WELLCOSINE 120ML SYP

Doxycycline, a tetracycline antibiotic, exerts its mechanism of action by inhibiting bacterial protein synthesis. It primarily targets the 30S ribosomal subunit, binding to the 16S rRNA, which interferes with the binding of aminoacyl-tRNA to the ribosomal acceptor (A) site. This action prevents the addition of amino acids to the growing polypeptide chain, disrupting bacterial protein synthesis and ultimately leading to bacterial growth inhibition. Doxycycline is effective against a wide range of bacteria, including both gram-positive and gram-negative organisms, as well as some atypical bacteria.

Vitamin B, C and Lysine

Tetracycline antibiotic

Suspension

The following are the uses of Doxycycline 100mg Syrup/Suspension:

• Used for treating respiratory tract infections such as pneumonia and bronchitis.
• Used for controlling and reducing acne symptoms and severity.
• Used for managing certain sexually transmitted infections like chlamydia.
• Used for preventing and treating malaria, especially in regions with known drug-resistant strains.
• Used for treating and controlling bacterial infections in the urinary tract.
• Used for managing skin and soft tissue infections, including cellulitis and abscesses.
• Used for controlling bacterial infections in the gastrointestinal tract, such as those causing traveler's diarrhea.

In the case of an overdose of Doxycycline 100mg Syrup/Suspension, individuals may experience gastrointestinal symptoms such as nausea, vomiting, and diarrhea. They might also develop a sore throat, difficulty swallowing, and an unpleasant taste in the mouth. In more severe cases, an overdose can lead to kidney damage, liver problems, and an increased sensitivity to sunlight, resulting in severe sunburns. It is crucial to seek medical advice promptly if an overdose is suspected.

In the case of a missed dose of Doxycycline 100mg Syrup/Suspension, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely adjust your dosing schedule and ensure you receive the full course of treatment.

To use Doxycycline 100mg Syrup/Suspension, shake the bottle well, measure the prescribed dose with a measuring device like a dosing spoon, and take it orally once or twice a day as directed by your healthcare provider, ensuring you follow the dosage instructions and do not exceed the recommended amount.

Following are the conditions/situations when Doxycycline 100mg Syrup/Suspension should not be used:

• Should not be given to children below 8 years of age, as it may cause permanent tooth discoloration and affect bone development.
• Contraindicated in individuals with a known allergy or hypersensitivity to doxycycline, other tetracycline antibiotics, or any of the excipients in the syrup/suspension.
• Not recommended for individuals with severe liver impairment, as it may lead to increased drug toxicity.
• Avoid use in patients with severe kidney disease, as it can cause further deterioration of kidney function.
• Should not be used during pregnancy, especially during the second and third trimesters, as it can cause permanent tooth discoloration in the developing fetus.
• Contraindicated in breastfeeding mothers, as doxycycline passes into breast milk and can affect bone and tooth development in nursing infants.
• Avoid use in individuals with esophageal stricture or achalasia, as the medication may cause further difficulty in swallowing.
• Not suitable for patients with myasthenia gravis, as it may exacerbate muscle weakness.

The side effects of Doxycycline 100mg Syrup/Suspension may include:

• Nausea and vomiting
• Diarrhea
• Loss of appetite
• Skin reactions, such as rashes or increased sensitivity to sunlight
• Headache
• Dizziness
• Sore throat and oral thrush
• Vaginal itching or discharge

Here are the precautions and warnings for Doxycycline 100mg Syrup/Suspension:

• This medication should not be used in patients with a known allergy to doxycycline or other tetracycline antibiotics.
• May cause permanent tooth discoloration and enamel hypoplasia in children under 8 years old, pregnant women, and during the second and third trimesters of pregnancy. Avoid use in these populations.
• Avoid exposure to sunlight or artificial UV rays as it may cause photosensitivity reactions. Wear protective clothing and use sunscreen.
• May cause an increase in intracranial pressure, so patients with a history of intracranial hypertension should exercise caution and be monitored for any neurological symptoms.
• Doxycycline may decrease the effectiveness of birth control pills, so alternative contraceptive methods should be considered.
• Patients with liver impairment should use with caution as doxycycline is primarily metabolized in the liver.
• Discontinue use and consult a doctor if you experience severe diarrhea or allergic reactions.
• Keep out of reach of children. Store in a cool, dry place, away from direct sunlight.

