VitaNor-D (10000IU) 1ml, 1 Ampoule Injection

Cholecalciferol, also known as vitamin D3, has a mechanism of action that primarily involves its role in calcium and phosphate homeostasis. When administered as an injection, Cholecalciferol 10,000 IU acts by binding to the vitamin D receptor (VDR) in various target tissues. This binding activates the VDR, which then forms a heterodimer with the retinoid X receptor (RXR). The VDR-RXR complex regulates the expression of genes involved in calcium and phosphate metabolism, particularly in the intestine, kidneys, and bones. It enhances intestinal absorption of calcium and phosphate by increasing the efficiency of active transport across the intestinal epithelium. In the kidneys, it promotes calcium reabsorption and reduces phosphate excretion. Additionally, Cholecalciferol plays a crucial role in bone mineralization by stimulating osteoblasts to produce osteocalcin, a protein essential for the proper deposition of calcium and phosphate in the bone matrix.

Cholecalciferol 10,000iu

Vitamin D analog

Injection

The following are the uses of Cholecalciferol 10,000iu injection:

• Used for treating and preventing Vitamin D deficiency, ensuring adequate levels for overall health.
• Used for bone health, aiding in calcium absorption and maintaining strong bones.
• Used for managing osteoporosis, reducing the risk of fractures and improving bone density.
• Used for supporting immune function, as Vitamin D plays a role in immune regulation.
• Used for enhancing muscle strength and reducing the risk of falls, especially in older adults.
• Used for regulating mood and cognitive function, as Vitamin D receptors are present in the brain.
• Used for supporting cardiovascular health, as Vitamin D deficiency is linked to heart-related issues.
• Used for managing certain skin conditions, as Vitamin D has anti-inflammatory properties.

In the case of an overdose of Cholecalciferol 10,000 IU injection, symptoms may include nausea, vomiting, weakness, and an elevated calcium level in the blood. Prompt medical attention is necessary, and healthcare professionals should be contacted immediately. Treatment for overdose may involve managing symptoms and potentially using specific medications to counteract the effects of excessive vitamin D. It is crucial to follow the prescribed dosage and not exceed the recommended amount to prevent such incidents.

In the case of a missed dose of Cholecalciferol 10,000 IU injection, it is important to administer the medication as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to resume the medication safely. It is recommended to set reminders or use a medication tracker to help you stay on track with your injections.

To administer Cholecalciferol 10,000iu injection, clean the injection site with an alcohol swab, insert the needle at a 90-degree angle, and slowly inject the prescribed dose subcutaneously or intramuscularly as directed by your healthcare provider.

Following are the conditions/situations when Cholecalciferol 10,000 IU injection should not be administered:

• Should not be used in individuals with a known hypersensitivity or allergy to Cholecalciferol or any of the excipients in the injection.
• Contraindicated in patients with hypercalcemia (high levels of calcium in the blood) or conditions that lead to elevated calcium levels, such as primary hyperparathyroidism.
• Not recommended for individuals with a history of kidney stones or conditions that increase the risk of high calcium levels, such as sarcoidosis or hypervitaminosis D.
• Should not be used in patients with vitamin D toxicity or those who have conditions that cause excessive calcium absorption, such as Williams syndrome.
• Contraindicated in individuals with a history of calcification of blood vessels or soft tissues.
• Not suitable for patients with uncontrolled hyperphosphatemia (high levels of phosphate in the blood).

The side effects of Cholecalciferol 10,000 IU injection may include:

• Nausea and vomiting
• Weakness and fatigue
• Dry mouth
• Metallic taste
• Loss of appetite
• Constipation
• Muscle or bone pain

Following are the precautions and warnings for Cholecalciferol 10,000 IU injection:

• Not recommended for individuals with hypersensitivity or known allergy to Cholecalciferol or any of its excipients.
• Patients with kidney disease or kidney stones should use with caution and under medical supervision, as it can affect kidney function.
• Avoid excessive dosage as it may lead to hypervitaminosis D and potential harm to the heart, kidneys, and blood vessels.
• Regular monitoring of calcium and phosphate levels is necessary during prolonged treatment.
• Use with caution in patients with sarcoidosis, as it can affect calcium metabolism.
• Patients with cardiovascular disease should be monitored closely, as vitamin D may affect calcium levels in the blood.
• Not suitable for intravenous administration and should only be used as directed by a healthcare professional.
• Cholecalciferol injection may interact with certain medications; consult your doctor about all medications you are taking.

Following are the drug interactions for Cholecalciferol 10,000 IU injection:

• Thiazide diuretics can decrease the excretion of vitamin D, leading to potential hypercalcemia.
• Anticonvulsants like phenobarbital and phenytoin can accelerate the metabolism of vitamin D, reducing its effectiveness.
• Orlistat and cholestyramine can decrease the absorption of vitamin D, potentially requiring higher doses.
• Calcium channel blockers may increase the risk of hypercalcemia when used with vitamin D.
• Corticosteroids may reduce calcium absorption, affecting vitamin D metabolism.
• Aluminum-containing antacids may decrease the absorption of vitamin D, requiring careful monitoring.
• Mineral oil can interfere with the absorption of vitamin D, particularly with long-term use.

Following are the food interactions for Cholecalciferol 10,000 IU injection:

• Avoid excessive intake of vitamin D-fortified foods or supplements, as this medication already provides a high dose of vitamin D, and excessive intake can lead to vitamin D toxicity.
• Consuming fatty fish like salmon, mackerel, and tuna can enhance the absorption of Cholecalciferol, as it is a fat-soluble vitamin.
• Avoid grapefruit and grapefruit juice, as they may interfere with vitamin D metabolism and increase the risk of side effects.
• Limit calcium-rich foods like dairy products and calcium-fortified juices, as excessive calcium intake alongside high-dose vitamin D may lead to hypercalcemia.
• Alcohol should be consumed in moderation, as it can affect vitamin D metabolism and potentially reduce its effectiveness.
• Inform your healthcare provider about any vitamin D-rich foods or supplements you regularly consume to ensure proper dosage adjustment.
• Maintaining a balanced diet with a variety of foods is essential, as vitamin D works synergistically with other nutrients for optimal health.

Cholecalciferol 10,000iu injection should be stored in a secure and controlled environment, preferably in a locked cabinet or a designated medication storage area. It is crucial to maintain a cool and dry storage location, ensuring the temperature remains consistent and does not exceed room temperature. Protect the injection from direct sunlight, as it can degrade the medication. Always keep the medication in its original packaging, as it is designed to maintain stability and prevent contamination. Regularly check the expiration date on the packaging, and dispose of any expired or unused injections promptly. When disposing of the medication, do not flush it down the toilet or pour it into drains. Instead, follow local guidelines or consult healthcare professionals for appropriate disposal methods to ensure environmental safety. Keep the medication out of children's reach to prevent accidental exposure.

Following are the quick tips for Cholecalciferol 10,000iu injection:

• Ensure the injection is administered by a trained healthcare professional.
• Inform your doctor about any allergies or medical conditions before the injection.
• Follow the prescribed dosage and frequency as directed by your doctor.
• Do not inject if the solution appears cloudy or discolored.
• Rotate injection sites to minimize discomfort and tissue damage.
• Dispose of used needles and syringes safely in designated containers.
• Report any side effects or unusual symptoms promptly to your healthcare provider.
• Store the injection as directed on the packaging, away from direct sunlight.