Vericef Inj 1gm 1 S

Cephradine is a first-generation cephalosporin antibiotic that exerts its bactericidal effect by disrupting the synthesis of the bacterial cell wall. It specifically targets penicillin-binding proteins (PBPs), which are essential for cross-linking the peptidoglycan chains in the bacterial cell wall. By binding to these PBPs, Cephradine inhibits the final stage of peptidoglycan synthesis, leading to the weakening and eventual lysis of the bacterial cell wall. This mechanism of action is highly effective against a wide range of Gram-positive and some Gram-negative bacteria, making Cephradine a valuable treatment option for various infections.

Cephradine 1000mg

Cephalosporin antibiotic.

injection

The following are the uses of Cephradine 1000mg injection:

• Used for treating severe bacterial infections such as pneumonia, skin and soft tissue infections, and urinary tract infections.
• Used for its effectiveness against a wide range of bacteria, including Streptococcus and Staphylococcus.
• Used for rapidly controlling infections that require immediate treatment.
• Used for patients who cannot take the medication orally, ensuring they receive the necessary treatment.
• Used for preventing the spread of infection after surgery or in cases of severe trauma.
• Used for managing infections in patients with weakened immune systems, providing crucial support.
• Used for its reliability in treating community-acquired infections, offering a trusted solution.
• Used for its ability to penetrate tissues and reach infection sites, ensuring comprehensive treatment.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Acute Tonsillitis- Adults- 500 mg every six hours for seven days.
• Skin and Skin Structure Infections (Cellulitis, Etc.)- Adults- Initially, 500 mg daily followed by 250 mg daily for a maximum of 14 days.
• Severe Respiratory Tract Infections (Including Pneumonia, Etc.)- Adults- Initially, 500 mg daily followed by 250 mg daily for a maximum of 14 days.
• Intravenous Use in Bacterial infections- Adults- Intravenous- 200 mg every 12 hours for two days, followed by oral dosing for a maximum of 14 days.
• Recurrent Pylori Eradication (including Duodenal and Gastric Ulcers, Low Stomach Acid, etc.) Adults- 500 mg once daily for 10 days (may be used in combination with a proton pump inhibitor).
• Pediatric Use- Acute bacterial skin, skin structure infection- 15 mg/kg/day in divided doses every 12 hours for 14-21 days.
• Community-acquired pneumonia, including septic arthritis and osteomyelitis- 15 mg/kg/day in divided doses every 12 hours for 14-21 days.
• Urgent bacteriostasis and traitement of febrile neutropenia- 15 mg/kg/day not to exceed 750 mg/day.

In the case of an overdose of Cephradine 1000mg injection, the severity of symptoms can vary. Common signs may include nausea, vomiting, and diarrhea. More serious effects could lead to seizures, confusion, and in extreme cases, kidney damage or failure. It is crucial to promptly seek medical assistance if an overdose is suspected, as the healthcare provider will determine the best course of action, which may involve supportive measures to manage symptoms and ensure the patient's well-being.

In the case of a missed dose of Cephradine 1000mg injection, it is important to administer the missed dose as soon as possible. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication regimen. It is advisable to set reminders or use medication organizers to help you remember to take your medication on time.

To administer the Cephradine 1000mg injection, clean the injection site with an alcohol swab, insert the needle at a 90-degree angle, and slowly inject the entire contents of the vial intramuscularly or intravenously as directed by your healthcare provider, ensuring the needle is properly disposed of afterward.

Following are the conditions/situations when Cephradine 1000mg injection should not be administered:

• Should not be used in individuals with a known allergy to Cephradine or any other cephalosporin antibiotics.
• Contraindicated in patients with a history of severe allergic reactions to penicillins.
• Not recommended for patients with a history of gastrointestinal diseases, especially colitis, or those with a recent intestinal surgery.
• Should not be used in patients with severe renal impairment or kidney disease.
• Contraindicated in individuals with a history of seizures or neurological disorders.
• Not suitable for infants, especially premature babies, due to the risk of displacing bilirubin and causing brain damage.
• Should not be administered to patients with a history of sensitivity or severe reactions to lidocaine or similar local anesthetics.

