Votum (10mg) 28 Tablets

Olmesartan medoxomil, the active ingredient in the 10mg tablet, acts as a potent angiotensin II receptor blocker (ARB). Its mechanism of action involves selectively blocking the binding of angiotensin II to its receptors, specifically the AT1 receptors, which are found in various tissues such as vascular smooth muscle and the adrenal glands. By blocking the action of angiotensin II, a key hormone in the renin-angiotensin-aldosterone system (RAAS), olmesartan medoxomil inhibits the potent vasoconstrictive and aldosterone-secreting effects of angiotensin II. This leads to vasodilation, reduced vascular resistance, and ultimately a decrease in blood pressure. The medication's action results in relaxation of the blood vessels, allowing for improved blood flow and reduced strain on the heart, which contributes to its therapeutic effects in managing hypertension.

Angiotensin II receptor blocker

Tablet

The following are the uses of Olmesartan Medoxomil 10mg Tablet:

• Used for treating high blood pressure (hypertension)
• Used to lower blood pressure and reduce the risk of stroke, heart attack, and kidney problems
• Used in patients with diabetes and kidney disease to slow the progression of kidney damage
• Used to improve blood flow and reduce strain on the heart
• Used to manage hypertension in patients who have not responded well to other medications
• Used as a long-term treatment option to maintain healthy blood pressure levels
• Used for preventing hypertension-related complications, such as heart and blood vessel problems
• Used to improve overall cardiovascular health and quality of life in hypertensive patients

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Hypertension- The usual dose is 20-40 mg once daily. The dose may be increased to achieve a satisfactory blood pressure response after one week. In some patients, a lower starting dose of 10 mg once daily may be appropriate.
• Heart failure (reduced ejection fraction)- The usual starting dose is 20-40 mg once daily. It can be further increased to a maximum of 80 mg once daily if necessary to achieve the desired blood pressure reduction.
• Heart failure (preserved ejection fraction)- The recommended starting dose is 40 mg once daily. Just like in hypertension, if necessary, it can be increased to a maximum of 80 mg once day to achieve the desired blood pressure reduction.
• Kidney disease- For patients with mild to moderate kidney disease, the recommended starting dose is 20 mg once daily. It can be increased to 40 mg once daily if blood pressure is not adequately controlled. In severe kidney disease, olmesartan is not recommended.

In the case of an overdose of Olmesartan Medoxomil 10mg Tablets, it is important to recognize the signs and symptoms, which may include severe dizziness, fainting, and an irregular heartbeat. If you suspect an overdose, seek medical advice promptly. Treatment may involve monitoring vital signs, providing supportive care, and potentially administering medications to counteract the effects of the overdose. It is crucial to act quickly and not delay seeking medical assistance.

In the case of a missed dose of Olmesartan Medoxomil 10mg Tablet, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. It is important to maintain a consistent daily routine when taking this medication, but if you frequently miss doses, inform your healthcare provider for advice on how to improve adherence and ensure the medication's effectiveness.

To take Olmesartan Medoxomil 10mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Following are the conditions/situations when Olmesartan Medoxomil 10mg Tablet should not be taken:

• Should not be used in individuals with a known allergy or hypersensitivity to Olmesartan Medoxomil or any other angiotensin II receptor blockers (ARBs).
• Contraindicated in patients with severe liver disease, as it may lead to increased drug concentration and potential liver-related complications.
• Not recommended for individuals with severe kidney disease or those on dialysis, as dosage adjustments are necessary to prevent drug accumulation.
• Should not be used during pregnancy, especially in the second and third trimesters, as it may cause harm to the fetus.
• Contraindicated in patients with a history of intestinal angioedema or swelling of the intestines.
• Not suitable for individuals with a condition called bilateral renal artery stenosis, which affects blood flow to the kidneys.
• Should be discontinued if severe diarrhea or vomiting occurs, as it may lead to dehydration and potential kidney problems.

The side effects of Olmesartan Medoxomil 10mg Tablet may include:

• Dizziness
• Fatigue or tiredness
• Nausea and vomiting
• Diarrhea
• Muscle cramps
• Chest pain
• High potassium levels (hyperkalemia)
• Abnormal liver function tests

Following are the precautions and warnings for Olmesartan Medoxomil 10mg Tablet:

• This medication is not recommended for patients with severe liver disease or biliary obstruction, as it may lead to increased levels of olmesartan in the body.
• Patients with a history of angioedema (swelling of the face, lips, tongue, or throat) should not use this medication as it can cause a recurrence of this condition.
• Olmesartan can cause dizziness and lightheadedness, especially when standing up from a sitting or lying position. Elderly patients should exercise caution to avoid falls or accidents.
• Patients with a history of heart or kidney disease should have regular check-ups while taking this medication, as it can affect kidney function and electrolyte levels.
• It may cause fetal harm during pregnancy, especially in the second and third trimesters. Pregnant women should only use this medication if the potential benefit justifies the potential risk to the fetus.
• Breastfeeding women should exercise caution as olmesartan can pass into breast milk and may have adverse effects on the nursing infant.
• Patients should not use potassium supplements or salt substitutes containing potassium without medical advice, as Olmesartan can increase potassium levels in the blood.
• This medication may not be suitable for individuals with a history of severe diarrhea or vomiting, as it can lead to excessive loss of body water and electrolytes.

