Vorti (5mg) 14 Tablets

Vortioxetine's mechanism of action is multifaceted. It primarily acts as a serotonin modulator, influencing various serotonin receptors in the brain. Vortioxetine is a serotonin reuptake inhibitor, meaning it blocks the reabsorption of serotonin in the synaptic cleft, increasing its availability. Additionally, it acts as a serotonin agonist at certain receptors, stimulating serotonin activity, and as an antagonist at other receptors, modulating serotonin transmission. This unique profile enhances serotonin signaling in underactive serotonergic pathways while dampening it in overactive ones. Vortioxetine also indirectly affects other neurotransmitter systems, including noradrenaline, dopamine, and acetylcholine, contributing to its overall antidepressant and anxiolytic effects.

Serotonin modulator.

Tablet

The following are the uses of Vortioxetine 5mg Tablet:

• Used for treating major depressive disorder in adults.
• Used to improve mood, energy levels, and overall well-being.
• Used to enhance cognitive function, including memory and concentration.
• Used to reduce anxiety and promote emotional stability.
• Used to restore the balance of certain chemicals in the brain.
• Used to help individuals feel more motivated and engaged in daily activities.
• Used to manage symptoms such as sadness, loss of interest, and fatigue.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• For the treatment of major depressive disorder (MDD) or depressive episodes associated with bipolar disorder (BD)- Initially, 10 mg once daily for 1 week, followed by 20 mg once daily.
• The maximum dose is 20 mg once daily; increasing the dose above 20 mg does not appear to confer additional clinical benefits.
• Vortioxetine should be taken consistently, preferably at the same time each day, with or without food.

In the case of an overdose of Vortioxetine 5mg Tablets, individuals may experience an exacerbation of the drug's side effects. Symptoms can include severe nausea, vomiting, and increased heart rate. Additionally, there may be heightened nervous system effects, such as agitation, restlessness, and confusion. Prompt medical intervention is necessary to manage these symptoms and prevent potential complications, emphasizing the importance of seeking professional advice when an overdose is suspected.

In the case of a missed dose of Vortioxetine 5mg Tablet, it is recommended to take the missed dose as soon as you remember. However, if it is close to the time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, consult your healthcare professional for guidance on how to safely adjust your medication schedule. It is important to maintain a consistent routine when taking this medication for optimal effectiveness.

To take Vortioxetine 5mg Tablet, swallow the tablet whole with a full glass of water, preferably in the morning or as directed by your healthcare professional, without crushing or chewing the tablet.

Following are the conditions/situations when Vortioxetine 5mg Tablet should not be taken:

• Should not be used in individuals with a known hypersensitivity or allergy to Vortioxetine or any of its excipients.
• Contraindicated in individuals who are currently taking Monoamine Oxidase Inhibitors (MAOIs) or have taken MAOIs within the last 21 days.
• Not recommended for patients with a history of angle-closure glaucoma.
• Should not be used in patients with uncontrolled epilepsy or seizures.
• Contraindicated in individuals with congenital long QT syndrome or other conditions that may prolong the QT interval.
• Not suitable for individuals with severe liver impairment.
• Should be avoided in patients with a history of bleeding disorders or conditions that increase the risk of bleeding.
• Not recommended for individuals with a history of drug abuse or suicidal attempts.

The side effects of Vortioxetine 5mg Tablet may include:

• Nausea and vomiting
• Diarrhea
• Dry mouth
• Constipation
• Dizziness or lightheadedness
• Headache
• Increased sweating
• Insomnia or sleep disturbances

Following are the precautions and warnings for Vortioxetine 5mg Tablet:

• Not recommended for individuals with a known hypersensitivity or allergy to Vortioxetine or any of its ingredients.
• Patients with a history of liver or kidney disease should exercise caution, as this medication may require dosage adjustments under medical supervision.
• Vortioxetine may increase the risk of bleeding, especially in patients taking anticoagulants or with a history of bleeding disorders. Close monitoring is advised.
• Suicidal thoughts or behavior may emerge, particularly in young adults and children. Regular monitoring and immediate medical attention are crucial if such symptoms occur.
• This medication can cause drowsiness and blurred vision. Patients should avoid driving, operating heavy machinery, or engaging in activities requiring mental alertness until they know how the medication affects them.
• Vortioxetine may affect blood sugar levels. Patients with diabetes should monitor their blood sugar regularly and consult their doctor for any adjustments in diabetes medications.
• Elderly patients may be more sensitive to the side effects of Vortioxetine, especially those related to bleeding and central nervous system effects.
• Women who are pregnant or breastfeeding should consult their healthcare provider before taking Vortioxetine, as the risks and benefits should be carefully considered.

