VITAMIN K TAB

Vitamin K tablet, specifically containing Vitamin K1 (phylloquinone), has a straightforward mechanism of action. Its primary role is to act as a cofactor for the enzyme gamma-glutamyl carboxylase, which is responsible for the post-translational modification of glutamate residues in certain proteins to form gamma-carboxyglutamate (Gla) residues. This process is known as carboxylation. The Gla residues are essential for the biological activity of several proteins involved in blood coagulation, including factors II (prothrombin), VII, IX, and X, as well as proteins C and S. When Vitamin K is present, it enables the carboxylation of these proteins, allowing them to bind to calcium ions and undergo conformational changes, which are crucial for their proper functioning in the blood clotting cascade. This mechanism ensures the body's ability to control bleeding and maintain hemostasis effectively.

Antidote/Vitamin K.

Tablet

The following are the uses of Vitamin K Tablet:

• Used for promoting healthy blood clotting and preventing excessive bleeding.
• Used to support bone health and reduce the risk of fractures, especially in older individuals.
• Used for treating vitamin K deficiency, ensuring proper blood coagulation.
• Used in newborn care to prevent bleeding-related complications.
• Used to enhance cardiovascular health by regulating calcium levels.
• Used to potentially reduce bruising and support wound healing.
• Used to maintain optimal liver function, as it plays a role in vitamin K metabolism.
• Used as a supplement during certain medical treatments or surgeries to manage bleeding risks.

In the case of an overdose of Vitamin K Tablets, individuals may experience symptoms such as flushing, sweating, dizziness, and gastrointestinal discomfort. The severity of these symptoms can vary depending on the amount ingested. It is important to contact a healthcare professional or a poison control center for guidance on managing an overdose. They can provide specific instructions and recommendations based on the individual's situation, ensuring appropriate medical care and monitoring.

In the case of a missed dose of Vitamin K Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication regimen. Consult your healthcare provider if you have any concerns or questions about managing missed doses.

To take the Vitamin K Tablet, place the tablet on your tongue and swallow it with a glass of water, preferably during or after a meal to enhance absorption. It is recommended to take the tablet as directed by your healthcare provider, usually once a day, at around the same time each day to maintain consistent levels of Vitamin K in your body.

Following are the conditions/situations when Vitamin K Tablet should not be used:

• Should not be used in individuals with a known allergy to Vitamin K or any of its ingredients.
• Contraindicated in patients with a history of hypersensitivity reactions to Vitamin K injections.
• Not suitable for individuals with liver disease or conditions affecting liver function, as it can affect Vitamin K metabolism.
• Should be used with caution in patients with a history of blood clots or thromboembolic disorders.
• Not recommended for those with a rare genetic problem of galactose intolerance, glucose-galactose malabsorption, or Lapp lactase deficiency.
• Avoid using if you have a known sensitivity to any of the tablet's excipients.
• Contraindicated in patients with a history of severe allergic reactions to any medications.

The side effects of Vitamin K Tablet may include:

• Skin rashes or itching
• Allergic reactions, such as hives or swelling
• Nausea and vomiting
• Diarrhea
• Abdominal pain or discomfort
• Loss of appetite
• Fatigue or weakness
• Jaundice (yellowing of the skin or eyes)

Following are the precautions and warnings:

• Vitamin K tablets should not be taken if you have a known allergy or hypersensitivity to vitamin K or any of its derivatives.
• Patients with liver disease or a history of jaundice should exercise caution and consult a healthcare professional before use, as vitamin K metabolism may be affected.
• Those with a history of blood clotting disorders or those taking anticoagulant medications should be monitored closely as vitamin K can affect blood clotting.
• If you are pregnant or breastfeeding, consult your doctor before taking vitamin K tablets, as they can pass into breast milk.
• This medication may interact with other drugs, including anticoagulants, so inform your doctor about all medications you are taking.
• Do not exceed the recommended dosage, as high doses of vitamin K can lead to adverse effects.
• Keep vitamin K tablets out of reach of children, and store them in a cool, dry place to maintain their potency.

Following are the drug interactions for Vitamin K Tablet:

• Anticoagulants like warfarin may have reduced effects when taken with Vitamin K, as Vitamin K is essential for blood clotting. Close monitoring of INR (International Normalized Ratio) is necessary.
• Salicylates (e.g., aspirin) and certain antibiotics (e.g., cephalosporins) can decrease the absorption of Vitamin K, potentially reducing its effectiveness.
• Cholestyramine, a bile acid sequestrant, can bind to Vitamin K and reduce its absorption, leading to decreased Vitamin K levels.
• Mineral oil, when used as a laxative, may interfere with the absorption of Vitamin K, especially with long-term use.
• Some anticonvulsant medications, such as phenytoin and carbamazepine, can decrease Vitamin K levels, potentially affecting blood clotting.
• Long-term use of broad-spectrum antibiotics may reduce the synthesis of Vitamin K by gut bacteria, which is a natural source of the vitamin.
• Orlistat, a weight-loss medication, may decrease the absorption of fat-soluble vitamins, including Vitamin K, leading to potential deficiencies.
• High doses of Vitamin A and Vitamin E may interfere with Vitamin K metabolism and increase the risk of bleeding.

Following are the food interactions for Vitamin K Tablet:

• Green leafy vegetables like spinach, kale, and broccoli, as well as vegetable oils, are rich in Vitamin K and can enhance the effects of the tablet, leading to potential over-coagulation.
• Consuming excessive amounts of Vitamin K-rich foods like liver, fish, eggs, and meat may interfere with the medication's intended action, especially in patients with liver issues.
• Soybean oil and canola oil are high in Vitamin K and might reduce the tablet's effectiveness if consumed in large quantities.
• Avoid cranberry juice as it may decrease the absorption of Vitamin K, impacting the medication's efficacy.
• Consuming large amounts of garlic can increase the risk of bleeding, especially if you are taking high doses of Vitamin K.
• Vitamin E supplements can interfere with Vitamin K absorption, so consult your doctor if you're taking both.
• Ensure a balanced diet and consider consulting a dietician to manage your Vitamin K intake effectively.

Store Vitamin K Tablets in a cool, dry place, preferably at room temperature, ensuring protection from light and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. Avoid exposing the medication to extreme temperatures, such as those found in bathrooms or near heat sources like stoves or radiators. Regularly check the expiration date, and properly dispose of any unused or expired tablets; refrain from flushing them down the toilet or pouring them into drains. Consult your pharmacist or healthcare provider for appropriate disposal methods, and ensure the medication is stored safely away from children to prevent accidental consumption. Proper storage and disposal are crucial for maintaining the effectiveness and safety of Vitamin K Tablets.

Following are the quick tips for Vitamin K Tablet:

• Take the tablet as directed by your doctor or pharmacist.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• Take with or after food to prevent stomach upset.
• Maintain a consistent schedule for taking the tablet, preferably at the same time each day.
• If you miss a dose, take it as soon as you remember, unless it's almost time for your next dose.
• Do not double the dose to make up for a missed one.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.