Verticil (1%) 10g Cream

Terbinafine cream, when applied topically, exerts its antifungal activity primarily by inhibiting a key enzyme called squalene epoxidase. This enzyme plays a crucial role in the biosynthesis of ergosterol, a vital component of the fungal cell membrane. By blocking the action of squalene epoxidase, terbinafine disrupts the production of ergosterol, leading to the accumulation of squalene and other sterol intermediates within the fungal cell. This disruption in sterol synthesis weakens the cell membrane integrity of susceptible fungi, ultimately resulting in fungal cell death. The selective inhibition of squalene epoxidase makes terbinafine highly effective against a range of dermatophytes and certain other fungi, while minimizing adverse effects on human cells, which do not rely on ergosterol for their membrane structure.

Antifungal

Cream

The following are the uses of Terbinafine Cream:

• Used for treating fungal skin infections such as athlete's foot, jock itch, and ringworm.
• Used for relieving itching, redness, and discomfort associated with fungal infections.
• Used for inhibiting the growth and spread of fungi on the skin's surface.
• Used for clearing up fungal infections, improving skin appearance and texture.
• Used for preventing the recurrence of fungal infections when used as directed.
• Used for treating fungal nail infections, promoting healthy nail growth.
• Used for maintaining skin and nail hygiene, reducing the risk of fungal colonization.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Athlete's foot- Apply the cream to the affected area once daily for up to 4 weeks.
• Jock itch- Apply the cream to the affected area once daily for up to 10 days.
• Ringworm- Apply the cream to the affected area once daily for up to 4 weeks.

In the case of an overdose of Terbinafine Cream, it is important to note that the cream is for topical use only, and the risk of adverse effects from excessive application is low. However, if someone has ingested a large amount of the cream, they may experience gastrointestinal symptoms such as nausea, abdominal pain, or diarrhea. In such instances, contacting a healthcare professional or poison control center is recommended for further advice and to determine the appropriate course of action.

In the case of a missed dose of Terbinafine Cream, it is important to apply the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed one and continue with your regular dosing schedule. Do not apply extra cream to make up for the missed dose, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or asking someone to remind you to help maintain consistency in your treatment plan. Consult your healthcare provider if you have any concerns or questions regarding missed doses and the proper usage of Terbinafine Cream.

To apply Terbinafine Cream, clean and dry the affected skin area, then apply a thin layer of the cream, gently rubbing it into the skin once or twice daily, or as directed by your healthcare provider, covering the entire affected area and its immediate surrounding skin.

Here are the conditions and situations when Terbinafine Cream should not be used:

• Do not use if you are allergic to terbinafine or any other antifungal medications.
• Avoid using on open wounds, burns, or severely broken skin.
• Not recommended for individuals with a history of liver or kidney disease.
• Should not be used on areas of skin affected by other skin conditions like psoriasis, eczema, or severe skin inflammation.
• Avoid using near the eyes, mouth, or other mucous membranes.
• Do not use on children without medical advice, as the safety and effectiveness in children may vary.
• Not suitable for individuals with a history of sensitivity or reactions to similar creams or their ingredients.
• Discontinue use and consult a doctor if you develop severe or persistent skin irritation, redness, or swelling at the application site.

The side effects of Terbinafine Cream may include:

• Skin irritation or redness at the application site
• Itching or burning sensation
• Dry skin
• Peeling or flaking of the skin
• Mild rash
• Allergic reactions (such as hives, swelling, or difficulty breathing)
• Increased sensitivity to sunlight
• Skin discoloration or hyperpigmentation

Following are the precautions and warnings for Terbinafine Cream:

• Avoid using the cream on open wounds, broken skin, or near the eyes, nose, or mouth.
• Wash your hands thoroughly after applying the cream to avoid accidental contact with sensitive areas.
• Discontinue use and consult a doctor if you experience severe irritation, redness, or swelling at the application site.
• Terbinafine Cream is for external use only and should not be ingested.
• Inform your healthcare provider if you have any liver or kidney problems before using this medication.
• Avoid using other topical medications or products without consulting your doctor to prevent potential interactions.
• This medication may cause an allergic reaction in some individuals; seek immediate medical attention if you experience symptoms like difficulty breathing or hives.

