Vonozan (10mg) 14 Tablets

Vonoprazan 10mg Tablet is a potassium-competitive acid blocker that suppresses gastric acid secretion. It works by inhibiting the potassium ion (K+) exchange mechanism in the gastric H+/K+-ATPase (proton pump), which is the final step in gastric acid secretion. Unlike proton pump inhibitors (PPIs), vonoprazan does not require acid for activation and can bind to the proton pump in a reversible manner, providing rapid and potent inhibition of gastric acid secretion. This mechanism of action allows vonoprazan to offer quick relief and maintain gastric pH at a higher level for an extended period, promoting healing and reducing symptoms associated with acid-related conditions.

Potassium-competitive acid blocker.

Tablet

The following are the uses of Vonoprazan 10mg Tablet:

• Used for treating gastroesophageal reflux disease (GERD) by reducing stomach acid production.
• Used to heal and prevent stomach ulcers, including those caused by nonsteroidal anti-inflammatory drugs (NSAIDs).
• Used for managing conditions like Zollinger-Ellison syndrome, where excessive acid is produced.
• Used to eradicate Helicobacter pylori (H. pylori) bacteria in the stomach, often in combination with antibiotics.
• Used to reduce the risk of upper gastrointestinal bleeding in patients with a history of bleeding or those at high risk.
• Used to improve symptoms of acid reflux, heartburn, and indigestion.
• Used as a long-term maintenance therapy to prevent the recurrence of acid-related conditions.

Follow these dosage instructions or as prescribed by your doctor:

• Gastric & Duedonal Ulcer

20mg daily administered orally for 8 weeks in case of gastric ulcer and 6 weeks for duodenal ulcer.

• Reflux esophagitis

20mg daily administered orally for 4 weeks

• Prevention of the Recurrence of Ulcer

10mg daily administered orally.

In the case of an overdose of Vonoprazan 10mg Tablets, it is important to remain calm and take appropriate actions. If a person ingests an excessive amount, they may experience symptoms such as dizziness, headache, or gastrointestinal discomfort. In such situations, immediate contact with a healthcare professional or poison control center is advised. They will provide guidance on the necessary steps, which may include monitoring, supportive care, or specific medical interventions to manage any adverse effects. Prompt action can help ensure the best possible outcome.

In the case of a missed dose of Vonoprazan 10mg Tablet, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, consult your healthcare provider for advice on how to adjust your dosing schedule and ensure the medication's effectiveness. It's important to maintain consistency with this medication for optimal results.

To take Vonoprazan 10mg Tablet, swallow the tablet whole with a glass of water, preferably in the morning before a meal, as directed by your healthcare provider, ensuring not to break or chew the tablet.

Here are the conditions or situations when Vonoprazan 10mg Tablet should not be used:

• Not recommended for individuals with a known hypersensitivity or allergy to Vonoprazan or other proton pump inhibitors (PPIs).
• Should not be used in patients with severe liver impairment or active liver disease.
• Contraindicated in individuals with a history of severe skin reactions to PPIs, such as Stevens-Johnson syndrome or toxic epidermal necrolysis.
• Not suitable for the treatment of gastroesophageal reflux disease (GERD) for longer than 8 weeks, unless directed by a healthcare professional.
• Should be avoided in patients with low magnesium levels or conditions that may cause low magnesium, as long-term use may lead to hypomagnesemia.
• Not recommended for individuals with Zollinger-Ellison syndrome or other conditions causing excessive stomach acid production.
• Discontinue use and seek medical attention if signs of an allergic reaction occur, such as rash, itching, swelling, or difficulty breathing.
• Do not use in patients with a history of systemic lupus erythematosus (SLE) as PPIs may exacerbate the condition.
• Not suitable for children or adolescents, as the safety and efficacy in this age group have not been established.
• Should not be used as a substitute for medical treatment of underlying conditions causing acid-related disorders.

