Xalia (2.5mg) 10 Tablets

Rivaroxaban is an anticoagulant medication that works by selectively inhibiting factor Xa, a key enzyme in the coagulation cascade. It blocks the active site of factor Xa, thereby preventing the conversion of prothrombin to thrombin and ultimately interrupting the intrinsic and extrinsic coagulation pathways. By inhibiting factor Xa, rivaroxaban directly interferes with the formation of thrombin and the subsequent generation of fibrin, which are essential for clot formation. This mechanism helps to prevent the excessive clotting of blood and reduces the risk of thromboembolic events without the need for anticoagulant monitoring.

Oral anticoagulant.

Oral

The following are the uses of Rivaroxaban 5mg Tablet:

• Used for preventing blood clots in patients after knee or hip replacement surgery.
• Used for the treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE).
• Used to reduce the risk of stroke and blood clots in patients with atrial fibrillation.
• Used to prevent blood clots in those with a history of DVT or PE.
• Used for long-term treatment to prevent recurrent blood clots.
• Used as an alternative for patients unable to take other anticoagulants.
• Used to improve blood flow and reduce the risk of clot-related complications.

In the case of an overdose of Rivaroxaban 5mg Tablets, it is important to act swiftly. The initial symptoms may include excessive bleeding, such as nosebleeds, bleeding gums, or easy bruising. If you suspect an overdose, contact a healthcare professional or poison control center immediately for guidance. They can provide specific instructions based on the individual's condition and the amount ingested. Prompt medical intervention is key to managing the potential risks associated with this medication.

In the case of a missed dose of Rivaroxaban 5mg Tablet, it is important to take the medication as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. However, if you have missed multiple doses or an entire day's worth of medication, contact your healthcare provider for guidance. They may advise you to take the missed dose immediately or provide alternative instructions to ensure the medication's effectiveness. It is crucial to maintain a consistent dosing schedule for this medication, so try to take it at the same time each day.

To take Rivaroxaban 5mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, without crushing or chewing, as directed by your healthcare professional.

Following are the conditions when Rivaroxaban 5mg Tablet should not be used:

• Should not be used in individuals with a known allergy to Rivaroxaban or other similar anticoagulant medications.
• Not suitable for patients with active bleeding or bleeding disorders.
• Contraindicated in patients with severe liver disease or liver problems.
• Should not be used in individuals with a history of stroke or transient ischemic attack (TIA).
• Not recommended for patients with recent spinal surgery or spinal injury.
• Avoid in patients with severe uncontrolled high blood pressure.
• Should not be used in patients with a mechanical prosthetic heart valve.
• Contraindicated during pregnancy and breastfeeding.
• Not suitable for individuals with severe kidney problems or on dialysis.
• Avoid if you have a stomach ulcer or a personal or family history of bleeding disorders.

The side effects of Rivaroxaban 5mg Tablet may include:

• Increased risk of bleeding, including nosebleeds, bleeding gums, or prolonged bleeding from cuts.
• Bruising easily.
• Headache or dizziness.
• Nausea and vomiting.
• Stomach pain or indigestion.
• Itching or rash.
• Muscle or joint pain.
• Fatigue or weakness.

Following are the precautions and warnings for Rivaroxaban 5mg Tablet:

• Patients with a history of bleeding disorders or conditions that increase the risk of bleeding should use this medication with caution, as it can increase the risk of bleeding.
• Not recommended for individuals with severe liver disease or liver impairment, as it may lead to increased drug levels in the body.
• Elderly patients may be more susceptible to bleeding risks, and close monitoring is advised.
• Patients undergoing spinal procedures or epidural anesthesia should inform their healthcare provider about Rivaroxaban use to prevent spinal hematomas.
• Should be used with caution in patients with kidney problems, as dosage adjustments might be necessary.
• Not recommended for individuals with active pathological bleeding, as it may exacerbate the condition.
• Patients with antiphospholipid syndrome are at a higher risk of arterial and venous thromboembolism and should be monitored closely.

Following are the drug interactions for Rivaroxaban 5mg Tablet:

• NSAIDs (e.g., ibuprofen, naproxen) and antiplatelet agents (e.g., aspirin, clopidogrel) may increase the risk of bleeding when used with Rivaroxaban.
• Rifampin, a strong CYP3A4/P-gp inducer, can significantly reduce Rivaroxaban plasma levels, potentially reducing its effectiveness.
• Ketoconazole, a strong CYP3A4/P-gp inhibitor, can increase Rivaroxaban plasma levels, leading to increased bleeding risk.
• Anticoagulants like warfarin or other vitamin K antagonists may elevate the risk of bleeding when combined with Rivaroxaban.
• Dual antiplatelet therapy with clopidogrel and aspirin, along with Rivaroxaban, increases bleeding risk.
• Drugs affecting hemostasis (e.g., thrombolytic agents, heparin) may enhance the anticoagulant effect of Rivaroxaban.
• Herbal supplements like St. John's Wort (Hypericum perforatum) can decrease Rivaroxaban plasma levels, potentially reducing its efficacy.

Following are the food interactions to be aware of with Rivaroxaban 5mg Tablet:

• Grapefruit and grapefruit juice consumption should be avoided as they can significantly increase Rivaroxaban levels in the blood, potentially leading to increased bleeding risks.
• Cranberry juice should be consumed with caution as it may affect the blood-thinning action of Rivaroxaban, although the mechanism is not fully understood.
• Green leafy vegetables rich in vitamin K, like spinach and kale, should be consumed consistently to maintain a stable vitamin K level. Abrupt changes in vitamin K intake can affect the drug's effectiveness.
• Alcohol can increase the risk of bleeding when taken with Rivaroxaban, and it is best to limit or avoid it.
• There are no direct food interactions that affect the absorption of Rivaroxaban, but maintaining a consistent diet is advisable.
• Consult your healthcare provider for personalized dietary advice, especially if you have specific dietary preferences or restrictions.
• Always inform your doctor about your current medications and dietary supplements to prevent potential interactions.

Rivaroxaban 5mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet, at room temperature (around 25°C). Keep the tablets in their original packaging, ensuring the container is tightly sealed to maintain its integrity and protect it from moisture. Avoid exposing the medication to direct sunlight or heat sources like radiators or ovens, as high temperatures can degrade its quality. When disposing of unused or expired tablets, do not flush them down the toilet or throw them into the trash. Instead, consult your pharmacist or local waste management guidelines for safe disposal practices to protect the environment and prevent unauthorized access. Always keep medications out of children's reach to prevent accidental consumption.

Following are the quick tips for Rivaroxaban 5mg Tablet:

• Take the tablet with a full glass of water at the same time each day.
• It can be taken with or without food, but take it consistently with food or without food each day.
• Do not break, crush, or chew the tablet; swallow it whole.
• If you have difficulty swallowing, you can dissolve the tablet in a glass of water or apple juice.
• Avoid grapefruit and grapefruit juice during treatment as they may affect the drug's effectiveness.
• Regularly monitor your blood pressure and kidney function while on this medication.
• Store the tablets at room temperature, away from moisture and heat.