Voltral Emulgel (1%) 20g Gel

Diclofenac diethylamine 1% is a topical analgesic with anti-inflammatory properties. This non-steroidal anti-inflammatory drug (NSAID) works by blocking the release of prostaglandins, which are known to induce pain and inflammation. Specifically, diclofenac inhibits cyclooxygenase (COX) activity, which ordinarily facilitates the conversion of arachidonic acid to prostaglandin H2, a precursor to prostaglandins and thromboxanes. Interestingly, diclofenac selectively inhibits COX-2, an enzyme that synthesizes prostaglandins, a mechanism that provides effective pain relief and alleviation of inflammation without oral administration.

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Nonsteroidal Anti-inflammatory Drug (NSAID)

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Gel

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Unveiling its multifaceted uses and transformative applications as follows:

• Diclofenac Diethylamine 1% is primarily used to reduce inflammation and pain associated with osteoarthritis and also for relieving menstrual cramps (dysmenorrhea).
• This medication is known as a nonsteroidal anti-inflammatory drug (NSAID) which helps reduce inflammation/swelling, pain, and fever.

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Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• For pain and swelling, apply the gel to the affected area 2-3 times a day.
• For muscle pain and sprains, initially apply 2 inches (5cm) gel to the affected area and rub in gently until it is absorbed into the skin, repeating this 3-4 times a day.
• For osteoarthritis, apply 2 inches (5cm) of gel to the affected area and rub in gently until it is absorbed into the skin, repeating this 3-4 times per day, with a maximum of 16g per day per adult.
• For migraine, follow the instructions that come with the medication as the dose will depend on the type of migraine medication you take. For example, if you are using a diclofenac nasal spray, you should spray once into each nostril. If you are using a dermal patch, you should apply the patch to the skin and keep it in place for up to 10 hours.
• For diabetic neuropathy, apply the gel topically to the affected area as directed by a doctor.
• For eye inflammation, dilute the diclofenac and apply it to the skin adjacent to the inner corner of the eye, nearest to the bridge of the nose, preferably with a half drop on the tip of a clean finger to massage into the skin. Do not apply directly to the eyes.
• Always follow the specific dosage instructions provided with your medication. If you have any questions or concerns, consult your doctor.

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An overdose of Diclofenac Diethylamine 1% should be treated as a medical emergency and requires immediate medical attention. If an overdose is suspected, it is vital to contact your local emergency services or find your nearest emergency room to receive proper treatment. In order to ensure appropriate and timely treatment, it is important to provide as much information as possible to the medical staff. This includes information about the medication involved, the approximate dose taken, and any other substances or medications that may have been consumed.Overdose victims should not attempt self-medication or home remedies due to the variety of symptoms that may arise and the potential for serious complications. Seeking immediate professional treatment significantly increases the chances of a successful outcome. Therefore, do not hesitate to reach out to emergency services if you suspect an overdose of Diclofenac Diethylamine 1%.

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If you miss a dose of Diclofenac Diethylamine 1%, it is important to take it as soon as possible. However, if it is almost time for your next dose, it is recommended to skip the missed dose and continue on your regular schedule. This is to avoid doubling up on doses, which could lead to an increased risk of experiencing adverse effects. If you are unsure about what to do or concerned about missing a dose, it is best to consult with your doctor or pharmacist for guidance. They can provide personalized advice on how to get back on track with your treatment plan and ensure that you avoid any unwanted side effects or disruptions in your treatment. It is crucial to follow the instructions provided by your healthcare provider to ensure that the treatment remains effective and safe. If you have any further questions or concerns about missing a dose, please consult with your doctor or pharmacist.

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Before applying Diclofenac Diethylamine 1% (topical gel), it is crucial to understand how to use it safely and correctly. You should consult the medication guide and ask your healthcare provider any questions you might have. Ensure your skin is clean and dry before applying the gel, and avoid broken or damaged skin. Shaved skin should be given at least 30 minutes before applying the gel to prevent irritation. Use your fingers to massage the gel into the skin, spreading it evenly and gently. Avoid using more gel with the belief that it will provide faster or better relief. After applying the gel, wash your hands unless the gel is for hand use. Avoid touching sensitive areas like your eyes where the gel has been. Use the gel regularly to get optimal results. If you have any concerns or questions about using the gel, discuss them with your doctor or pharmacist, especially if you have medical conditions or take other medications. If skin irritation occurs, stop using the gel and consult your doctor. In case of an overdose or allergic reaction, seek immediate medical attention. Following the provided instructions and completing the full course of treatment as directed by your doctor will provide the best possible outcome.

