Xalatan (0.005%) 2.5ml Eye Drop

Latanoprost, the active ingredient in Latanoprost eye drops, acts primarily by mimicking the effects of prostaglandin F2α (PGF2α) on prostaglandin F receptors in the eye. When applied topically to the eye, Latanoprost binds to these receptors, mainly located on the ciliary muscle and trabecular meshwork. This binding activates specific signaling pathways, leading to an increase in the outflow of aqueous humor through the uveoscleral pathway. By enhancing this alternative drainage route, Latanoprost reduces intraocular pressure (IOP) by facilitating the drainage of fluid from the eye, which is its primary mechanism for treating conditions like ocular hypertension and open-angle glaucoma. The increased uveoscleral outflow is believed to result from remodeling of the extracellular matrix in the ciliary muscle and other tissues, allowing for improved fluid drainage.

Latanoprost

Prostaglandin Analog

drop

The following are the uses of Latanoprost Drop:

• Used for reducing high eye pressure in patients with open-angle glaucoma or ocular hypertension.
• Used for treating and controlling glaucoma, helping to lower intraocular pressure.
• Used for promoting eyelash growth as a side effect, leading to longer, thicker lashes.
• Used for slowing down the progression of glaucoma and preventing optic nerve damage.
• Used for improving drainage of fluids within the eye, reducing pressure on the optic nerve.
• Used for treating conditions like pigmentary glaucoma and pseudoexfoliative glaucoma.
• Used for managing post-surgical ocular hypertension after procedures like cataract surgery.
• Used for minimizing the risk of vision loss associated with elevated intraocular pressure.

To be used as per doctor's instructions

In the case of an overdose of Latanoprost Drops, it is important to remain calm and take appropriate actions. If ingested orally, contact poison control or a healthcare professional immediately for guidance. Do not induce vomiting unless instructed to do so. For eye drops, if an excessive amount is administered, gently wipe away the excess with a clean tissue and ensure proper dosage in future applications. Always consult a medical professional for specific advice and treatment options.

In the case of a missed dose of Latanoprost Drops, it is important to administer the medication as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not apply more than one drop in the affected eye(s) to make up for the missed dose, as this may lead to increased eye pressure and potential side effects. It is generally recommended to use the drops at the same time each day to maintain consistent medication levels in your eyes.

To use Latanoprost eye drops, wash your hands first, tilt your head back, gently pull down your lower eyelid, hold the dropper above the eye, dispense one drop into the pocket created, look downward and gently close your eyes for 1-2 minutes, and then blink to ensure the medication coats the eye.

Following are the conditions/situations when Latanoprost Eye Drops should not be used:

• Should not be used if you have a known allergy to Latanoprost or any other prostaglandin analogues.
• Not suitable for individuals with active eye infections or severe eye inflammation.
• Contraindicated in patients with a history of herpetic keratitis (a type of eye infection caused by herpes virus).
• Should not be used if you have a condition that affects the structure of your eye, such as narrow-angle glaucoma or certain types of lens disorders.
• Not recommended for individuals with a history of uveitis or retinal detachment.
• Avoid using these eye drops if you have a planned eye surgery or have recently had eye surgery.
• Do not use Latanoprost eye drops if you are using other similar medications for eye pressure or glaucoma.

The side effects of Latanoprost Eye Drops may include:

• Eye redness
• Itching or stinging sensation in the eyes
• Watery eyes
• Eyelid swelling
• Darkening of eye color (iris pigmentation)
• Blurred vision or visual disturbances
• Eyelash changes (increased length, thickness, or pigmentation)
• Increased sensitivity to light

Following are the precautions and warnings for Latanoprost Eye Drops:

• Avoid using Latanoprost if you have a known allergy to any of its ingredients, including preservatives.
• Exercise caution if you have a history of eye problems like macular edema, uveitis, or lens problems. Regular eye checks are essential during treatment.
• Contact lenses should be removed before applying the eye drops and can be reinserted after 15 minutes.
• May cause a temporary change in eye color and increased growth of eyelashes. Inform your doctor if you notice any changes.
• This medication is for external use only in the eyes. Do not swallow or inject.
• If you are using other eye drops, allow at least 5 minutes between applications to prevent washout.
• Discontinue use and consult a doctor if you experience severe eye pain, vision changes, or signs of an allergic reaction.
• Keep the bottle tightly closed when not in use and store in a cool, dry place.

Following are the drug interactions for Latanoprost Drop:

• Concomitant use with other ocular medications like beta-blockers or carbonic anhydrase inhibitors may increase intraocular pressure-lowering effects but can also cause additive side effects.
• Latanoprost may interact with topical corticosteroids, potentially increasing ocular pressure and reducing the effectiveness of the corticosteroid.
• Using Latanoprost with other prostaglandin analogs can lead to increased pigmentation of the iris and eyelashes.
• The absorption and effectiveness of Latanoprost can be reduced when used with ophthalmic solutions containing preservatives like benzalkonium chloride.
• Caution is advised when using Latanoprost with medications that cause myopia or changes in lens thickness, as these effects may be enhanced.
• Systemic absorption of Latanoprost can be increased with the use of ophthalmic non-steroidal anti-inflammatory drugs (NSAIDs), potentially leading to increased side effects.
• Latanoprost may interact with drugs affecting the cardiovascular system, such as calcium channel blockers or beta-blockers, due to its potential minor cardiovascular effects.

Following are the food interactions for Latanoprost Drops:

• Latanoprost is best absorbed when the eye is closed, so it is recommended to keep the eyes closed for at least 1-2 minutes after instilling the drop to minimize drainage and maximize effectiveness.
• Avoid consuming grapefruit or grapefruit juice while using Latanoprost, as it may decrease the drug's metabolism and increase its levels in the body, potentially leading to an increased risk of side effects.
• Alcohol consumption may cause temporary changes in eye pressure, so it is advisable to limit alcohol intake to ensure accurate eye pressure measurements when using Latanoprost.
• Caffeine-rich foods and beverages should be consumed in moderation, as caffeine may slightly elevate eye pressure, which could interfere with the treatment goal of Latanoprost to reduce intraocular pressure.
• While there are no specific food restrictions, maintaining a healthy and balanced diet is essential for overall eye health and can support the effectiveness of Latanoprost in managing eye conditions.
• It is advisable to avoid spicy foods that may cause eye irritation or discomfort, especially if you have sensitive eyes or any pre-existing eye conditions.
• Always follow the dosage instructions provided by your healthcare professional, and do not alter the dosage based on dietary preferences or changes.

Latanoprost eye drops should be stored at room temperature, ideally between 68°F and 77°F (20°C and 25°C). It is important to keep the bottle tightly closed and protected from light, so store it in its original packaging. Avoid freezing the eye drops and do not store them in the bathroom or near heat sources as temperature fluctuations can impact their effectiveness. Always check the expiration date on the bottle, and do not use the drops if they have expired. Dispose of any unused or expired Latanoprost eye drops by following local guidelines for pharmaceutical waste disposal; do not pour them down the sink or flush them down the toilet. Keep the medication out of the reach of children and pets to prevent accidental ingestion.

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Following are the quick tips for Latanoprost Drops:

• Wash your hands thoroughly before using the eye drops to maintain hygiene.
• Tilt your head back, gently pull down your lower eyelid, and instill the prescribed number of drops into the eye.
• Close your eyes gently and apply light pressure to the inner corner of the eye for 1-2 minutes to minimize drainage.
• Avoid touching the dropper tip to your eye or any surface to prevent contamination.
• If you are using other eye medications, wait at least 5 minutes before applying the next medication.
• Do not rinse the dropper; replace the cap after each use.
• Store the bottle upright and tightly closed at room temperature, away from direct sunlight and moisture.