Following are the drug interactions for Vortioxetine 5mg Tablet:

• Avoid combining with other antidepressants like SSRIs or SNRIs, as it may lead to serotonin syndrome, a serious condition.
• Concomitant use with monoamine oxidase inhibitors (MAOIs) is contraindicated due to the risk of severe reactions.
• Vortioxetine may increase the anticoagulant effect of warfarin, requiring close monitoring.
• It can enhance the effects of central nervous system depressants like benzodiazepines and alcohol, leading to increased sedation.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) may elevate the risk of bleeding when taken simultaneously.
• Vortioxetine can impact the metabolism of certain medications, including anticonvulsants and antipsychotics, potentially raising their blood levels.
• Use with caution when combined with drugs affecting liver enzymes, as it may alter Vortioxetine's metabolism.

Following are the food interactions for Vortioxetine 5mg Tablet:

• Alcohol consumption should be limited or avoided as it can increase the risk of side effects and may interfere with the effectiveness of Vortioxetine.
• Grapefruit and grapefruit juice should be avoided as they can affect the metabolism of Vortioxetine, potentially increasing its levels in the body and leading to more side effects.
• Foods high in tyramine, such as aged cheeses, cured meats, and fermented foods, should be avoided. Vortioxetine may interact with tyramine, causing a sudden increase in blood pressure.
• Avoid eating large meals high in fat as they can slow down the absorption of Vortioxetine, potentially affecting its effectiveness.
• Maintain a consistent intake of Vitamin K-rich foods like leafy greens, as Vortioxetine may interfere with blood clotting.
• Limit the consumption of caffeine-containing beverages, as Vortioxetine may enhance its effects, leading to increased anxiety or insomnia.
• Stay hydrated and drink plenty of water, as Vortioxetine may cause dry mouth.
• Follow the dietary advice provided by your healthcare provider, especially if you have any specific dietary restrictions or conditions.

Vortioxetine 5mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area, ensuring they are out of reach of children and pets. Maintain a consistent room temperature, avoiding exposure to direct sunlight, excessive heat, or moisture to prevent degradation. It is crucial to keep the tablets in their original packaging, as this provides vital information and ensures their integrity. Disposal of Vortioxetine tablets should be done responsibly; do not flush them down the toilet or discard them in household waste. Instead, contact your local pharmacy or healthcare provider for guidance on proper medication disposal programs or designated collection sites, ensuring environmental safety and compliance with regulations. By following these storage and disposal practices, you can maintain the effectiveness of the medication and contribute to the well-being of your community.

Following are the quick tips for Vortioxetine 5mg Tablet:

• Start with the lowest effective dose and gradually increase if needed, as directed by your doctor.
• Take the tablet at the same time each day to maintain consistent levels in your body.
• Swallow the tablet whole with a full glass of water; do not crush, chew, or break it.
• Take the medication regularly to maximize its benefits; do not skip doses.
• If you experience side effects like nausea, try taking the tablet with food.
• Avoid alcohol consumption as it may interact with the medication.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.

When taking Vortioxetine, a prescription drug used to treat major depressive disorder (MDD), it is crucial to inform your doctor about all your medical conditions, allergies, and medications (including herbs and supplements) you are currently taking to ensure your safety. Laboratory tests are often required to ensure the medication is suitable for you and to monitor for adverse effects. These tests may include blood tests to check levels of sodium, potassium, and creatine, as well as kidney and liver function tests to monitor how Vortioxetine, which is eliminated from the body by the liver and excreted by the kidneys, is affecting these organs. An Electrocardiogram (ECG) may also be prescribed to monitor the heart's electrical activity, ensuring the medicine is not causing unwanted effects on the heart rate or rhythm and assessing for any possible cardiac conditions. Furthermore, thyroid function tests are important to assess the gland's functioning as Vortioxetine may interfere with it, and subsequent adjustments in dosage may be required to avoid any impact on your overall health. Although this list is not exhaustive, as your doctor may require additional tests, it is important to consult a medical professional for an accurate and complete laboratory testing list specific to your case, which may also be influenced by factors such as concurrent diseases, other medications taken, and personal medical history.