Vita-D3 (2000000IU) 1 Capsules

Cholecalciferol, also known as vitamin D3, has a specific mechanism of action. When administered, cholecalciferol is metabolized in the liver to form 25-hydroxycholecalciferol (calcidiol), which is further hydroxylated in the kidneys to form the active hormone 1,25-dihydroxycholecalciferol (calcitriol). Calcitriol binds to the vitamin D receptor (VDR) in various target tissues, primarily in the intestine, kidneys, and bones. This binding activates the VDR, which then forms a heterodimer with the retinoid X receptor (RXR). The VDR-RXR complex regulates gene expression by binding to specific DNA sequences, known as vitamin D response elements (VDREs), in the promoter regions of target genes. This process ultimately increases intestinal absorption of calcium and phosphorus, promotes bone mineralization, and regulates calcium and phosphate homeostasis.

Cholecalciferol 20,000,000iu

Vitamin D analogue

Capsule

The following are the uses of Cholecalciferol 20,000,000iu Capsule:

• Used for treating and preventing vitamin D deficiency, ensuring healthy bone development and preventing conditions like rickets and osteoporosis.
• Used to support calcium absorption, which is crucial for maintaining strong bones and teeth.
• Used in the management of hypoparathyroidism, a condition where the body produces too little parathyroid hormone, by aiding in calcium regulation.
• Used to enhance immune function, as vitamin D plays a role in activating immune cells and reducing the risk of autoimmune diseases.
• Used to improve muscle strength and reduce the likelihood of falls and fractures, particularly in older adults.
• Used for overall health and well-being, as vitamin D is essential for various bodily functions, including brain health and cardiovascular function.
• Used as a supplement during pregnancy and breastfeeding to ensure adequate vitamin D levels for both mother and baby.
• Used to potentially reduce the risk of certain cancers and chronic diseases, as research suggests a link between vitamin D deficiency and various health conditions.

In the case of an overdose of Cholecalciferol 20,000,000 IU capsules, symptoms may include nausea, vomiting, constipation, loss of appetite, weakness, and kidney problems. Severe cases can lead to hypercalcemia, a condition with elevated calcium levels in the blood, causing irregular heartbeat, confusion, and even coma. Prompt medical intervention is necessary, and treatment may involve hospitalization, intravenous fluids, and medications to manage calcium levels and organ function.

In the case of a missed dose of Cholecalciferol 20,000,000 IU Capsule, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, consult your healthcare provider for guidance on how to adjust your dosing schedule and ensure you receive the appropriate vitamin D supplementation.

To use Cholecalciferol 20,000,000iu Capsules, swallow the capsule whole with a glass of water, preferably with a meal or as directed by your healthcare professional, ensuring you follow the prescribed dosage instructions provided by your doctor.

Following are the conditions when Cholecalciferol 20,000,000 IU Capsule should not be used:

• Not suitable for individuals with a known hypersensitivity or allergy to Cholecalciferol or any of its excipients.
• Contraindicated in patients with elevated calcium levels in the blood (hypercalcemia) or conditions causing high calcium levels, such as primary hyperparathyroidism.
• Should not be used in patients with kidney stones or a history of kidney stones (nephrolithiasis).
• Not recommended for individuals with uncontrolled or untreated hypercalciuria (high levels of calcium in urine).
• Contraindicated in patients with a condition called hypervitaminosis D, where vitamin D levels are already excessively high.
• Should not be used in patients with conditions causing excessive calcium deposition in tissues, such as metastatic bone disease.

