tablets should be stored in a secure and dry location, away from moisture and direct sunlight. Maintain a consistent room temperature for storage, avoiding extreme heat or cold. It is crucial to keep the tablets in their original packaging, ensuring the container is tightly sealed to prevent contamination. Check the expiration date regularly and dispose of any unused or expired medication promptly. When disposing of Venlafaxine tablets, do not flush them down the toilet or sink. Instead, consult your pharmacist or local waste management guidelines for appropriate disposal methods to protect the environment. Keep the medication out of children's reach, ensuring it is stored in a safe and inaccessible place to prevent accidental consumption.

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Following are the quick tips for Venlafaxine 37.5mg Tablet:

• Start with the lowest effective dose and gradually increase as directed by your doctor.
• Take the tablet at the same time each day to maintain consistent levels.
• Swallow the tablet whole with a full glass of water; do not crush, chew, or break it.
• Venlafaxine may be taken with or without food, but taking it with food may reduce nausea.
• Avoid alcohol consumption as it can intensify side effects.
• Do not abruptly stop taking the medication; follow your doctor's instructions for tapering.
• Store the medication at room temperature, away from light and moisture.