Vitamin D3 (600000IU) 1ml, 1 Ampoule Injection

Cholecalciferol 600,000 IU injection, also known as vitamin D3, has a straightforward mechanism of action. When administered, it is rapidly absorbed and enters the bloodstream. Cholecalciferol is biologically inert and requires metabolic activation in the liver and kidneys to form its active form, calcitriol (1,25-dihydroxyvitamin D). Calcitriol binds to the vitamin D receptor (VDR) in various target tissues, primarily the intestines, kidneys, and bones. This binding triggers a cascade of intracellular events, leading to increased intestinal absorption of calcium and phosphorus, promoting bone mineralization and maintaining serum calcium and phosphorus levels within the normal range. This mechanism is crucial for the development and maintenance of healthy bones and teeth.

Cholecalciferol 600,000iu

Vitamin D analog

injection

The following are the uses of Cholecalciferol 600,000iu injection:

• Used for treating vitamin D deficiency, ensuring proper bone development and preventing conditions like rickets.
• Used to promote calcium absorption, essential for maintaining strong and healthy bones.
• Used in the management of hypocalcemia (low calcium levels) to restore balance.
• Used for individuals with limited sun exposure, ensuring adequate vitamin D production.
• Used as a supplement during pregnancy and breastfeeding to support fetal bone development.
• Used to prevent and treat osteoporosis, reducing the risk of fractures.
• Used in the treatment of certain bone disorders, aiding in proper mineralization.
• Used to support overall immune system function, as vitamin D plays a role in immune response.

In the case of an overdose of Cholecalciferol 600,000 IU injection, symptoms may include nausea, vomiting, weakness, and an elevated calcium level in the blood. Excessive vitamin D intake can lead to hypercalcemia, causing potential harm to the kidneys and other organs. Seek medical advice promptly if an overdose is suspected, as treatment may involve rehydration and close monitoring of calcium and kidney function to prevent further complications. Timely intervention is key to managing the effects of such an overdose.

In the case of a missed dose of Cholecalciferol 600,000 IU injection, it is important to administer the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, consult your healthcare professional for advice on how to resume your treatment safely. It is essential to maintain a consistent dosing schedule for the best therapeutic effect.

To administer Cholecalciferol 600,000iu injection, clean the injection site with an alcohol swab, insert the needle at a 90-degree angle, and slowly inject the entire content of the vial intramuscularly, ensuring the injection is given into the muscle as directed by your healthcare provider.

Cholecalciferol 600,000 IU injection should not be used in the following conditions:

• Hypersensitivity to cholecalciferol (vitamin D3) or any components of the injection.
• Hypercalcemia or conditions associated with high calcium levels, such as hyperparathyroidism or certain cancers.
• Hypervitaminosis D, as additional vitamin D can worsen the condition.
• Severe renal impairment or kidney stones, especially those related to calcium oxalate.
• Sarcoidosis or other granulomatous disorders that can increase sensitivity to vitamin D.
• Individuals taking high doses of calcium supplements or other medications containing vitamin D without medical supervision.
• Patients with conditions that require careful monitoring of calcium and phosphorus levels, such as certain types of kidney disease.

The side effects of Cholecalciferol 600,000 IU injection may include:

• Nausea and vomiting
• Weakness and fatigue
• Dry mouth
• Metallic taste
• Loss of appetite
• Constipation or diarrhea
• Muscle or joint pain
• Increased thirst and urination

Following are the precautions and warnings for Cholecalciferol 600,000 IU injection:

• Allergic reactions may occur; immediate medical attention is necessary if symptoms like difficulty breathing, swelling of the face, lips, throat, or tongue are experienced.
• Not recommended for individuals with vitamin D toxicity or hypercalcemia (high calcium levels in the blood).
• Should be used with caution in patients with kidney stones, kidney disease, or conditions causing high calcium levels.
• Regular monitoring of calcium levels in the blood is essential during prolonged treatment.
• May cause dizziness; patients should avoid driving or operating machinery if affected.
• Elderly patients may be more sensitive to the side effects, particularly hypercalcemia.
• Not suitable for intravenous (IV) injection; must be administered intramuscularly as directed by a healthcare professional.

Following are the drug interactions for Cholecalciferol 600,000 IU injection:

• Anticonvulsants like phenobarbital, phenytoin, and carbamazepine can reduce the effectiveness of cholecalciferol by increasing its metabolism.
• Cholestyramine and colestipol can decrease the absorption of vitamin D, potentially reducing its effectiveness.
• Thiazide diuretics may increase calcium levels, and concurrent use with cholecalciferol may require monitoring and dosage adjustments.
• Orlistat and fat substitutes can reduce the absorption of fat-soluble vitamins like vitamin D, leading to potential deficiency.
• Calcium carbonate and calcium supplements can compete for absorption with cholecalciferol, affecting overall calcium and vitamin D levels.
• Aluminum-containing antacids may decrease the absorption of vitamin D, potentially requiring monitoring.
• Drugs that affect bone metabolism, such as bisphosphonates and denosumab, may require vitamin D supplementation, and their effects should be monitored.

Following are the food interactions for Cholecalciferol 600,000 IU injection:

• Consuming high-fat meals after the injection may enhance the absorption of Cholecalciferol, as vitamin D is fat-soluble.
• Dairy products, especially milk, can reduce the absorption of Cholecalciferol due to the presence of calcium, which may bind with vitamin D.
• Foods rich in vitamin D, such as fatty fish, egg yolks, and fortified foods, should be consumed with caution as they may lead to excessive vitamin D levels when combined with the injection.
• Avoid excessive alcohol consumption as it may impair the liver's ability to metabolize vitamin D, potentially affecting its effectiveness.
• Calcium-rich foods like broccoli, kale, and tofu may be beneficial as they can help maintain calcium levels, which are crucial for vitamin D's bone-strengthening effects.
• Certain mineral oils and cholesterol-lowering drugs can interfere with vitamin D absorption and should be used cautiously.
• Always consult your healthcare provider regarding dietary adjustments and potential interactions with specific foods or supplements.

Cholecalciferol 600,000iu injection should be stored in a secure and controlled environment, preferably in a designated pharmaceutical storage area. It is crucial to maintain a cool and dry storage location, ensuring the temperature remains consistent and does not exceed room temperature. Protect the injection from direct exposure to sunlight, as it can degrade the medication. Always keep the medication in its original packaging, tightly sealed, to maintain its integrity and prevent contamination. Regularly check the expiration date on the packaging, and dispose of any expired or unused injections promptly. When disposing of the medication, do not flush it down the toilet or pour it into drains. Instead, follow local guidelines or consult healthcare professionals for appropriate disposal methods to minimize environmental impact. Lastly, ensure that the storage area is inaccessible to children to prevent accidental exposure or ingestion.

Following are the quick tips for Cholecalciferol 600,000iu injection:

• Administer the injection under medical supervision as directed by your healthcare provider.
• Ensure the injection is prepared and administered by trained medical personnel.
• Follow the prescribed dosage and administration schedule provided by your doctor.
• Do not inject if the solution is cloudy or contains particles.
• Dispose of used needles and syringes safely in designated sharps containers.
• Store the injection as directed on the packaging, typically at room temperature away from direct sunlight.
• Inform your doctor if you have any allergies or medical conditions before receiving the injection.
• Report any persistent or severe side effects to your healthcare provider promptly.