The side effects of Vonoprazan 10mg Tablet may include:

• Diarrhea
• Headache
• Dizziness
• Abdominal pain
• Nausea
• Increased liver enzymes
• Skin rashes
• Fatigue

Following are the precautions and warnings for Vonoprazan 10mg Tablet:

• Patients with liver disease or impaired liver function should use this medication with caution as it is primarily metabolized in the liver. Regular monitoring of liver function may be necessary.
• Vonoprazan may increase the risk of gastrointestinal infections due to reduced stomach acidity. Patients should report any signs of infection, such as fever, persistent diarrhea, or abdominal pain.
• Long-term use of proton pump inhibitors like Vonoprazan may lead to vitamin B12 deficiency. Monitoring of vitamin B12 levels is recommended, especially in patients with risk factors.
• This medication may mask the symptoms of other gastrointestinal conditions such as stomach cancer. If symptoms persist or worsen, further medical evaluation is necessary.
• Elderly patients may be more susceptible to certain side effects, including bone fractures and Clostridium difficile-associated diarrhea. Close monitoring is advised.
• Patients should inform their healthcare provider of all medications they are taking, especially those that may interact with Vonoprazan, such as warfarin, diazepam, and phenytoin.
• Vonoprazan may cause hypomagnesemia (low magnesium levels). Healthcare providers should monitor magnesium levels and consider magnesium supplementation if necessary.
• Patients with a history of allergies or hypersensitivity reactions should disclose this information to their healthcare provider before taking Vonoprazan.

Following are the drug interactions for Vonoprazan 10mg Tablet:

• Concomitant use with Clopidogrel may reduce the effectiveness of Clopidogrel, a blood thinner, as Vonoprazan can decrease its absorption.
• The effects of anticoagulants like Warfarin may be enhanced, requiring close monitoring of blood clotting parameters.
• Vonoprazan can decrease the absorption of certain antifungal medications like Ketoconazole and Itraconazole, potentially reducing their effectiveness.
• Drugs metabolized by the liver's CYP3A4 enzyme, such as Cyclosporine and Tacrolimus, may have increased blood levels when used with Vonoprazan.
• It may interact with Diazepam, enhancing its sedative effects and potentially causing excessive drowsiness.
• The absorption of some antibiotics like Erythromycin can be affected, possibly reducing their efficacy.
• Caution is advised when using Vonoprazan with other medications that prolong QT interval, as it may increase the risk of abnormal heart rhythms.

Following are the food interactions to consider with Vonoprazan 10mg Tablet:

• Avoid grapefruit and grapefruit juice, as they can significantly increase the levels of Vonoprazan in the body by inhibiting the enzyme CYP3A4, leading to potential adverse effects.
• Alcohol consumption should be minimized or avoided as it can increase the risk of certain side effects, particularly liver-related issues.
• High-fat meals may slightly delay the absorption of Vonoprazan, but this effect is generally not clinically significant.
• Avoid excessive caffeine intake as it can increase stomach acid production, potentially reducing the medication's effectiveness.
• Spicy foods may irritate the digestive tract and exacerbate symptoms, especially during the healing process.
• Consuming a balanced diet rich in vitamins and minerals is essential to support overall health and the healing process.
• Certain foods like dairy, gluten, or specific allergens may trigger individual sensitivities, so it's advisable to be mindful of personal dietary restrictions.
• Ensure adequate hydration by drinking plenty of water throughout the day to support digestive health.

Vonoprazan 10mg Tablets should be stored in a cool and dry place, preferably in their original container, away from direct sunlight, moisture, and heat. The medication should be kept at room temperature, avoiding exposure to extreme temperatures. It is crucial to keep the tablets out of the reach of children and pets to prevent accidental ingestion. Ensure the container is tightly sealed to maintain its integrity. Always check the expiration date before use and dispose of any unused or expired tablets responsibly. Do not dispose of them in household waste or pour them down the drain; consult your pharmacist or local waste management guidelines for safe disposal practices.

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Following are the quick tips for Vonoprazan 10mg Tablet:

• Take the tablet as directed by your doctor, typically once daily.
• Swallow the tablet whole with a glass of water, preferably before a meal.
• Do not crush, chew, or break the tablet, as it may affect its effectiveness.
• Maintain a consistent daily routine for taking the medication.
• Avoid missing doses; if you miss one, take it as soon as you remember, unless it's almost time for the next dose.
• Inform your doctor if you have any liver or kidney issues before taking this medication.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.