X-Plended EZ (20/10mg) 10 Tablets

Ezetimibe and Rosuvastatin work synergistically to lower cholesterol levels. Ezetimibe acts by inhibiting the absorption of cholesterol in the small intestine, primarily by targeting the Niemann-Pick C1-like 1 (NPC1L1) protein, which is responsible for cholesterol uptake. This inhibition leads to a reduction in the amount of cholesterol absorbed from food and bile. On the other hand, Rosuvastatin, a potent HMG-CoA reductase inhibitor, blocks the enzyme responsible for the conversion of HMG-CoA to mevalonate, a critical early step in cholesterol synthesis. By inhibiting this enzyme, Rosuvastatin significantly reduces the liver's production of cholesterol, resulting in lower levels of LDL cholesterol in the blood. The combined effect of Ezetimibe and Rosuvastatin is a more comprehensive approach to managing high cholesterol, as they target both cholesterol absorption and synthesis.

Ezetimibe 10mg, Rosuvastatin 20mg

Statin and cholesterol absorption inhibitor.

Tablet

The following are the uses of Ezetimibe 10mg, Rosuvastatin 20mg Tablet:

• Used for lowering high cholesterol and triglyceride levels in the blood.
• Used to treat conditions where cholesterol and fat levels are elevated, such as primary hyperlipidemia or mixed dyslipidemia.
• Used to slow the formation of fatty deposits in blood vessels, helping to prevent blockages and reduce the risk of cardiovascular events.
• Used to improve lipid profiles, specifically targeting LDL (bad) cholesterol and triglycerides.
• Used as an adjunct to diet and lifestyle changes to manage cholesterol and lipid levels effectively.
• Used to reduce the risk of heart attacks, strokes, and other cardiovascular complications in high-risk patients.
• Used for long-term management of cholesterol and lipid disorders, helping to maintain healthy levels over time.
• Used under the guidance of a healthcare professional who will monitor its effectiveness and adjust the dosage as needed.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• Cholesterol Level- Take 2 grams per day with dinner for cholesterol level less than 200.
• Weight Loss- Take 5 grams with breakfast, lunch, dinner and bedtime for weight loss.
• Diabetes- Take 5 grams with each meal to reduce hemoglobin A1C levels.
• Hyperlipidemia- Take 20 mg of Rosuvastatin and 10 mg of Ezetimibe with dinner to reduce cholesterol levels.

In the case of an overdose of Ezetimibe 10mg and Rosuvastatin 20mg tablets, individuals may experience symptoms such as abdominal pain, muscle aches, and increased liver enzymes. It is important to recognize that taking more than the prescribed dosage can lead to adverse effects. If an overdose is suspected, seeking medical advice promptly is recommended. Patients should contact their healthcare provider or local poison control center for guidance on managing potential complications and determining the appropriate course of action.

In the case of a missed dose of Ezetimibe 10mg, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. For Rosuvastatin 20mg, if you miss a dose, take it as soon as you remember, but if it's close to your next dose, skip the missed dose and resume your regular dosing. It's important to note that you should not double the dose to make up for a missed one, as this may increase the risk of side effects. Consult your healthcare provider if you frequently miss doses or have concerns about your medication schedule.

To take the Ezetimibe 10mg, Rosuvastatin 20mg Tablet, swallow one tablet whole with a glass of water, preferably at the same time each day, as directed by your healthcare provider.

Following are the conditions or situations when Ezetimibe 10mg, Rosuvastatin 20mg Tablet should not be taken:

• Should not be used in individuals with a known allergy to Ezetimibe, Rosuvastatin, or any other similar statin medications.
• Contraindicated in patients with active liver disease or persistent elevations in liver enzymes.
• Not recommended for individuals with uncontrolled hypothyroidism.
• Should not be used in patients with a history of muscle pain or weakness, or those who are at risk of developing rhabdomyolysis.
• Contraindicated during pregnancy or breastfeeding.
• Not suitable for individuals with a history of unexplained elevated creatine kinase (CK) levels.
• Should be avoided in patients with a history of alcohol abuse or heavy drinking.

The side effects of Ezetimibe 10mg, Rosuvastatin 20mg Tablet may include:

• Muscle pain and weakness
• Joint pain
• Nausea and vomiting
• Diarrhea
• Abdominal pain
• Increased liver enzymes
• Fatigue
• Headache

Following are the precautions and warnings for Ezetimibe 10mg, Rosuvastatin 20mg Tablet:

• Do not start or continue this medication if you have active liver disease or unexplained abnormal liver function tests as it may worsen liver function.
• Regular liver function tests are recommended during treatment, and if abnormalities persist, consider discontinuing the medication.
• Patients with a history of kidney problems should exercise caution, as the medication may increase the risk of muscle-related side effects.
• Avoid excessive alcohol consumption while on this medication, as it may increase the risk of liver-related side effects.
• This medication may cause muscle pain or weakness; if you experience these symptoms, contact your doctor immediately.
• Patients with diabetes or at risk of developing diabetes should monitor their blood sugar levels regularly, as this medication may increase blood sugar.
• Pregnant or breastfeeding women should consult their doctor before taking this medication, as it may pass into breast milk and affect the baby.

