Viktana (400/100mg) 28 Tablets

Sofosbuvir and Velpatasvir are active components in the tablet you mentioned. Sofosbuvir works by inhibiting the RNA polymerase enzyme essential for viral RNA replication in the hepatitis C virus (HCV). Specifically, it targets the NS5B protein, preventing the synthesis of new viral RNA. On the other hand, Velpatasvir is a highly potent direct-acting antiviral agent that selectively inhibits the HCV NS5A protein, which is vital for viral replication and assembly. By blocking the NS5A protein, Velpatasvir disrupts multiple stages of the viral lifecycle, including replication, assembly, and release of new viral particles. This dual action of Sofosbuvir and Velpatasvir effectively suppresses HCV replication, leading to a sustained virologic response in patients undergoing treatment.

NS5A Inhibitor/Nucleotide NS5B Polymerase Inhibitor.

Tablet

The following are the uses of Sofosbuvir 400mg, Velpatasvir 100mg Tablet:

• Used for treating chronic Hepatitis C infection.
• Used for preventing liver damage and reducing the risk of liver cancer.
• Used for achieving a sustained virologic response, meaning no detectable virus in the blood.
• Used for genotype 1, 2, 3, 4, 5, or 6 chronic HCV infection.
• Used as a direct-acting antiviral medication, targeting specific viral enzymes.
• Used to achieve high cure rates, often exceeding 90%.
• Used for patients with or without cirrhosis.

In the case of an overdose of Sofosbuvir 400mg and Velpatasvir 100mg tablets, individuals may experience heightened side effects associated with the medication. These side effects can include fatigue, headache, nausea, and diarrhea. It is important to promptly contact a healthcare professional or a poison control center for guidance and monitoring. They will provide specific instructions and support to manage any potential complications arising from the overdose.

In the case of a missed dose of Sofosbuvir 400mg and Velpatasvir 100mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to get back on track with your medication regimen. It's crucial to maintain consistency with this medication for optimal treatment outcomes.

To take the Sofosbuvir 400mg and Velpatasvir 100mg Tablet, swallow one tablet whole with a glass of water, preferably at the same time each day, following the prescription instructions provided by your healthcare professional.

Following are the conditions when Sofosbuvir 400mg, Velpatasvir 100mg Tablet should not be taken:

• Should not be used in individuals with a known allergy to Sofosbuvir, Velpatasvir, or any of its excipients.
• Not recommended for patients with severe liver impairment or decompensated cirrhosis.
• Contraindicated in patients who are also taking certain medications, such as amiodarone, rifampin, carbamazepine, phenytoin, or St. John's wort, as these may reduce the effectiveness of the treatment.
• Should not be used in patients with a history of liver transplantation due to potential drug interactions.
• Not suitable for individuals with moderate or severe kidney disease without adjusting the dose or monitoring closely.

The side effects of Sofosbuvir 400mg, Velpatasvir 100mg Tablet may include:

• Fatigue
• Headache
• Nausea
• Diarrhea
• Insomnia
• Irritability
• Skin rash
• Anemia

Following are the precautions and warnings for Sofosbuvir 400mg, Velpatasvir 100mg Tablet:

• This medication is not recommended for individuals with a history of hypersensitivity or allergic reactions to Sofosbuvir or Velpatasvir or any of the tablet's components.
• Patients with severe kidney or liver disease should use this medication with caution as it may require dosage adjustments or close monitoring.
• It is important to inform your healthcare provider about all other medications you are taking, especially if you are using certain HIV or Hepatitis C medications, as drug interactions may occur.
• Regular monitoring of liver function is necessary during treatment, as it may cause liver-related side effects in some patients.
• Do not stop taking the medication without consulting your doctor, even if you feel better, to ensure the optimal effectiveness of the treatment.
• Sofosbuvir and Velpatasvir may cause fatigue and dizziness in some individuals; patients should be cautious when performing tasks that require alertness.
• Pregnant or breastfeeding women should consult their doctor before taking this medication as its effects during these periods are not well-established.
• Keep this medication out of reach of children and pets, and store it in a cool, dry place as directed.

Following are the drug interactions for Sofosbuvir 400mg, Velpatasvir 100mg Tablet:

• Co-administration with amiodarone can increase the risk of symptomatic bradycardia, requiring immediate medical attention.
• Concomitant use with rifampin may reduce the effectiveness of Sofosbuvir/Velpatasvir, as rifampin can induce the metabolism of these drugs.
• Taking with other direct-acting antiviral agents (DAAs) may require dose adjustments due to potential drug-drug interactions.
• Sofosbuvir can increase concentrations of certain HIV medications, such as atazanavir and lopinavir/ritonavir, requiring careful monitoring.
• Velpatasvir can increase the levels of statins, potentially increasing the risk of statin-related adverse effects.
• This medication may interact with certain antiarrhythmic drugs, such as flecainide and propafenone, requiring close monitoring.
• Caution is advised when using with immunosuppressants, as it may alter their effectiveness and increase the risk of opportunistic infections.

Following are the food interactions for Sofosbuvir 400mg, Velpatasvir 100mg Tablet:

• Avoid consuming grapefruit and grapefruit juice as they may affect the metabolism of the medication, potentially increasing Sofosbuvir levels in the blood.
• Alcohol intake is generally not recommended during treatment with this medication due to the potential risk of liver-related side effects.
• Fatty foods may affect the absorption of Sofosbuvir, so it is advisable to take the medication on an empty stomach, at least 1 hour before or 2 hours after a meal.
• Avoid high-fat meals as they can increase the absorption of Velpatasvir, potentially leading to increased drug levels and associated side effects.
• Dairy products like milk and yogurt may interact with Velpatasvir, so consider separating their consumption from medication timing.
• Caffeine intake should be monitored as it can affect liver enzymes, and moderation is key during treatment.
• Stay well-hydrated and maintain a balanced diet to support overall health and medication effectiveness.
• Always consult your healthcare provider for personalized advice regarding dietary restrictions and interactions.

Sofosbuvir 400mg, Velpatasvir 100mg tablets should be stored in a cool, dry place, preferably at room temperature (68°F to 77°F), away from excessive heat, moisture, or direct sunlight. It is crucial to keep the tablets in their original packaging or container, tightly sealed, to maintain their integrity and protect them from environmental factors. When disposing of unused or expired medication, do not flush or pour them down the drain; instead, follow local guidelines or consult a pharmacist for safe disposal methods. Keep the medication away from children and pets to prevent accidental ingestion, and ensure that it is stored in a secure location.

Following are the quick tips for Sofosbuvir 400mg and Velpatasvir 100mg Tablet:

• Always take the medication as directed by your doctor; do not adjust the dosage without medical advice.
• Ensure you complete the full course of treatment, even if you feel better before finishing all the tablets.
• Maintain a consistent daily routine for taking the tablets for optimal results.
• It is best to take the tablets with food to minimize stomach-related side effects.
• Avoid crushing or chewing the tablets; swallow them whole with a glass of water.
• Inform your doctor about all medications you are taking to prevent potential drug interactions.
• Store the medication in a cool, dry place, away from direct sunlight and moisture.