The side effects of Cholecalciferol 20,000,000 IU Capsule may include:

• Nausea and vomiting
• Diarrhea
• Constipation
• Loss of appetite
• Dry mouth
• Metallic taste in the mouth
• Increased thirst
• Muscle or joint pain

Following are the precautions and warnings for Cholecalciferol 20,000,000 IU Capsule:

• Do not exceed the recommended dosage, as high doses of vitamin D can lead to toxicity.
• Individuals with a history of hypercalcemia or conditions causing elevated calcium levels should use with caution and under medical supervision.
• Patients with kidney disease or impaired kidney function should exercise caution and consult a healthcare professional before use.
• Regular monitoring of calcium and phosphate levels is recommended during long-term therapy.
• Avoid taking other vitamin D supplements or calcium-containing products without medical advice to prevent excessive intake.
• Inform your doctor if you have a history of kidney stones or any other medical conditions before starting this medication.
• Cholecalciferol may interact with certain medications; inform your healthcare provider about all the medicines you are taking.
• Keep out of reach of children, as accidental overdose can be harmful.

Following are the drug interactions for Cholecalciferol 20,000,000 IU Capsule:

• Anticonvulsants like phenobarbital, phenytoin, and carbamazepine can reduce the effectiveness of Cholecalciferol by increasing its metabolism.
• Cholestyramine and colestipol may interfere with the absorption of Cholecalciferol, reducing its effectiveness.
• Thiazide diuretics, when used long-term, can cause hypercalcemia, and their concurrent use with Cholecalciferol should be monitored closely.
• Orlistat can decrease the absorption of fat-soluble vitamins, including Cholecalciferol, and may require supplementation.
• Aluminum-containing antacids may decrease the absorption of Cholecalciferol, especially with long-term use.
• Mineral oil, when used as a laxative, can interfere with the absorption of fat-soluble vitamins, including vitamin D.
• Corticosteroids (e.g., prednisone) may increase the catabolism of vitamin D and its metabolites, potentially requiring higher doses of Cholecalciferol.

Following are the food interactions for Cholecalciferol 20,000,000 IU Capsule:

• Avoid excessive consumption of foods rich in vitamin D, such as fatty fish (salmon, mackerel), egg yolks, and fortified dairy products, as it may lead to vitamin D toxicity.
• Maintain a balanced diet with adequate calcium and phosphorus, as these minerals work synergistically with vitamin D for optimal bone health.
• Consuming a high-fat meal with Cholecalciferol can enhance its absorption, as vitamin D is fat-soluble.
• Avoid excessive alcohol intake, as it may interfere with vitamin D metabolism and impair calcium absorption.
• Limit caffeine intake, as high caffeine consumption may decrease vitamin D absorption and increase its excretion.
• If you are on a low-fat diet, consult your healthcare provider, as fat is necessary for the absorption of fat-soluble vitamins like vitamin D.
• Certain medications, like orlistat and cholestyramine, can reduce the absorption of vitamin D. Consult your doctor if you are taking these medications concurrently.
• Always follow your healthcare provider's instructions regarding dietary restrictions and recommendations while taking Cholecalciferol.

Cholecalciferol 20,000,000iu Capsules should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area, away from direct sunlight, moisture, and extreme temperatures. It is crucial to keep the capsules in their original packaging or container, tightly sealed, to maintain their integrity and prevent exposure to contaminants. When disposing of unused or expired capsules, do not flush them down the toilet or discard them in regular household waste. Instead, follow local guidelines or consult your pharmacist for appropriate disposal methods to ensure environmental safety. Keep the medication out of children's reach to prevent accidental consumption, as it can be harmful if ingested inappropriately. Proper storage and disposal practices are essential to maintain the effectiveness of the medication and to prevent any potential risks associated with improper handling.

Following are the quick tips for Cholecalciferol 20,000,000iu Capsule:

• Consult a doctor before use, especially if you have a medical condition or are taking other medications.
• Take the capsule as directed by your healthcare provider, typically once a week or as advised.
• Consume the capsule with a meal to enhance vitamin D absorption.
• Ensure you maintain adequate sun exposure for natural vitamin D synthesis.
• Do not exceed the recommended dosage; high doses can lead to vitamin D toxicity.
• Store the capsules in a cool, dry place, away from direct sunlight and moisture.
• Inform your doctor if you have any kidney or liver diseases before taking this medication.
• Regularly monitor your vitamin D levels while on this medication.