VENU TAB 20MG

Vonoprazan 20mg Tablet acts by inhibiting the potassium-competitive acid blockers (P-CABs) in the stomach. It specifically targets the potassium-binding site of the gastric H+/K+-ATPase, also known as the proton pump, which is responsible for the final step of gastric acid secretion. By binding to this site, vonoprazan blocks the transport of protons into the stomach, effectively reducing gastric acid secretion. This mechanism of action is distinct from proton pump inhibitors (PPIs) as it provides rapid and potent acid inhibition without the need for acid activation, offering a more consistent and sustained suppression of gastric acid production.

Potassium-competitive acid blocker.

Tablet

The following are the uses of Vonoprazan 20mg Tablet:

• Used for treating gastroesophageal reflux disease (GERD) by reducing stomach acid production.
• Used for managing gastric ulcers, aiding in healing and preventing recurrence.
• Used for eradicating Helicobacter pylori (H. pylori) infections in combination with antibiotics.
• Used for treating Zollinger-Ellison syndrome, a rare condition causing excessive acid production.
• Used for relieving heartburn, acid regurgitation, and other acid-related symptoms.
• Used for maintaining remission in patients with erosive esophagitis.
• Used for improving acid-related discomfort and promoting gastrointestinal healing.

In the case of an overdose of Vonoprazan 20mg Tablets, individuals may experience intensified side effects, including severe stomach pain, nausea, and potential gastrointestinal bleeding. Promptly contact a healthcare professional or poison control center for guidance and treatment options. They will likely recommend immediate medical attention, where the patient may receive supportive care and monitoring to manage symptoms and prevent further complications. Quick action is essential to ensure the best possible outcome.

In the case of a missed dose of Vonoprazan 20mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you frequently miss doses, it is recommended to set reminders or use a pill organizer to help you stay on track with your medication routine. It is also advisable to inform your healthcare provider if you miss multiple doses, as they may provide specific instructions for your situation.

To take Vonoprazan 20mg Tablet, swallow the tablet whole with a glass of water, preferably in the morning before meals, following the dosage instructions provided by your healthcare professional.

Following are the conditions or circumstances when Vonoprazan 20mg Tablet should not be taken:

• Avoid use if you have a known allergy to Vonoprazan or any other proton pump inhibitors (PPIs).
• Do not take this medication if you have severe liver impairment or severe kidney disease.
• Contraindicated in patients with low magnesium levels or those who are at risk of low magnesium levels.
• Not recommended for long-term use without medical supervision, as it may increase the risk of certain infections and fractures.
• Should not be used if you have a stomach or intestinal ulcer caused by a certain bacterial infection (Helicobacter pylori) without also taking antibiotics.
• Avoid use if you have had a recent gastrointestinal (GI) surgery, as it may interfere with healing.
• Do not take this medication if you are currently taking certain drugs that may interact with Vonoprazan, such as warfarin, methotrexate, or atazanavir.

The side effects of Vonoprazan 20mg Tablet may include:

• Diarrhea
• Headache
• Dizziness
• Abdominal pain
• Nausea
• Fatigue
• Allergic reactions (such as rash, itching, or swelling)
• Altered liver function (rare)

Following are the precautions and warnings for Vonoprazan 20mg Tablet:

• Do not use in patients with known hypersensitivity or allergy to Vonoprazan or any of its excipients.
• Caution in patients with liver impairment as dosage adjustments may be necessary.
• Long-term use may lead to vitamin B12 deficiency, so monitoring is recommended.
• Patients should be advised to report any signs of infection, as the medication may mask symptoms.
• This medication may interact with other drugs, so patients should inform their doctor about all medications they are taking.
• Not recommended for use in pregnant or breastfeeding women unless the potential benefits outweigh the risks.
• Patients should be encouraged to maintain a healthy lifestyle and diet, as the medication does not replace the need for lifestyle modifications.

Following are the drug interactions for Vonoprazan 20mg Tablet:

• Co-administration with Clopidogrel may reduce the antiplatelet effect of Clopidogrel, potentially affecting its effectiveness.
• Vonoprazan can increase plasma concentrations of Warfarin, potentially enhancing its anticoagulant effect and increasing the risk of bleeding.
• It may decrease the absorption of Ketoconazole and other antifungal drugs, reducing their effectiveness.
• Concomitant use with Atazanavir or other protease inhibitors may decrease their plasma concentrations, potentially reducing their therapeutic effect.
• Drugs metabolized by CYP3A4 enzymes, such as Cyclosporine, may have reduced blood levels when taken with Vonoprazan.
• The effectiveness of Methotrexate may be reduced due to decreased absorption when used with Vonoprazan.
• Rifampicin can decrease the plasma concentrations of Vonoprazan, potentially reducing its therapeutic effect.

Following are the food interactions for Vonoprazan 20mg Tablet:

• Avoid consuming grapefruit or grapefruit juice as it may interfere with the breakdown of Vonoprazan, leading to increased drug levels in the body and potential side effects.
• Alcohol intake should be limited as it can increase the risk of stomach bleeding, especially when combined with Vonoprazan's stomach acid-reducing effects.
• Caffeine-containing beverages like coffee and tea might decrease the effectiveness of Vonoprazan, so consider reducing their consumption.
• Spicy foods may irritate the stomach and exacerbate acid reflux symptoms, so it's advisable to limit their intake.
• High-fat meals can delay the absorption of Vonoprazan, so it is recommended to take the medication on an empty stomach for optimal results.
• Dairy products, especially milk, can interact with Vonoprazan, potentially reducing its effectiveness. Avoid consuming large amounts of milk with the medication.
• Avoid excessive consumption of carbonated drinks as they can increase stomach pressure and potentially worsen acid reflux symptoms.
• While not a direct food interaction, smoking can reduce the effectiveness of Vonoprazan and worsen gastrointestinal issues, so it is advisable to quit smoking.

Vonoprazan 20mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. Avoid storing them in the bathroom or near heat sources like ovens or radiators, as temperature fluctuations can impact the medication's effectiveness. Always adhere to the expiration date on the packaging, and if the tablets are no longer needed or have expired, do not flush them down the toilet or drain. Consult a pharmacist or healthcare professional for guidance on safe disposal methods. It is crucial to keep medications secure and out of the reach of children to prevent accidental ingestion.

Following are the quick tips for Vonoprazan 20mg Tablet:

• Take the tablet as directed by your doctor, usually once daily.
• Swallow the tablet whole with a glass of water, preferably before a meal.
• Do not crush, chew, or break the tablet as it may affect its effectiveness.
• Maintain a consistent daily routine for taking the medication for best results.
• Inform your doctor if you have any kidney or liver problems before taking this medication.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.
• Consult your doctor if you experience any persistent or severe side effects.