Volinza (100mg/5ml) 60ml Suspension

Diclofenac Sodium 100mg Syrup/Suspension exerts its anti-inflammatory, analgesic, and antipyretic effects through its primary mechanism of action, which is the inhibition of prostaglandin synthesis. It achieves this by blocking cyclooxygenase (COX) enzymes, particularly COX-2, which are involved in the conversion of arachidonic acid to prostaglandin H2, a precursor of various prostaglandins. By reducing prostaglandin production, diclofenac decreases inflammation, pain, and fever. This mechanism of action makes diclofenac effective in managing conditions such as rheumatoid arthritis, osteoarthritis, and other inflammatory conditions where prostaglandins play a significant role in the pathophysiology.

Diclofenac Sodium 100mg

NSAID (Non-steroidal anti-inflammatory drug)

Suspension

The following are the uses of Diclofenac Sodium 100mg Syrup/Suspension:

• Used for managing acute pain and reducing inflammation
• Used for treating post-operative pain and swelling
• Used to alleviate pain and discomfort in conditions like gout, arthritis, and sprains
• Effective for relieving menstrual cramps and pain
• Helps reduce fever and discomfort in viral infections
• Used for short-term pain relief in cases of injury or dental procedures
• Provides relief from headache and migraine symptoms

In the case of an overdose of Diclofenac Sodium 100mg Syrup/Suspension, several symptoms may occur, including nausea, vomiting, stomach pain, and in severe cases, gastrointestinal bleeding. The severity of the overdose symptoms depends on the amount ingested and individual sensitivity. It is crucial to seek medical advice immediately if an overdose is suspected, as prompt treatment can prevent potential complications and ensure the best possible outcome. Quick action is vital for effective management.

In the case of a missed dose of Diclofenac Sodium 100mg Syrup/Suspension, it is generally advised to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Avoid taking a double dose to make up for a missed one, as this may increase the risk of side effects. It is important to maintain a consistent medication routine, but if you frequently miss doses, inform your healthcare provider for further guidance.

To take Diclofenac Sodium 100mg Syrup/Suspension, shake the bottle well, measure the prescribed dose with the provided measuring cup, and administer it orally, following the recommended dosage instructions provided by your healthcare professional.

Following are the conditions/situations when Diclofenac Sodium 100mg Syrup/Suspension should not be used:

• Do not use if you have a known allergy or hypersensitivity to Diclofenac or other non-steroidal anti-inflammatory drugs (NSAIDs).
• Contraindicated in individuals with active or suspected gastrointestinal bleeding or perforation.
• Avoid if you have a history of severe heart-related conditions such as heart attack, angina, or recent bypass surgery.
• Not recommended for individuals with severe kidney or liver disease.
• Should not be used in patients with a history of asthma or severe allergic reactions triggered by aspirin or other NSAIDs.
• Contraindicated in patients with bleeding disorders or those taking anticoagulant medications.
• Do not use if you have a history of stomach ulcers or gastrointestinal bleeding.
• Not suitable for individuals with severe dehydration or low fluid volume.

The side effects of Diclofenac Sodium 100mg Syrup/Suspension may include:

• Stomach pain or discomfort
• Nausea and vomiting
• Diarrhea
• Constipation
• Dizziness or vertigo
• Skin rashes or itching
• Increased blood pressure
• Headache

Following are the precautions and warnings for Diclofenac Sodium 100mg Syrup/Suspension:

• Not suitable for individuals with a known hypersensitivity or allergy to Diclofenac or other non-steroidal anti-inflammatory drugs (NSAIDs).
• Patients with a history of gastrointestinal bleeding, peptic ulcers, or other gastrointestinal disorders should exercise caution and consult a healthcare professional before use.
• May cause an increased risk of cardiovascular events such as heart attack or stroke, especially in patients with pre-existing cardiovascular disease.
• Not recommended for long-term use; prolonged use may increase the risk of gastrointestinal and cardiovascular side effects.
• Elderly patients may be more susceptible to side effects; dosage adjustments might be necessary.
• Caution is advised when using Diclofenac with other medications, especially anticoagulants, as it may increase the risk of bleeding.
• Patients with liver or kidney disease should be closely monitored while taking Diclofenac, as it can affect these organs.

Following are the drug interactions for Diclofenac Sodium 100mg Syrup/Suspension:

• Concomitant use with other non-steroidal anti-inflammatory drugs (NSAIDs) may increase the risk of gastrointestinal bleeding and kidney problems.
• Avoid combining with angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) as it may decrease their effectiveness and increase the risk of kidney issues.
• Potential interaction with anticoagulants like warfarin, enhancing bleeding risk. Close monitoring is necessary.
• When taken with diuretics, especially loop diuretics, the risk of kidney damage increases.
• Methotrexate levels may rise when used together, requiring careful monitoring.
• Lithium levels may be affected, increasing the risk of lithium toxicity.
• Corticosteroids can increase the risk of gastrointestinal bleeding when used with Diclofenac.

Following are the food interactions for Diclofenac Sodium 100mg Syrup/Suspension:

• Alcohol consumption should be avoided as it can increase the risk of gastrointestinal bleeding and liver toxicity when combined with Diclofenac.
• Grapefruit and grapefruit juice should be consumed with caution as they may interfere with the metabolism of Diclofenac, potentially increasing its blood levels and the risk of side effects.
• Avoid high-sodium foods as Diclofenac can cause sodium retention, and excessive sodium intake may worsen hypertension and fluid retention.
• Limit caffeine intake as it may increase the risk of gastrointestinal irritation and bleeding when taken with Diclofenac.
• Avoid fatty or greasy foods, as Diclofenac can cause gastrointestinal issues, and fatty meals may delay or reduce its absorption.
• There is no specific interaction with dairy products, but some individuals may experience stomach discomfort, and it's best to monitor tolerance.
• Ensure adequate fluid intake to reduce the risk of kidney-related side effects, especially if you have pre-existing kidney conditions.
• Consult your healthcare provider if you have specific dietary concerns or are taking other medications that may interact with Diclofenac.

Diclofenac Sodium 100mg Syrup/Suspension should be stored with care to ensure its effectiveness and safety. Keep the medication in a cool, dry place, preferably at room temperature, and away from direct sunlight or excessive heat. Protect the syrup by keeping it in its original container, tightly sealed, to maintain its integrity and prevent contamination. It is crucial not to store it in the bathroom due to moisture concerns. Always be mindful of the expiration date, and if the syrup is past its prime or no longer needed, do not flush it or pour it down the drain. Contact your pharmacist or healthcare provider for instructions on safe disposal methods. Keep this medication away from children to prevent accidental consumption.

Following are the quick tips for Diclofenac Sodium 100mg Syrup/Suspension:

• Ensure you take the syrup as directed by your doctor or pharmacist.
• Administer the correct dose using an accurate measuring device.
• Take the syrup with food to minimize stomach irritation.
• Avoid lying down immediately after taking the syrup to prevent reflux.
• Stay hydrated by drinking plenty of fluids while taking this medication.
• Store the syrup at room temperature, away from direct sunlight and moisture.
• Do not share your medication with others, even if they have similar symptoms.
• Inform your healthcare provider if you have any medical conditions or allergies before taking this syrup.