WINGESIC PLUS IMP 200'S

Diclofenac, a non-steroidal anti-inflammatory drug (NSAID), primarily works by inhibiting cyclooxygenase (COX) enzymes, reducing the production of prostaglandins, which are key mediators of inflammation and pain. Paracetamol, also known as acetaminophen, exerts its analgesic and antipyretic effects by inhibiting the synthesis of prostaglandins in the central nervous system, although the exact mechanism is not fully understood. Chlorzoxazone, a muscle relaxant, acts centrally on the spinal cord and brainstem to reduce muscle spasm and pain, potentially by inhibiting the release of excitatory neurotransmitters and reducing muscle hyperactivity. When combined, these three components provide synergistic effects for managing pain, inflammation, and muscle stiffness.

1. Non-steroidal anti-inflammatory drug (NSAID) 2. Analgesic/Antipyretic 3. Muscle relaxant

Tablet

The following are the uses of Diclofenac, Paracetamol, Chlorzoxazone Tablet:

• Used for relieving pain and reducing inflammation
• Used for managing mild to moderate pain and fever
• Used to relax muscles and reduce muscle spasms
• Used for treating acute pain and inflammation after injuries or surgeries
• Used in conditions like back pain, muscle pain, and joint stiffness
• Used to provide short-term relief from painful conditions
• Used to improve mobility and flexibility in muscle-related issues
• Used to manage pain and discomfort in various musculoskeletal disorders

In the case of an overdose of Diclofenac, Paracetamol, and Chlorzoxazone Tablet, prompt medical intervention is necessary. Symptoms may include nausea, vomiting, abdominal pain, and potential liver damage. The severity of the effects can vary depending on the individual and the amount ingested. It is important to seek medical advice and treatment as soon as possible to manage the potential risks and complications associated with this specific combination of drug overdose.

In the case of a missed dose of Diclofenac, Paracetamol, and Chlorzoxazone Tablet, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. It is important not to double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare professional for advice on how to safely resume your medication regimen.

To take the Diclofenac, Paracetamol, and Chlorzoxazone Tablet, swallow the tablet whole with a full glass of water, preferably with or after a meal, exactly as prescribed by your healthcare professional, ensuring you follow the recommended dosage instructions provided.

Following are the conditions when Diclofenac, Paracetamol, Chlorzoxazone Tablet should not be used:

• Avoid if allergic to any of the components, especially Diclofenac, Paracetamol, or Chlorzoxazone.
• Not recommended for individuals with a history of gastrointestinal bleeding or perforation.
• Contraindicated in patients with severe heart failure or high risk of cardiovascular events.
• Should not be used in individuals with severe kidney or liver impairment.
• Not suitable for those who have had an asthma attack, hives, or other allergic reactions to non-steroidal anti-inflammatory drugs (NSAIDs).
• Avoid using this medication if you have a history of stomach ulcers or bleeding disorders.
• Do not take this medication if you are pregnant or breastfeeding without medical advice.

The side effects of Diclofenac, Paracetamol, and Chlorzoxazone Tablet may include:

• Stomach pain, nausea, or vomiting
• Headache or dizziness
• Drowsiness or fatigue
• Skin rash or itching
• Diarrhea or constipation
• Increased liver enzymes
• Allergic reactions (e.g., swelling of the face, lips, or throat, difficulty breathing)
• Increased risk of bleeding (in the case of Paracetamol)

Following are the precautions and warnings for Diclofenac, Paracetamol, and Chlorzoxazone Tablet:

• This medication should be used with caution in patients with a history of gastrointestinal problems as it may cause stomach bleeding or ulcers.
• Patients with cardiovascular risks such as high blood pressure, heart disease, or a history of stroke should exercise caution and consult a doctor before use, as this medication may increase the risk of heart-related problems.
• Not recommended for individuals with a known allergy to diclofenac, paracetamol, chlorzoxazone, or any other NSAIDs.
• It is advisable to avoid excessive alcohol consumption while taking this medication, as it may increase the risk of liver damage.
• Patients with kidney problems should use this medication with caution and under medical supervision, as it may affect kidney function.
• Not suitable for children and elderly patients without medical advice, as dosage adjustments may be necessary.
• Pregnant and breastfeeding women should consult a healthcare professional before taking this medication as it may have potential risks for the fetus and infant.

Following are the drug interactions for Diclofenac, Paracetamol, and Chlorzoxazone Tablet:

• Concurrent use with other non-steroidal anti-inflammatory drugs (NSAIDs) may increase the risk of gastrointestinal bleeding and kidney problems.
• Paracetamol can prolong the effects of anticoagulants like warfarin, requiring close monitoring of bleeding parameters.
• Chlorzoxazone may enhance the sedative effects of central nervous system depressants, such as benzodiazepines and opioids.
• The tablet may reduce the effectiveness of diuretics and antihypertensive medications, potentially raising blood pressure.
• Diclofenac can interact with certain antibiotics, such as quinolones and aminoglycosides, increasing their toxicity.
• It may also reduce the effectiveness of lithium, a medication used for bipolar disorder.
• Antacids containing aluminum or magnesium can decrease the absorption of Diclofenac.

Following are the food interactions for Diclofenac, Paracetamol, and Chlorzoxazone Tablet:

• Alcohol intake should be minimized or avoided as it can increase the risk of liver damage and stomach bleeding, especially with Diclofenac and Paracetamol.
• Grapefruit juice should be avoided as it may affect the metabolism of Diclofenac, potentially increasing its levels in the body.
• High-fat meals can delay the absorption of Diclofenac, potentially affecting its onset of action.
• Caffeine-containing beverages should be limited as they may increase the metabolism of Paracetamol, potentially reducing its effectiveness.
• Avoid consuming excessive amounts of foods high in tyramine (aged cheeses, cured meats) as Chlorzoxazone can interact with tyramine and increase blood pressure.
• Spicy foods may irritate the stomach and should be consumed in moderation, especially when taking Diclofenac, which can cause gastrointestinal issues.
• Foods rich in vitamin K (leafy greens) should be consumed consistently as Diclofenac may interfere with blood clotting.
• Maintain a balanced diet to support overall health and medication effectiveness, ensuring proper hydration and a healthy diet to aid in the body's response to the medication.

Diclofenac, Paracetamol, and Chlorzoxazone Tablets should be stored in a cool, dry place, preferably at room temperature, away from direct sunlight and moisture. The tablets should be kept in their original packaging, ensuring the container is tightly sealed to maintain their integrity. Avoid storing them in bathrooms or near heat sources like ovens or radiators, as temperature fluctuations can impact their effectiveness. It is crucial to adhere to the recommended storage conditions to preserve the medication's quality. Proper disposal is essential; do not discard them in wastewater or household garbage. Consult your pharmacist or local waste management guidelines for safe disposal practices, ensuring environmental responsibility. Keep this medication securely stored, out of children's reach, to prevent accidental consumption.

Following are the quick tips for Diclofenac, Paracetamol, Chlorzoxazone Tablet:

• Consult a doctor for a personalized dosage plan.
• Take the tablet with or after food to prevent stomach irritation.
• Ensure you drink enough water throughout the day.
• Avoid alcohol consumption as it may intensify side effects.
• Be cautious if driving or operating machinery, as it may cause dizziness.
• Inform your doctor about any existing medical conditions and medications.
• Store the tablets in a cool, dry place, away from direct sunlight.
• Do not share your medication with others, even with similar symptoms.