Following are the drug interactions for Olmesartan Medoxomil 10mg Tablet:

• Olmesartan can increase the levels of diuretics like hydrochlorothiazide, leading to enhanced blood pressure reduction.
• The effectiveness of anti-hypertensive drugs, such as beta-blockers, may be increased, requiring close monitoring.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) might reduce the blood pressure-lowering effect of Olmesartan.
• Drugs affecting the renin-angiotensin system, including ACE inhibitors, may lead to impaired kidney function when used with Olmesartan.
• When combined with lithium, Olmesartan may increase lithium levels, requiring close monitoring.
• Olmesartan may elevate potassium levels, especially when used with potassium-sparing diuretics or potassium supplements.
• Caution is advised with the use of certain anesthetics, as Olmesartan may interact and cause severe hypotension during surgery.

Following are the food interactions for Olmesartan Medoxomil 10mg Tablet:

• Avoid high-sodium foods and processed items like canned soups, chips, and fast food. Olmesartan may be less effective in lowering blood pressure if sodium intake is excessive.
• Limit alcohol consumption as it may increase side effects like dizziness and lightheadedness, especially when combined with the medication's blood pressure-lowering effects.
• Potassium-rich foods like bananas, oranges, and spinach should be consumed moderately. Olmesartan can increase potassium levels, and excessive intake might lead to hyperkalemia.
• Grapefruit and grapefruit juice should be avoided as they can interfere with the metabolism of Olmesartan, potentially increasing its blood levels and the risk of side effects.
• Maintain a balanced diet low in saturated fats and cholesterol. Olmesartan may be more effective when combined with a healthy diet in managing cardiovascular health.
• Avoid excessive use of herbal supplements, especially those affecting blood pressure, like licorice root, as they may interact with Olmesartan's mechanism of action.
• Caffeine intake should be monitored, as it might impact blood pressure and potentially interact with the medication's effects.
• Always stay hydrated by drinking adequate water, as dehydration can affect blood pressure and kidney function.

Olmesartan Medoxomil 10mg Tablets should be stored in a secure and dry location, preferably in their original container, at room temperature (68°F to 77°F or 20°C to 25°C). Protect the tablets from excessive heat, moisture, and direct sunlight, as these conditions can degrade the medication. It is crucial not to store them in the bathroom or any other humid environment. Always check the expiration date, and if the tablets are past their expiration, do not use them and dispose of them properly. For safe disposal, consult a pharmacist or healthcare professional for guidance, as improper disposal methods like flushing down the toilet or throwing them into the trash can pose risks to the environment. Keep the medication out of the sight and reach of children and pets to prevent accidental consumption.

Following are the quick tips for Olmesartan Medoxomil 10mg Tablet:

• Take the tablet as directed by your doctor, usually once daily.
• Consume the tablet with a glass of water, preferably at the same time each day.
• It can be taken with or without food, but taking it with food may reduce the risk of stomach upset.
• Avoid crushing or chewing the tablet; swallow it whole for effective absorption.
• If you forget a dose, take it as soon as you remember, unless it's nearly time for your next dose.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.
• Regularly monitor your blood pressure as advised by your doctor while taking this medication.

Olmesartan Medoxomil is a prescription drug that is used to treat high blood pressure. Like many other drugs in its class, it can cause kidney damage in certain situations. This is more likely to happen if the dose is too high or in people who already have problems with their kidneys. It is recommended that people taking Olmesartan Medoxomil have regular check-ups to monitor their kidney function. People who have preexisting liver disease may also experience higher blood pressures. Depending on individual health history, lab monitoring may be required. Your doctor will likely want to order some lab tests to check for side effects. These include a Complete Blood Count (CBC), a Comprehensive Metabolic Panel (CMP), a Lipid Panel, and a Blood Pressure Check. The CBC checks for problems with your blood cells, the CMP monitors the function of your kidneys and other organs, the Lipid Panel measures fat levels in your blood, and the Blood Pressure Check ensures that the drug is working properly. It is important to note that your doctor will tailor the lab tests to your specific needs based on your health history and any potential interactions with other medications you may be taking.