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Discerning instances where this medication may not be appropriate:

• You are allergic to diclofenac or any other NSAIDs (such as ibuprofen or naproxen).
• You have experienced asthma, hives, or other allergic reactions to any NSAID in the past.
• You have a history of bleeding ulcers or other serious stomach problems.
• You have a history of heart attack, stroke, or other heart-related conditions.
• You have severe kidney disease or kidney failure.
• You have liver disease or impaired liver function.
• You have a history of alcohol abuse.
• You are taking other medications that may interact with diclofenac, including blood thinners, antibiotics, antidepressants, or oral diabetes medication.

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Unraveling the side effects lurking behind this medications are as follows:

• Topical application of Diclofenac Diethylamine 1% may cause itching, burning, or stinging at the site in some patients.
• Other less common side effects include dryness, peeling, bruising, tingling, itching, or sweating.
• In rare cases, there is a risk of an allergic reaction with symptoms including hives, swelling of lips, face, throat, or tongue, difficulty breathing, and nausea and vomiting.
• Excessive use may lead to systemic effects such as diarrhea, dizziness, headache, nausea, vomiting, and heartburn.

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Precautions and Warnings for Patients:

• Patients with current or risk factors for cardiovascular disease (e.g., hypertension, hyperlipidaemia, diabetes mellitus, oedema, heart failure [NYHA-I], smoking)
• Patients with ulcerative colitis or Crohn’s disease
• Patients with coagulopathy, coagulation disorders, haematological abnormalities, or hypovolaemia
• Patients with systemic lupus erythematosus (SLE), mixed connective tissue disorders, or porphyria
• Patients with asthma, seasonal allergic rhinitis, or swelling of the nasal mucosa (e.g., nasal polyps)
• Patients with chronic obstructive pulmonary disease (COPD) or chronic respiratory tract infections
• Patients with coronavirus disease 2019 (COVID-19)
• Patients undergoing complicated ocular surgeries, repeat ocular surgeries within a short timeframe, corneal denervation, corneal epithelial defects, or other ocular surface diseases
• Debilitated or dehydrated patients
• Not indicated for migraine prophylaxis (oral use)
• Different diclofenac oral formulations are not bioequivalent or interchangeable
• Patients with mild to moderate renal and hepatic impairment
• Children and elderly patients
• Pregnancy (1st-2nd trimester) and lactation

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Drug interactions with diclofenac include:

• Anticoagulants (e.g., warfarin) (may increase the risk of bleeding- monitor INR closely)
• Other NSAIDs (e.g., ibuprofen) (may increase the risk of gastrointestinal bleeding and ulceration)
• Antihypertensives (e.g., ACE inhibitors, diuretics) (may reduce the effectiveness of blood pressure-lowering medications)
• Corticosteroids (e.g., prednisone) (may increase the risk of gastrointestinal adverse effects)
• Lithium (may increase lithium levels and risk of toxicity- monitor serum levels)
• Methotrexate (may increase the toxicity of methotrexate- monitor for adverse effects)
• CYP2C9 inhibitors (e.g., fluconazole) (may increase diclofenac levels and risk of side effects)
• Cyclosporine (may increase the risk of renal toxicity)
• Antidiabetic agents (e.g., metformin) (no significant interaction but monitor for any changes in blood glucose)

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Store diclofenac diethylamine at room temperature, away from moisture, heat, and direct light. Keep it in its original packaging, tightly sealed, and out of reach of children and pets. Avoid storing it in the bathroom. For disposal, do not flush diclofenac diethylamine down the toilet or pour it into drains unless instructed. Follow local disposal guidelines or use a drug take-back program to safely discard any unused or expired product, preventing accidental exposure or environmental harm.

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