Following are the drug interactions for Ezetimibe 10mg, Rosuvastatin 20mg Tablet:

• Ezetimibe may increase the blood levels of Rosuvastatin, leading to an increased risk of muscle-related side effects and liver enzyme elevations.
• The combination of Ezetimibe and Rosuvastatin with other lipid-lowering agents like fibrates or niacin may increase the risk of rhabdomyolysis, a severe muscle breakdown.
• Avoid using Ezetimibe with bile acid sequestrants as it may reduce its absorption, thereby decreasing its effectiveness.
• It may interact with cyclosporine, increasing the risk of myopathy and rhabdomyolysis.
• Caution with oral anticoagulants like warfarin, as it may alter the INR (International Normalized Ratio) and require monitoring.
• Ezetimibe may increase the concentration of certain medications metabolized by CYP3A4, including some calcium channel blockers and immunosuppressants.
• Use with caution in patients taking protease inhibitors, as it may increase the exposure to Ezetimibe and Rosuvastatin.

Following are the food interactions for Ezetimibe 10mg, Rosuvastatin 20mg Tablet:

• Grapefruit and grapefruit juice should be avoided as they can interfere with the metabolism of Rosuvastatin, potentially increasing its levels in the blood and the risk of side effects, particularly muscle-related issues.
• Limit alcohol consumption as it can increase the risk of liver-related issues and may also interact with Rosuvastatin, affecting its effectiveness.
• Avoid high-fat meals as they can increase the absorption of Ezetimibe, which may lead to increased side effects.
• Ezetimibe may decrease the absorption of fat-soluble vitamins (A, D, E, and K), so ensure a balanced diet or consider supplementation if necessary.
• Rosuvastatin should be taken with or without food at the same time each day for consistent absorption.
• Avoid consuming large amounts of licorice as it can affect the metabolism of Rosuvastatin.
• Always inform your healthcare provider about your diet and any significant changes to ensure the medication's effectiveness and safety.
• No major food interactions have been reported with Ezetimibe, but it's best to consult your doctor for personalized advice.

Ezetimibe 10mg, Rosuvastatin 20mg tablets should be stored in a cool and dry place, preferably at room temperature, away from direct exposure to sunlight, moisture, and heat. The original container should be used to keep the medication sealed and protected from contamination. It is crucial to check the expiration date regularly and dispose of any unused or expired tablets appropriately. Do not flush the medication or throw it into the trash; instead, follow local guidelines or consult your pharmacist for safe disposal methods. Ensure that the medication is kept out of the sight and reach of children to prevent accidental consumption. Proper storage and disposal practices are essential to maintain the effectiveness of the medication and promote medication safety.

Following are the quick tips for Ezetimibe 10mg, Rosuvastatin 20mg Tablet:

• Always take the medication as directed by your doctor.
• Swallow the tablet whole with a full glass of water.
• Take it at the same time each day to maintain consistent blood levels.
• It can be taken with or without food, but be consistent with your choice.
• Do not crush, chew, or break the tablet, as it may affect its effectiveness.
• Inform your doctor about all medications you are taking to avoid potential interactions.
• Store the medication in a cool, dry place, away from direct sunlight and moisture.

Rosuvastatin and Ezetimibe are powerful medications that work in tandem to treat high cholesterol levels in the blood. These medications effectively reduce cholesterol levels by limiting cholesterol production in the liver and promoting its absorption in the intestines. To ensure the medications are performing their duty and to eliminate any potential health risks, it is crucial to monitor your health via appropriate laboratory tests. Regular cholesterol tests are necessary to assess your lipid profile, measuring cholesterol and triglyceride levels, including LDL ("bad" cholesterol) and HDL ("good" cholesterol). These tests ensure the medication regimen is working efficiently and prevent the risk of cholesterol building up in the arteries. Monitoring liver function tests are also essential, as Rosuvastatin primarily impacts the liver and, in rare cases, may cause liver damage. Tracking liver enzymes ensures the medication is not overly stressing the liver and helps identify any potential liver injury signs. ezetimibe can occasionally increase liver inflammation, so monitoring this through liver function tests is crucial. General blood tests like a complete blood count (CBC) and a C-reactive protein (CRP) test can also help monitor the medications' impact. A CBC can identify an immune system imbalance or anemia, common side effects of cholesterol-lowering drugs. The CRP test measures overall inflammation in the body, which may be elevated due to lifestyle or genetic factors that raise heart disease risks. CRP levels can inform adjustments to your treatment plan with your doctor's help. Although these medications are safe and effective, their impact should be monitored via appropriate lab tests to guarantee optimal health.