Vitane-D Tab 20s

Cholecalciferol, also known as vitamin D3, has a specific mechanism of action. When ingested, cholecalciferol undergoes two hydroxylation reactions in the body to become its active form, calcitriol (1,25-dihydroxyvitamin D3). The first hydroxylation occurs in the liver, converting cholecalciferol to 25-hydroxyvitamin D3 (calcifediol). Subsequently, the kidneys perform the second hydroxylation, transforming calcifediol into the biologically active calcitriol. Calcitriol exerts its primary effect by binding to the vitamin D receptor (VDR) found in various target cells. This binding initiates a cascade of intracellular events, leading to the regulation of gene expression. The VDR-calcitriol complex influences the transcription of genes involved in calcium and phosphate homeostasis, promoting calcium absorption in the intestines, renal reabsorption of calcium, and the mobilization of calcium from bones, thereby playing a crucial role in maintaining proper bone mineralization and overall calcium balance in the body.

Cholecalciferol 1,000iu

Vitamin D supplement

Tablet

The following are the uses of Cholecalciferol 1,000iu Tablet:

• Used for treating and preventing Vitamin D deficiency.
• Used to support bone health and promote calcium absorption.
• Used in cases of impaired Vitamin D metabolism.
• Used to manage conditions like rickets and osteomalacia.
• Used to enhance immune function and overall well-being.
• Used for individuals with limited sun exposure or malabsorption issues.
• Used as a supplement during pregnancy and breastfeeding for maternal and fetal bone health.
• Used to reduce the risk of fractures and support muscle strength.

The following dosage regimen is to be followed:

• Adults

The Recommended Dietary Allowance for adults is 600 IU daily

• Geriatric

The RDA for people 70 years or above is 800 IU daily

• Children

To be used as per doctor's recommendation

In the case of an overdose of Cholecalciferol 1,000iu Tablets, it is important to recognize the signs and symptoms, which may include nausea, vomiting, constipation, and an elevated calcium level in the blood. Prompt action should be taken by contacting a healthcare professional or poison control center for guidance. They will provide specific instructions on managing the overdose, which may include inducing vomiting or administering appropriate medical treatment to counteract the effects of the excess vitamin D.

In the case of a missed dose of Cholecalciferol 1,000iu Tablet, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, consult your healthcare provider for guidance on how to adjust your dosage and get back on track with your treatment plan.

To take Cholecalciferol 1,000iu Tablet, place the tablet on your tongue and swallow it with a glass of water, preferably with a meal or as directed by your healthcare professional, ensuring you follow the recommended dosage instructions provided.

Here are the situations when Cholecalciferol 1,000 IU Tablet should not be used:

• Do not take if you have a known hypersensitivity or allergy to Cholecalciferol or any other vitamin D analogues.
• Avoid if you have hypervitaminosis D, a condition where there is an excess of vitamin D in the body.
• Not suitable for individuals with hypercalcemia, which is high calcium levels in the blood.
• Should not be used in patients with kidney stones or conditions that increase the risk of high calcium levels.
• Contraindicated in those with evidence of vitamin D toxicity.
• Do not use if you have a condition called hypercalciuria, where there is excessive calcium in the urine.
• Avoid if you have a history of kidney disease or are currently on kidney dialysis.

The side effects of Cholecalciferol 1,000 IU Tablet may include:

• Nausea and vomiting.
• Constipation or diarrhea.
• Dry mouth.
• Metallic taste in the mouth.
• Fatigue and weakness.
• Muscle or joint pain.
• Excessive thirst and frequent urination.
• Confusion and mood changes.

Following are the precautions and warnings for Cholecalciferol 1,000iu Tablet:

• Do not exceed the recommended dosage, as high doses of Vitamin D can lead to hypervitaminosis D and potential toxicity.
• Regular monitoring of calcium and phosphate levels is necessary, especially in patients with kidney disease or those on long-term treatment.
• Patients with hypercalcemia or conditions that cause hypercalcemia should use this medication with caution.
• Individuals with a history of kidney stones should be monitored, as high doses of Vitamin D may increase the risk.
• Cholecalciferol can interact with certain medications, including digoxin, thiazide diuretics, and steroids, so consult a healthcare professional before use.
• Avoid taking other Vitamin D supplements or calcium-rich antacids without medical advice to prevent excessive intake.
• Not recommended for individuals with hyperparathyroidism or evidence of Vitamin D toxicity.
• Always consult a healthcare provider before using this medication if you are pregnant, breastfeeding, or have any underlying medical conditions.

Following are the drug interactions for Cholecalciferol 1,000iu Tablet:

• It can interact with antacids containing magnesium, as these may decrease the absorption of cholecalciferol, leading to reduced effectiveness.
• Thiazide diuretics can reduce the excretion of vitamin D, which may result in hypercalcemia when used with cholecalciferol.
• Cholestyramine can bind to cholecalciferol in the intestine, preventing its absorption, thus reducing its effectiveness.
• Phenytoin, phenobarbital, and rifampin may increase the metabolism of vitamin D, leading to decreased calcium absorption.
• Calcium channel blockers, like verapamil, can increase the risk of hypercalcemia when used with cholecalciferol.
• Corticosteroids may decrease the effectiveness of cholecalciferol by reducing calcium absorption in the intestines.
• Orlistat, a weight-loss medication, can decrease the absorption of fat-soluble vitamins, including vitamin D, requiring careful monitoring.

Following are the food interactions for Cholecalciferol 1,000 IU Tablet:

• Consuming high-fat meals can enhance the absorption of Cholecalciferol, as vitamin D is fat-soluble. Consider taking the supplement with a meal containing healthy fats.
• Avoid excessive alcohol consumption as it may interfere with vitamin D metabolism and reduce its effectiveness.
• Maintain a balanced diet rich in calcium and phosphorus, as these minerals work synergistically with vitamin D for optimal bone health.
• Grapefruit and its juice may affect the metabolism of some medications, but it typically does not impact Cholecalciferol directly.
• Avoid excessive intake of vitamin A-rich foods, as high levels of vitamin A can interfere with vitamin D metabolism.
• Some foods like fatty fish (salmon, mackerel), egg yolks, and fortified dairy products naturally contain vitamin D, so consider your overall dietary intake when taking supplements.
• Certain fortified foods and drinks (cereals, milk, orange juice) may contribute to your daily vitamin D intake, ensuring you don't exceed recommended levels.
• Always consult a healthcare professional for personalized advice, especially if you have specific dietary restrictions or medical conditions.

Cholecalciferol 1,000iu Tablets should be stored in a cool and dry environment, preferably at room temperature, ensuring protection from light and moisture. The original packaging should be tightly sealed to maintain the integrity of the medication. It is crucial not to expose the tablets to extreme temperatures, so avoid storage in places like bathrooms, near ovens, or on windowsills. Always check the expiration date, and if the medication is no longer needed or has expired, proper disposal is essential. Do not dispose of the tablets by flushing or pouring them down the drain; instead, seek guidance from a pharmacist or healthcare professional for safe disposal methods. Keep the medication securely stored away from children to prevent accidental consumption.

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Following are the quick tips for Cholecalciferol 1,000iu Tablet:

• Consult your doctor before taking this medication, especially if you have a medical condition or are taking other supplements.
• Take the tablet as directed by your healthcare provider, usually once daily or as prescribed.
• Swallow the tablet whole with a glass of water; do not crush, chew, or break it.
• Take the tablet with a meal to enhance absorption, preferably during your main meal of the day.
• Maintain a consistent schedule for taking the tablet to ensure stable vitamin D levels.
• Avoid taking other vitamin D supplements or calcium supplements without medical advice.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.