VIVIO PLUS TAB

Diclofenac, a non-steroidal anti-inflammatory drug (NSAID), exerts its mechanism of action primarily by inhibiting cyclooxygenase (COX) enzymes, specifically COX-2. By blocking COX-2, diclofenac suppresses the production of prostaglandins, which are key mediators of inflammation and pain. This inhibition reduces the synthesis of prostaglandin precursors, resulting in decreased inflammation, pain relief, and reduced fever. Diclofenac's selectivity for COX-2 over COX-1 contributes to its anti-inflammatory and analgesic effects while minimizing the gastrointestinal side effects associated with COX-1 inhibition. The drug's ability to target COX-2 makes it an effective medication for managing conditions characterized by inflammation and pain, such as arthritis and acute injuries.

Diclofenac

Non-steroidal anti-inflammatory drug (NSAID)

Tablet

The following are the uses of Diclofenac Tablet:

• Used for relieving pain and reducing inflammation caused by conditions like arthritis, sprains, and toothaches.
• Used for managing post-operative pain and swelling.
• Used to treat acute migraines and headaches.
• Used for reducing menstrual pain and discomfort.
• Used to lower fever and ease muscle stiffness.
• Used for treating pain and inflammation in conditions affecting the musculoskeletal system.
• Used as an adjunct therapy for managing pain in chronic conditions under medical supervision.

In the case of an overdose of Diclofenac Tablets, individuals may experience symptoms such as nausea, vomiting, stomach pain, and in severe cases, gastrointestinal bleeding. It is important to seek medical advice immediately if an overdose is suspected. Treatment for overdose may involve inducing vomiting or administering activated charcoal to prevent further absorption of the medication. Prompt medical intervention can help manage these symptoms and prevent potential complications.

In the case of a missed dose of Diclofenac Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication regimen. Consult your healthcare provider if you have any concerns or if you miss multiple doses in a row.

To take the Diclofenac Tablet, swallow the tablet whole with a full glass of water, preferably with or after a meal, following the dosage instructions provided by your healthcare professional, typically taken 2-3 times a day with a gap of 4-6 hours between doses.

Here are the conditions and situations when Diclofenac Tablet should not be taken:

• Should not be used in individuals with a known allergy or hypersensitivity to Diclofenac or other non-steroidal anti-inflammatory drugs (NSAIDs).
• Contraindicated in patients with active or recent gastrointestinal bleeding or perforation.
• Not recommended for individuals with a history of asthma, hives, or allergic-type reactions triggered by aspirin or other NSAIDs.
• Should not be used in patients with severe heart failure or cardiovascular disease.
• Contraindicated in individuals with active peptic ulcer or a history of recurrent peptic ulcer/bleeding.
• Not suitable for patients with severe kidney or liver impairment.
• Should be avoided during the last trimester of pregnancy due to potential fetal risks.
• Should not be used in patients with bleeding disorders or those on anticoagulant therapy.
• Contraindicated in individuals with severe dehydration or those who have recently experienced a heart attack.
• Not recommended for individuals with systemic lupus erythematosus (SLE) or similar conditions.

The side effects of Diclofenac Tablet may include:

• Stomach pain or discomfort
• Nausea and vomiting
• Diarrhea
• Constipation
• Dizziness or vertigo
• Headache
• Skin rashes or itching
• Increased blood pressure

Following are the precautions and warnings for Diclofenac Tablet:

• Diclofenac should not be used by individuals who are allergic to non-steroidal anti-inflammatory drugs (NSAIDs) or any of the tablet's components.
• Patients with a history of gastrointestinal bleeding, ulcers, or other stomach disorders should exercise caution and consult a doctor before using this medication.
• It may increase the risk of cardiovascular events like heart attack or stroke, especially with long-term use. Monitor for symptoms and seek medical advice if you have a history of heart disease.
• Diclofenac can cause liver problems. Regular monitoring of liver function is recommended, especially during long-term treatment.
• Kidney function should be monitored as Diclofenac can affect kidney health, particularly in patients with existing kidney issues.
• This medication may increase blood pressure, so patients with hypertension should be monitored regularly.
• Avoid using Diclofenac during pregnancy and breastfeeding unless advised by a healthcare professional.
• Elderly patients may be more susceptible to side effects, and dosage adjustments might be necessary.

Following are the drug interactions for Diclofenac Tablet:

• When taken with other non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen, there is an increased risk of gastrointestinal bleeding and kidney problems.
• Diclofenac may reduce the effectiveness of angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs), used for blood pressure control.
• Concurrent use with anticoagulants (e.g., warfarin) can increase the risk of bleeding. Regular monitoring is advised.
• It can interact with diuretics, increasing the risk of kidney dysfunction, particularly with loop diuretics.
• Lithium levels may be increased when used with Diclofenac, potentially leading to lithium toxicity.
• The blood pressure-lowering effect of beta-blockers may be reduced by Diclofenac.
• Combining with corticosteroids can increase the risk of gastrointestinal bleeding and delay wound healing.

Following are the food interactions for Diclofenac Tablet:

• Alcohol consumption should be avoided or limited as it can increase the risk of gastrointestinal bleeding and liver problems.
• Grapefruit and grapefruit juice are to be avoided as they may interfere with the metabolism of Diclofenac, leading to increased drug levels and potential toxicity.
• Dairy products like milk and cheese might reduce the absorption of Diclofenac, so it is advisable to take the medication with water or as directed by the healthcare professional.
• Avoid high-fat meals as they can delay the absorption of Diclofenac, potentially affecting its onset of action.
• Salt substitutes containing potassium should be used with caution as Diclofenac can increase potassium levels in the blood.
• Limit or avoid caffeine intake as it can increase the risk of nervousness and sleep disturbances, especially when taken in excess.
• Avoid foods fortified with vitamin K (like green leafy vegetables) as Diclofenac may reduce the effectiveness of vitamin K, affecting blood clotting.
• Always take the medication with a full glass of water to ensure proper absorption and reduce the risk of gastrointestinal side effects.

Diclofenac Tablets should be stored in a secure and dry location, preferably in their original container, away from direct sunlight and moisture. Maintain a consistent room temperature, avoiding excessive heat or cold. It is crucial to keep the medication out of the reach of children and pets to prevent accidental ingestion. Always check the expiration date, and never use the tablets beyond this date. When disposing of unused or expired tablets, do not throw them in the trash or flush them down the toilet. Instead, follow local guidelines for pharmaceutical waste disposal or consult a pharmacist for guidance on safe and environmentally friendly disposal methods. Proper storage and disposal practices ensure the effectiveness of the medication and contribute to environmental protection.

Following are the quick tips for Diclofenac Tablet:

• Consult your doctor before taking this medication, especially if you have any medical conditions or allergies.
• Take the tablet with or after food to prevent stomach irritation.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• Avoid alcohol consumption as it may increase the risk of stomach bleeding.
• Inform your doctor about all medications you are taking to prevent potential drug interactions.
• Do not exceed the prescribed dosage, and complete the full course of medication.
• Store the tablets in a cool, dry place, away from direct sunlight.