WARTEC CREAM 5G

Podophyllum cream, derived from the plant Podophyllum peltatum, exerts its therapeutic effects primarily through the activity of its active ingredient, podophyllotoxin. This compound acts as a potent antimitotic agent, meaning it disrupts the process of cell division. Specifically, podophyllotoxin binds to tubulin, a protein crucial for the formation of microtubules, which are essential components of the cell's internal structure. By inhibiting microtubule assembly, podophyllotoxin prevents the formation of the mitotic spindle, a structure required for chromosome segregation during cell division. This disruption leads to cell cycle arrest and ultimately cell death, making it effective against rapidly dividing cells, such as those found in certain skin conditions like genital warts.

Topical antineoplastic agent

Cream

The following are the uses of Podophyllum Cream:

• Used for treating genital warts caused by human papillomavirus (HPV).
• Used for removing external genital and perianal warts.
• Used for its ability to break down and eliminate abnormal wart cells.
• Used for its precision in targeting affected areas, reducing potential side effects.
• Used for its effectiveness in clearing warts, often within a few weeks of treatment.
• Used for reducing the risk of HPV transmission and associated complications.
• Used for its ease of application, allowing for self-administration under medical guidance.
• Used for its potential in preventing the recurrence of genital warts.

In the case of an overdose of Podophyllum Cream, individuals may experience severe gastrointestinal symptoms, including intense abdominal pain, nausea, and diarrhea. The active ingredient, podophyllotoxin, can lead to dehydration and electrolyte imbalances if consumed in excessive amounts. Timely intervention is crucial, involving immediate contact with a healthcare professional or poison control center. They will provide guidance on managing the symptoms and may recommend supportive care to alleviate the adverse effects of the overdose.

In the case of a missed dose of Podophyllum Cream, it is important to act promptly. If you remember within a few hours of the missed application, apply the cream as soon as possible. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not apply extra cream to make up for the missed dose, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or asking someone to help you stay on track with your treatment plan.

To apply Podophyllum Cream, clean and dry the affected area, then gently massage a thin layer of the cream onto the skin, ensuring complete coverage, and follow the prescribed dosage and application frequency as directed by your healthcare provider.

Following are the conditions/situations when Podophyllum Cream should not be used:

• Do not use if you have an allergy or sensitivity to any of the ingredients in the cream.
• Avoid using on broken skin, open wounds, or areas with active skin infections.
• Not suitable for individuals with a history of skin disorders or skin reactions to similar medications.
• Should not be used on the face or around the eyes.
• Contraindicated for children and elderly patients without medical supervision.
• Do not use on skin conditions like eczema, psoriasis, or severe skin irritation.
• Avoid using on genital warts or other genital conditions without medical advice.
• Do not use if you are pregnant or breastfeeding, unless advised by a healthcare professional.
• Discontinue use if skin irritation, redness, or severe burning occurs.

The side effects of Podophyllum Cream may include:

• Skin irritation at the application site
• Redness or rash
• Itching or burning sensation
• Skin peeling or dryness
• Increased sensitivity to sunlight
• Diarrhea (if accidentally ingested)
• Stomach pain or cramping (in rare cases)
• Allergic reactions (skin rash, swelling, difficulty breathing)

Following are the precautions and warnings for Podophyllum Cream:

• Do not use on broken or irritated skin; avoid contact with eyes, nose, and mouth.
• Wash hands thoroughly after application to avoid accidental exposure to other areas.
• It is for external use only and should not be ingested or applied to mucous membranes.
• Not recommended for use on children under 12 years of age without medical supervision.
• Do not use if you are pregnant or breastfeeding unless directed by a healthcare professional.
• Discontinue use and consult a doctor if skin irritation, redness, or any adverse reaction occurs.
• Keep out of reach of children and pets to prevent accidental ingestion.

Following are the drug interactions for Podophyllum Cream:

• It may interact with other topical agents containing podophyllotoxin, increasing the risk of local skin irritation and toxicity.
• Concomitant use with other irritant or abrasive skin products can exacerbate skin reactions.
• Podophyllum Cream should not be used with other medications that cause photosensitivity, as it may increase the risk of sunburn.
• Avoid using it with other treatments for genital warts, as this may lead to excessive skin reactions.
• The cream may increase the effects of certain immunosuppressant drugs, leading to potential immunosuppression.
• Use with caution when taking oral medications containing podophyllotoxin, as it may result in increased systemic exposure.
• Some herbal remedies or supplements applied topically might interact, causing skin sensitivity.

Following are the food interactions for Podophyllum Cream:

• Avoid consuming citrus fruits and their juices, especially grapefruit, as they may influence the absorption and increase the effects of the cream.
• Dairy products like milk, cheese, and yogurt can potentially interact with Podophyllum Cream, as they may contain calcium and other minerals that can affect the skin's response to the treatment.
• Alcohol should be avoided during the use of this cream, as it can cause increased skin sensitivity and dryness.
• Fatty foods high in oil and fat content might alter the absorption and effectiveness of the cream, potentially reducing its therapeutic effect.
• Spicy foods are known to cause skin flushing and irritation in some individuals, which may be exacerbated when using Podophyllum Cream.
• Caffeinated beverages like coffee and tea could potentially dehydrate the skin, affecting the overall efficacy of the cream.
• Certain vegetables like broccoli and cabbage, which are high in vitamins and minerals, might interact with the cream's active ingredients and alter their effects.
• Herbs and herbal supplements should be used with caution, as some may have skin-sensitizing properties that could enhance the effects of Podophyllum Cream.

Podophyllum Cream should be stored with care to ensure its effectiveness and safety. Keep the cream in a cool, dry place, preferably at room temperature, and protect it from direct sunlight and heat sources like ovens or radiators, as these can degrade the medication. Always keep the cream in its original container, tightly sealed, to maintain its integrity and prevent contamination. Check the expiration date regularly, and dispose of any expired or unused cream responsibly; do not flush it down the toilet or pour it into drainage systems. Consult your pharmacist for guidance on proper disposal methods. Keep the cream away from children to prevent accidental exposure.

Following are the quick tips for Podophyllum Cream:

• Apply a thin layer of the cream to the affected area as directed by your doctor.
• Wash your hands before and after application to maintain hygiene.
• Clean and dry the skin before applying the cream for better absorption.
• Use the cream as a part of your skincare routine consistently for best results.
• Avoid applying the cream on broken or irritated skin.
• Do not cover the treated area with bandages or tight clothing.
• Store the cream at room temperature, away from direct sunlight and moisture.