Following are the drug interactions for Doxycycline 100mg Syrup/Suspension:

• Avoid concurrent use with antacids, calcium supplements, and dairy products, as they can reduce the absorption of doxycycline.
• Doxycycline may decrease the effectiveness of hormonal contraceptives, including birth control pills, patches, and rings. Consider alternative contraceptive methods.
• Taking doxycycline with iron supplements, multivitamins, or dairy products can reduce its absorption. Take doxycycline 2-3 hours before or after these products.
• The antibiotic effect of doxycycline can be reduced by penicillins, increasing the risk of treatment failure.
• Anticoagulants like warfarin may have their blood-thinning effect enhanced by doxycycline, requiring close monitoring of blood clotting time.
• Doxycycline may increase the blood levels of digoxin, a heart medication, leading to potential toxicity. Regular monitoring of digoxin levels is advised.
• The effectiveness of live bacterial vaccines, such as typhoid vaccine, may be reduced by doxycycline. Separate administration by at least 3 days.

Following are the food interactions for Doxycycline 100mg Syrup/Suspension:

• Avoid consuming dairy products like milk, yogurt, cheese, or calcium-fortified juices immediately after taking Doxycycline. These products can bind with the medication, reducing its absorption. Separate the medication and dairy intake by at least 2-3 hours.
• Avoid taking Doxycycline with foods rich in iron, zinc, magnesium, or aluminum, as these minerals can interfere with the absorption of the medication. This includes multivitamins and mineral supplements.
• Grapefruit juice should be avoided as it can decrease the breakdown of Doxycycline, leading to higher levels of the drug in the body and increasing the risk of side effects.
• Alcohol may decrease the effectiveness of Doxycycline and increase the risk of liver-related side effects. It is advisable to limit or avoid alcohol consumption during the treatment.
• Avoid taking Doxycycline with antacids containing aluminum, calcium, or magnesium, as these can decrease the absorption of the antibiotic.
• High-fat meals may slightly delay the absorption of Doxycycline, but this is generally not considered a significant interaction.
• Certain dairy-free alternatives like soy milk may also affect absorption, so it's best to consult your healthcare provider for suitable alternatives.

Doxycycline 100mg Syrup/Suspension should be stored in a secure and controlled environment, preferably in a cool and dry place, maintaining a consistent room temperature. Protect the medication from direct sunlight, heat, and moisture, as these can degrade its effectiveness. Keep the syrup in its original container, tightly sealed, to maintain its integrity and prevent contamination. It is crucial to adhere to the recommended storage conditions to ensure the medication's efficacy and safety. When disposing of unused or expired Doxycycline syrup, do not flush it down the toilet or pour it into drainage systems. Instead, consult your pharmacist or healthcare professional for appropriate disposal methods to minimize environmental impact. Additionally, ensure that the medication is stored out of children's reach to prevent accidental consumption, as it can be harmful if ingested without medical supervision.

Following are the quick tips for Doxycycline 100mg Syrup/Suspension:

• Consult a doctor or pharmacist for the right dosage and duration for your specific condition.
• Ensure you complete the full course as prescribed, even if you feel better.
• Shake the bottle vigorously before each use to ensure proper medication mixing.
• Administer the syrup with a measuring cup or oral syringe for accurate dosing.
• Take the medication with a full glass of water to aid in swallowing and absorption.
• Avoid lying down immediately after taking the syrup to prevent irritation.
• Store the medication at room temperature, away from sunlight and moisture.