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Chelidonium Majus Extract Tablet primarily exerts its effects through the presence of various alkaloids, the most prominent being chelidonine and chelerythrine. These alkaloids interact with multiple biological targets in the body. One of the key mechanisms is their ability to inhibit enzymes in the liver, such as cytochrome P450 enzymes, which are involved in drug metabolism. This inhibition can lead to increased levels of certain medications in the bloodstream, potentially enhancing their therapeutic effects or prolonging their duration of action. Additionally, Chelidonium Majus Extract Tablet may influence cell signaling pathways, particularly those related to inflammation and immune response, by modulating the activity of specific receptors and transcription factors. The alkaloids in the extract have also demonstrated choleretic effects, stimulating the production and secretion of bile, which aids in digestion and the elimination of toxins. Moreover, the extract's components can interact with the central nervous system, contributing to its traditional use in pain management and as a mild sedative.

Chelidonium Majus Extract

Antispasmodic

Tablet

The following are the uses of Chelidonium Majus Extract Tablet:

• Used for promoting bile secretion and supporting liver health
• Used for treating gallbladder disorders and easing digestion
• Used for relieving respiratory conditions like asthma and bronchitis
• Used for soothing skin irritations and minor wounds
• Used for its anti-inflammatory properties to reduce swelling
• Used for supporting the immune system and fighting infections
• Used for easing stomach aches and improving gut health
• Used for its antioxidant properties to protect cells from damage

In the case of an overdose of Chelidonium Majus Extract Tablets, it is important to seek medical advice promptly. Symptoms may include severe gastrointestinal issues such as nausea, vomiting, and diarrhea, as well as potential liver damage. Prompt action should be taken to induce vomiting or administer activated charcoal to prevent further absorption. Medical professionals can provide appropriate treatment and support to manage the overdose effectively.

In the case of a missed dose of Chelidonium Majus Extract Tablet, it is generally recommended to take the missed dose as soon as you remember, provided it is not too close to the time for your next scheduled dose. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one, as this may increase the risk of side effects. If you miss several doses, consult your healthcare professional for advice on how to safely resume your medication.

To take Chelidonium Majus Extract Tablets, swallow one tablet with a glass of water once daily, preferably at the same time each day, following the dosage instructions provided by your healthcare professional or as directed on the product packaging.

Following are the conditions or circumstances when Chelidonium Majus Extract Tablet should not be taken:

• Avoid use in individuals with a known sensitivity or allergy to Chelidonium Majus or related plants from the Papaveraceae family.
• Not suitable for children and adolescents under 18 years of age.
• Contraindicated in pregnant and breastfeeding women.
• Should not be used during lactation as it may pass into breast milk.
• Do not use if you have liver or bile duct disorders, or if you have a history of liver problems.
• Avoid if you have acute inflammatory diseases or conditions like cholecystitis, cholangitis, or hepatitis.
• Not recommended for individuals with a history of gallstones or bile duct stones.
• Do not use if you have or suspect you have a blockage in the bile ducts or any other obstruction in the biliary tract.
• Discontinue use if you develop symptoms such as persistent abdominal pain, jaundice, or dark urine, and seek medical attention immediately.

The side effects of Chelidonium Majus Extract Tablet may include:

• Skin rash or itching
• Allergic reactions
• Stomach pain or discomfort
• Nausea and vomiting
• Diarrhea
• Dizziness or lightheadedness
• Dry mouth
• Fatigue and weakness

Following are the precautions and warnings for Chelidonium Majus Extract Tablet:

• This medication should not be used by individuals with a known sensitivity or allergy to Chelidonium Majus or any of its components.
• Not recommended for children under 12 years old due to potential toxicity and lack of safety data.
• Patients with liver or kidney disease should exercise caution and consult a healthcare professional before use.
• May cause photosensitivity; avoid excessive sunlight exposure and use sunscreen when outdoors.
• Discontinue use and seek medical attention if you experience any signs of liver problems such as jaundice, dark urine, or abdominal pain.
• Pregnant and breastfeeding women should consult a healthcare professional before taking this medication as it may have potential risks.
• If you are taking other medications, especially those metabolized by the liver, consult a healthcare provider to avoid potential interactions.
• Do not exceed the recommended dosage as it may lead to adverse effects, including severe liver and kidney damage.

Following are the drug interactions for Chelidonium Majus Extract Tablet:

• May interact with cytochrome P450 (CYP) enzyme inducers such as rifampicin, potentially reducing the effectiveness of Chelidonium Majus.
• Can inhibit the metabolism of CYP3A4 substrates, leading to increased levels of medications like simvastatin, lovastatin, and cyclosporine.
• Combining with St. John's Wort (Hypericum perforatum) may reduce the efficacy of Chelidonium Majus due to induction of CYP enzymes.
• Anticoagulant and antiplatelet drugs, including warfarin and clopidogrel, could have their effects enhanced, increasing the risk of bleeding.
• It may interact with medications metabolized by CYP2D6, potentially altering the effectiveness of drugs like metoprolol and tramadol.
• Opioid analgesics may have their effects reduced, requiring dosage adjustments when used with Chelidonium Majus.
• The effectiveness of certain antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs), might be affected due to CYP enzyme interactions.

Following are the food interactions to be aware of when taking Chelidonium Majus Extract Tablets:

• Avoid consuming grapefruit or grapefruit juice as they may interfere with the metabolism of the drug, potentially leading to increased side effects.
• Alcohol consumption should be limited as it can enhance the sedative effects of the extract, causing increased drowsiness and impaired coordination.
• Caffeine-rich foods and beverages, such as coffee, tea, and energy drinks, should be consumed in moderation as they may affect the liver's ability to process the extract.
• High-fat meals might delay the absorption of the active compounds, potentially reducing the effectiveness of the medication.
• Spicy foods may irritate the digestive system and potentially exacerbate any gastrointestinal side effects associated with the extract.
• Avoid excessive consumption of sugary foods and beverages as they can impact the overall health and effectiveness of the herbal remedy.
• Consult with a healthcare professional or pharmacist for specific dietary recommendations tailored to your medication regimen.
• Always follow the dosage instructions provided by your healthcare provider for optimal results and minimal food-related interactions.

Chelidonium Majus Extract Tablets should be stored in a secure and dry location, protected from light and moisture. It is crucial to maintain the tablets in their original packaging, ensuring the container is tightly sealed to prevent contamination. Avoid exposing the tablets to extreme temperatures by storing them away from heat sources like radiators or direct sunlight. Always verify the expiration date on the packaging, and when disposing of the tablets, do not flush them or pour them down the drain. Instead, follow local guidelines or consult a pharmacist for safe disposal methods. Keep this medication away from children to prevent accidental consumption. Proper storage and disposal practices are essential to maintain the integrity of the medication and ensure safety.

Following are the quick tips for Chelidonium Majus Extract Tablet:

• Consult a healthcare professional for personalized advice and dosage recommendations.
• Ensure you understand the dosage instructions and take the tablets as directed.
• Maintain a consistent schedule for taking the tablets for best results.
• Take the tablets with a full glass of water to aid in swallowing.
• Avoid crushing or chewing the tablets; swallow them whole.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.
• Do not share your medication with others, even if they have similar symptoms.