WINRHO INJ ANTI D

Rho(D) Immune Globulin Intravenous (Human) works by binding to and neutralizing Rh-positive red blood cells in individuals who are Rh-negative. It contains antibodies specific to the D antigen present on Rh-positive red blood cells. When administered, the antibodies in Rho(D) Immune Globulin quickly attach to any Rh-positive cells in the recipient's circulation, marking them for destruction by the immune system. This process helps prevent the sensitization of the Rh-negative individual's immune system, reducing the risk of a potentially dangerous immune response in future pregnancies or blood transfusions involving Rh-positive blood.

Anti-D immunoglobulin

Injection

The following are the uses of Rho(D) Immune Globulin Intravenous (Human) Intravenous or Intramuscular Injection [Standardized amount of Anti D antibody] Injection:

• Used for preventing Isoimmunization in Rh-negative women
• Used to treat immune thrombocytopenic purpura (ITP)
• Used for treating certain blood conditions in newborns
• Used to prevent Rh hemolytic disease of the newborn (HDN)
• Used for treating immune thrombocytopenia (ITP) in children and adults
• Used post-partum to prevent maternal Rh alloimmunization
• Used for treating or preventing bleeding in certain patients

In the case of an overdose of Rho(D) Immune Globulin Intravenous (Human) or Intramuscular Injection, the primary concern is the potential for an allergic reaction or anaphylaxis. Monitor for symptoms such as difficulty breathing, hives, or swelling. Seek medical advice promptly for any adverse reactions, as treatment may involve supportive care and managing symptoms until the effects of the overdose subside. Prompt medical assessment is essential to ensure appropriate management.

In the case of a missed dose of Rho(D) Immune Globulin Intravenous (Human) Injection, it is important to contact your healthcare provider as soon as possible. They will advise you on the appropriate course of action, which may involve administering the missed dose as soon as possible or adjusting the subsequent dosing schedule. Do not attempt to double the dose or self-administer the injection without medical guidance, as this could lead to potential risks and complications.

To administer Rho(D) Immune Globulin Intravenous (Human) Injection, reconstitute the medication as instructed, then inject the entire contents of the vial slowly, either through a sterile intravenous infusion or deep intramuscular injection, following proper aseptic techniques and guidelines for safe injection practices.

Following are the conditions or situations when Rho(D) Immune Globulin Intravenous (Human) should not be used:

• Do not use if the patient has a history of severe allergic reactions to human immune globulin products or any component of the formulation.
• Contraindicated in individuals with a history of anaphylaxis.
• Should not be administered to individuals with a known IgA deficiency, as they may develop anti-IgA antibodies and have severe hypersensitivity reactions.
• Not recommended for individuals with a history of thrombosis or thromboembolic disorders, as it may increase the risk of blood clots.
• Do not use in patients with severe thrombocytopenia, as it may further decrease platelet counts.
• Contraindicated in individuals with a history of hemolytic disease of the newborn (HDN) due to ABO or other blood group incompatibility, as it is not effective in these cases.
• Should not be used in patients with a history of severe systemic reactions to Rho(D) immune globulin products.
• Not recommended for individuals with severe renal impairment or kidney disease, as it may affect the clearance of the medication.

The side effects of Rho(D) Immune Globulin Intravenous (Human) Injection may include:

• Fever or chills
• Headache
• Nausea and vomiting
• Dizziness or lightheadedness
• Pain and swelling at the injection site
• Muscle or joint pain
• Fatigue
• Allergic reactions (such as rash, itching, or difficulty breathing)

Following are the precautions and warnings for Rho(D) Immune Globulin Intravenous (Human) Injection:

• Not suitable for individuals with a history of hypersensitivity or severe allergic reactions to human immune globulin or any of its components.
• Must be administered by trained healthcare professionals due to the risk of severe allergic reactions.
• Monitor patients closely for signs of anaphylaxis during and after injection, especially those with a history of allergies or asthma.
• Ensure proper dosage calculation based on patient weight to prevent potential overdose.
• Use with caution in patients with a history of thrombosis or thromboembolic disorders, as it may increase the risk of blood clots.
• Not recommended for intramuscular injection in patients with a history of bleeding disorders or those on anticoagulant therapy.
• Pregnant women should only use it if clearly needed and under medical supervision, as it can cross the placenta.
• Consult a healthcare professional if you have any underlying medical conditions before receiving this injection.

Following are the drug interactions for Rho(D) Immune Globulin Intravenous (Human) Intravenous or Intramuscular Injection:

• Concomitant use with live vaccines, such as measles, mumps, rubella, or varicella, may reduce the effectiveness of the vaccine. It is recommended to delay live vaccinations for at least 3 months after receiving Rho(D) Immune Globulin.
• Immunosuppressive drugs, such as corticosteroids or chemotherapy agents, may increase the risk of infection or reduce the immune response when used with Rho(D) Immune Globulin.
• Blood thinners, such as warfarin, may require more frequent monitoring of coagulation parameters, as the injection can affect platelet function.
• Other immunoglobulins, when administered concurrently, may increase the risk of excessive immune response or immune-related side effects.
• Rho(D) Immune Globulin may interfere with the results of certain blood tests, such as direct antiglobulin tests (DAT), which could cause false-positive results.
• Concomitant use with high-dose aspirin or other anticoagulants may increase the risk of bleeding complications, especially when administered via injection.

Following are the food interactions for Rho(D) Immune Globulin Intravenous (Human) Injection:

• No specific food interactions are known for this medication.
• Generally, it is safe to consume food and beverages as usual after receiving Rho(D) Immune Globulin.
• There is no evidence that any particular food or drink enhances or diminishes the effectiveness of the medication.
• It is recommended to maintain a normal, balanced diet to support overall health and well-being during treatment.
• Stay hydrated by drinking enough fluids, especially water, to support the body's immune response.
• Avoid excessive alcohol consumption as it may affect your body's ability to recover and could potentially interact with other medications.
• If you have specific dietary restrictions or concerns, consult your healthcare provider for personalized advice.
• No known food restrictions are associated with Rho(D) Immune Globulin Intravenous (Human) Injection.

Rho(D) Immune Globulin Intravenous (Human) should be stored in a controlled environment, preferably between 2°C and 25°C (36°F and 77°F), in its original packaging to maintain sterility. Protect the injection vials from light and do not freeze the medication. Once the vial is opened, any remaining solution should be discarded; do not store for future use. Dispose of all medical waste, including used vials and needles, in accordance with local regulations and guidelines. It is crucial to follow proper disposal methods to prevent environmental contamination and ensure the safety of others. Keep the medication out of the reach of children and pets to avoid accidental exposure.

Following are the quick tips for Rho(D) Immune Globulin Intravenous (Human) Injection:

• Ensure the injection is administered by a healthcare professional as prescribed.
• Verify the correct dosage and product before administration.
• Intravenous injection should be given slowly as directed.
• For intramuscular injection, choose a clean, dry site and rotate injection areas.
• Avoid touching the needle or exposing it to any surface to prevent contamination.
• Dispose of used needles and syringes safely in designated sharps containers.
• Report any adverse reactions or persistent side effects to your healthcare provider promptly.
• Store the product as directed on the package insert, away from light and moisture.