The side effects of Cephradine 1000mg injection may include:

• Nausea and vomiting
• Diarrhea
• Allergic reactions, such as skin rash, itching, or hives
• Dizziness or lightheadedness
• Headache
• Vaginal itching or discharge
• Joint pain
• Fever

Following are the precautions and warnings for Cephradine 1000mg Injection:

• Not suitable for patients with a known hypersensitivity to cephradine or other cephalosporin antibiotics, as it may cause severe allergic reactions, including anaphylaxis.
• Caution is required in patients with a history of penicillin allergy due to possible cross-reactivity.
• Use with caution in patients with renal impairment, as dose adjustment may be necessary to prevent drug accumulation and toxicity.
• Prolonged use may lead to superinfection, including Clostridium difficile-associated diarrhea.
• Intravenous or intramuscular administration should be closely monitored for local site reactions, such as pain, swelling, or thrombophlebitis.
• Regular kidney and liver function tests should be performed during prolonged therapy to monitor for toxicity.
• Use with caution in elderly patients, as they may be more susceptible to renal impairment and side effects.
• Avoid mixing cephradine with other intravenous medications unless compatibility is confirmed.
• Complete the full course of treatment as prescribed to prevent bacterial resistance.

Following are the drug interactions for Cephradine 1000mg Injection:

• Cephradine may interact with other nephrotoxic drugs (e.g., aminoglycosides, diuretics like furosemide), increasing the risk of kidney damage, especially with prolonged use or high doses.
• Concurrent use with probenecid (used for gout) may increase the plasma concentration of Cephradine, leading to an increased risk of side effects.
• Cephradine may enhance the anticoagulant effect of warfarin, increasing the risk of bleeding. Regular monitoring of INR is recommended when used together.
• It may reduce the effectiveness of oral contraceptives, so additional contraception methods should be considered while using Cephradine.
• Combining Cephradine with other broad-spectrum antibiotics (e.g., chloramphenicol, tetracycline) may interfere with the antibiotic’s mechanism of action or reduce its effectiveness.
• Cephradine can interact with other medications that alter gut flora (e.g., oral antibiotics), potentially affecting its absorption and therapeutic action.
• The use of Cephradine with drugs that affect the central nervous system, such as sedatives or tranquilizers, should be monitored closely, as it may increase the risk of CNS side effects.
• Cephradine may cause a disulfiram-like reaction when combined with alcohol, leading to symptoms such as nausea, vomiting, and flushing. Avoid alcohol consumption during and for 72 hours after completing the treatment.
• Cephradine should be used cautiously with other medications that can lower blood pressure (e.g., ACE inhibitors, diuretics), as there may be an additive effect leading to hypotension.

Following are the food interactions for Cephradine 1000mg injection:

• Avoid excessive alcohol consumption during the treatment period as it may increase the risk of liver toxicity and gastrointestinal side effects.
• Grapefruit and grapefruit juice should be consumed with caution as they can inhibit the metabolism of Cephradine, potentially leading to increased drug levels in the body.
• Dairy products like milk, yogurt, and cheese should be spaced out from the time of medication intake, as calcium can bind to Cephradine and reduce its absorption.
• High-fiber foods like whole grains, legumes, and certain vegetables may interfere with the absorption of Cephradine, so it's advisable to monitor fiber intake during the treatment.
• Vitamin C-rich foods like citrus fruits, berries, and leafy greens may alter the effectiveness of Cephradine, so it's best to maintain a consistent intake of these foods during the treatment.
• Avoid spicy foods as they can potentially irritate the gastrointestinal tract, especially if you are experiencing side effects like nausea or stomach discomfort.
• Avoid caffeine-rich beverages like coffee and energy drinks, as they may exacerbate side effects such as nervousness, insomnia, and rapid heartbeat.
• Maintain a balanced diet, and ensure proper hydration during the treatment to support overall health and aid in the recovery process.

Cephradine 1000mg injection should be stored in a controlled environment, preferably in a cool and dry place at room temperature (below 25°C). Protect the injection from direct sunlight, heat, and moisture to maintain its potency. Always keep the medication in its original packaging, ensuring the container is tightly sealed to prevent contamination. It is crucial to adhere to the expiration date specified on the packaging, discarding any unused or expired injections promptly. When disposing of Cephradine, do not flush it into plumbing systems or throw it into the trash. Instead, follow local guidelines or consult healthcare professionals for appropriate disposal methods to minimize environmental impact. Keep the medication securely stored away from children to prevent accidental ingestion.

Following are the quick tips for Cephradine 1000mg injection:

• Ensure the injection is administered by a trained healthcare professional.
• Verify the medication and dosage accuracy before injection.
• Cephradine is typically given intramuscularly or intravenously as directed by the doctor.
• Inform the doctor if you have any known allergies or medical conditions.
• Store the injection at room temperature, away from direct sunlight and moisture.
• Do not use if the solution appears cloudy or contains particles.
• Dispose of used needles and syringes safely in designated containers.

When taking Cephradine 250mg, a prescription drug used to treat bacterial infections, it is necessary to undergo certain lab tests to monitor safety and progress. These typically include: