Xaleve (400mg/4ml) 10 Injections For IV Infusion

Ibuprofen 400mg, a non-steroidal anti-inflammatory drug (NSAID), exerts its mechanism of action by inhibiting cyclooxygenase (COX) enzymes, primarily COX-1 and COX-2. These enzymes play a crucial role in the synthesis of prostaglandins, which are mediators of inflammation, pain, and fever. By blocking the action of COX enzymes, ibuprofen reduces the production of prostaglandins, thereby alleviating pain, lowering fever, and decreasing inflammation. It achieves this by competing with arachidonic acid for the active site of the COX enzymes, leading to a reduction in the formation of prostaglandin precursors. This mechanism underlies ibuprofen's effectiveness in managing various conditions characterized by pain, inflammation, and pyrexia.

Ibuprofen 400mg

Non-steroidal anti-inflammatory drug (NSAID)

Injection

The following are the uses of Ibuprofen 400mg Injection:

• Used for relieving acute pain, such as postoperative pain, and providing short-term pain management.
• Used for reducing inflammation and lowering fever in various conditions like rheumatoid arthritis, osteoarthritis, and other inflammatory disorders.
• Used for treating severe migraine attacks to provide rapid relief from pain and associated symptoms.
• Used for managing pain and inflammation in conditions like gout, ankylosing spondylitis, and other rheumatic diseases.
• Used for alleviating discomfort and reducing swelling following dental procedures or oral surgeries.
• Used for treating severe menstrual cramps and pain, providing quick relief during episodes of dysmenorrhea.
• Used for controlling pain and inflammation in injuries like sprains, strains, or minor fractures.

In the case of an overdose of Ibuprofen 400mg Injection, it is crucial to recognize the potential symptoms and act promptly. Overdose symptoms may include severe stomach pain, nausea, vomiting, and gastrointestinal bleeding. If an overdose is suspected, seek medical advice immediately. Quick action can help prevent potential complications, and medical professionals can provide guidance on appropriate treatment options to manage the overdose effectively. Timely intervention is key to ensuring the best possible outcome.

In the case of a missed dose of Ibuprofen 400mg Injection, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely adjust your dosing schedule. It is generally recommended to take the missed dose within a 2-3 hour window from the time it was originally scheduled.

To administer Ibuprofen 400mg Injection, clean the injection site with an antiseptic, insert the needle at a 90-degree angle, and slowly inject the entire contents of the vial into the muscle, ensuring the full dose is delivered.

Following are the conditions when Ibuprofen 400mg Injection should not be administered:

• Must not be used in individuals with a known allergy or hypersensitivity to Ibuprofen or other Non-Steroidal Anti-Inflammatory Drugs (NSAIDs).
• Contraindicated in patients with active or suspected gastrointestinal bleeding or ulceration.
• Should not be used in individuals with severe heart failure or heart disease.
• Not recommended for patients with severe kidney disease or on dialysis.
• Must be avoided in individuals with a history of severe asthma attacks or allergic reactions triggered by Aspirin or other NSAIDs.
• Contraindicated in pregnant women, especially during the third trimester, due to potential harm to the fetus.
• Should not be used in patients with bleeding disorders or those on blood-thinning medications.
• Not suitable for individuals with severe dehydration or low blood volume.

The side effects of Ibuprofen 400mg Injection may include:

• Stomach pain or upset
• Nausea and vomiting
• Diarrhea
• Dizziness or vertigo
• Headache
• Drowsiness or fatigue
• Skin reactions such as rash, itching, or hives
• Increased blood pressure

Following are the precautions and warnings for Ibuprofen 400mg Injection:

• Allergic reactions may occur; discontinue use if signs of an allergic reaction appear, such as rash, itching, or difficulty breathing.
• Prolonged use may lead to gastrointestinal issues like stomach pain, bleeding, or ulcers.
• Ibuprofen may cause increased risk of cardiovascular events; patients with heart disease should use with caution.
• Avoid using if you have a history of gastrointestinal bleeding or perforation.
• This medication may cause fluid retention and edema, especially in patients with pre-existing conditions like heart or kidney disease.
• Elderly patients may be more susceptible to adverse reactions; monitor closely.
• Ibuprofen can cause liver problems; monitor liver function, especially during long-term use.
• Not recommended for use during pregnancy and breastfeeding unless advised by a healthcare professional.

Following are the drug interactions for Ibuprofen 400mg Injection:

• Concomitant use with anticoagulants (e.g., warfarin, heparin) or antiplatelet drugs (e.g., aspirin, clopidogrel) may increase the risk of bleeding.
• Combining with other NSAIDs (e.g., naproxen, diclofenac) may increase the risk of gastrointestinal bleeding and kidney damage.
• Concurrent use with corticosteroids (e.g., prednisone, dexamethasone) may elevate the risk of gastrointestinal ulcers and bleeding.
• Co-administration with diuretics (e.g., furosemide, hydrochlorothiazide) may reduce diuretic effectiveness and increase the risk of kidney damage.
• Using with antihypertensive drugs (e.g., ACE inhibitors, ARBs, beta-blockers) may reduce their blood pressure-lowering effects.
• Nephrotoxic drugs (e.g., aminoglycosides, cyclosporine, tacrolimus) may increase the risk of kidney dysfunction when taken with Ibuprofen.
• Concomitant use with lithium may increase lithium levels, leading to toxicity.
• Methotrexate co-administration may enhance methotrexate toxicity due to decreased clearance.
• Combining with SSRIs (e.g., fluoxetine, sertraline) may increase the risk of gastrointestinal bleeding.
• Alcohol consumption may heighten the risk of gastrointestinal irritation, ulcers, and liver toxicity.

Following are the food interactions for Ibuprofen 400mg Injection:

• Avoid excessive alcohol consumption as it can increase the risk of gastrointestinal bleeding and liver toxicity when combined with Ibuprofen.
• Grapefruit and grapefruit juice should be consumed with caution as they may alter the metabolism of Ibuprofen, leading to increased drug levels and potential side effects.
• Caffeine-containing beverages like coffee and tea may increase the risk of gastrointestinal irritation and bleeding when taken with Ibuprofen.
• Avoid fatty or greasy foods as they can slow down the absorption of Ibuprofen, potentially reducing its effectiveness.
• Consuming large amounts of salt or salty foods may increase blood pressure, especially when combined with Ibuprofen's potential effect on blood pressure.
• Certain herbal supplements like Ginkgo Biloba and St. John's Wort may increase the risk of bleeding when taken with Ibuprofen.
• Ibuprofen can be taken with or without food, but a light meal is recommended to minimize stomach upset.
• Consult your healthcare provider for specific dietary recommendations based on your medical condition and medication regimen.

Ibuprofen 400mg Injection should be stored in a controlled environment, specifically in a cool and dry place, ensuring it remains protected from direct sunlight and moisture. It is crucial to maintain the integrity of the medication by keeping it in its original packaging, tightly sealed, to prevent contamination. Avoid exposing the injection to extreme temperatures, such as those found in bathrooms or near heat sources, as this can impact its effectiveness. Regularly check the expiration date, and if the medication is no longer needed or has expired, proper disposal is essential. Do not dispose of it in sinks or toilets; instead, consult healthcare professionals or pharmacists for guidance on safe disposal methods. Additionally, ensure the medication is stored securely, out of children's reach, to prevent accidental ingestion.

Following are the quick tips for Ibuprofen 400mg Injection:

• Administer the injection under medical supervision for accurate dosage and safe administration.
• Ensure the injection is given at the correct site and depth as instructed.
• Ibuprofen may be given with a small amount of liquid to help swallow, but avoid alcohol.
• Adhere to the prescribed dosage and treatment duration for maximum effectiveness.
• Inform your doctor if you have a history of gastrointestinal issues or cardiovascular problems.
• Avoid using Ibuprofen 400mg Injection if you have severe kidney or liver impairment.
• Store the injection at room temperature, away from direct sunlight and moisture.
• Do not reuse needles or syringes; dispose of them safely after use.