Following are the drug interactions for Terbinafine Cream:

• Terbinafine may interact with oral antifungal medications like itraconazole, potentially increasing the risk of liver-related side effects. Close monitoring of liver function is advised.
• Topical corticosteroids, when used with Terbinafine, may mask the symptoms of a fungal infection, allowing it to worsen.
• Using Terbinafine with other topical medications may increase skin irritation.
• Warfarin interaction is possible, as Terbinafine may affect the absorption of vitamin K, which is essential for blood clotting.
• The cream may reduce the effectiveness of live vaccines if applied to the vaccination site.
• It can also interact with drugs that prolong the QT interval, such as certain antiarrhythmic medications.
• Alcohol-based products may enhance the absorption of topical Terbinafine, potentially increasing the risk of side effects.

Following are the food interactions to be aware of when using Terbinafine Cream:

• Alcohol consumption should be limited or avoided during treatment as it can increase skin sensitivity and the risk of side effects.
• Grapefruit and grapefruit juice should be consumed cautiously as they may affect the metabolism of Terbinafine, potentially increasing its levels in the body and the risk of adverse reactions.
• Caffeine intake may need to be monitored as it can influence liver function, and Terbinafine is metabolized in the liver.
• Fatty or greasy foods are not directly contraindicated but maintaining a healthy diet is recommended to support overall skin health.
• Spicy foods should be consumed in moderation as they can cause skin flushing or irritation, especially if you have sensitive skin.
• Avoid any known food allergens, as Terbinafine may increase skin sensitivity and potentially exacerbate allergic reactions.
• There are no specific dietary restrictions with Terbinafine Cream, but staying hydrated and maintaining a balanced diet can support the overall healing process.
• Consult your healthcare provider if you have concerns about specific food interactions or if you experience any unusual symptoms while using Terbinafine Cream.

Terbinafine Cream should be stored in a cool and dry place, preferably at room temperature (around 20-25°C), away from direct sunlight and moisture. Keep the cream in its original container, tightly sealed, to maintain its integrity and prevent contamination. Avoid storing it in bathrooms or kitchens, as temperature fluctuations and humidity can impact its effectiveness. Pay attention to the expiration date on the packaging, and do not use the cream beyond this date. When disposing of any leftover or expired Terbinafine Cream, do not flush it or pour it down the drain. Instead, follow local guidelines or consult a pharmacist for safe disposal methods to minimize environmental impact. Ensure the cream is kept out of children's reach to prevent accidental exposure.

Following are the quick tips for Terbinafine Cream:

• Wash and dry the affected area before applying the cream to ensure better absorption.
• Apply a thin layer of cream to the affected skin and gently rub it in until absorbed.
• Wash your hands after applying the cream to avoid accidental contact with eyes or mouth.
• Avoid applying the cream to broken or irritated skin; if irritation occurs, stop using it.
• Do not cover the treated area with bandages or airtight dressings unless directed by a doctor.
• Continue using the cream for the full prescribed duration, even if symptoms improve.
• Store the cream at room temperature, away from direct sunlight and moisture.

Terbinafine 1%, a physician-prescribed antifungal medication, is commonly used to treat skin and nail fungal infections. This medication is generally safe and effective, but some laboratory tests may be required while taking Terbinafine 1%. These tests are precautionary and not related to the medication itself. These tests may include liver function tests to monitor liver enzyme levels, as Terbinafine is metabolized by the liver. Kidney function tests may also be ordered to assess your kidney function cautiously. Terbinafine can cause abnormalities in white blood cell counts, especially in cases of rare allergic reactions, and monitoring complete blood counts can identify changes in blood cell levels. In certain cases, your doctor may order serum concentration tests to monitor Terbinafine levels in your blood, particularly if you weigh less than 60 kg or have concurrent diseases that may affect drug absorption or metabolism. These tests are to ensure that Terbinafine 1% effectively treats your fungal infection while safeguarding your overall health. It's important to note that not all individuals taking Terbinafine 1% will require these tests. Your doctor will determine which, if any, laboratory tests you will need based on your medical condition, age, and other factors. If you have any concerns or questions regarding the tests you may need while taking Terbinafine 1%, consult your healthcare provider.