Xaradol (325/37.5mg) 10 Tablets

Paracetamol and tramadol work together through a multi-step mechanism of action to provide effective pain relief. Paracetamol, an analgesic and antipyretic, functions primarily by inhibiting the synthesis of prostaglandins in the central nervous system. This reduces pain and fever while having minimal anti-inflammatory effects. Tramadol, an opioid analgesic, acts on the central nervous system by binding to μ-opioid receptors and inhibiting the reuptake of norepinephrine and serotonin. This dual action enhances its analgesic properties, providing relief from moderate to moderately severe pain. The combination of paracetamol and tramadol is often used to manage pain conditions where single-agent therapies may not be sufficient, offering synergistic effects for improved analgesia.

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Analgesic/Opioid

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Tablet

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Paracetamol , Tramadol is used for:

• Pain Relief
• Fever
• Moderate to Severe Pain Management

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Xaradol dosage for the indication of moderate to severe pain, duration as needed:

• Adults - 1 tablet every 6 hours as needed, not exceeding 8 tablets/day.
• Children - Not recommended.

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Paracetamol overdose can cause liver damage, while tramadol overdose may lead to respiratory depression. Seek emergency medical care.

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If you miss a dose, consume as soon as you remember. If it is close to the next feeding, skip the missed dose. Do not double up on doses.

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Paracetamol is taken every 4-6 hours as needed, while tramadol is usually taken every 6-8 hours. Follow the dosage instructions for each medication.

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Paracetamol + Tramadol should not be used if:

• Hypersensitivity
• Severe liver disease
• Concurrent use of MAO inhibitors (Tramadol)

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Possible side effects of Paracetamol and Tramadol include:

• Nausea
• Drowsiness
• Constipation
• Dizziness
• Allergic reactions

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The warnings and precautions for Paracetamol and Tramadol are:

• Patient with hypovolaemia, CV disease (including acute MI)
• History of seizures or risk factors for seizures (e.g., CNS infection, metabolic disorders, malignancy, alcohol/drug withdrawal), delirium tremens, head injury, intracranial lesions, elevated intracranial pressure, toxic psychosis, emotional disturbance including depression
• History of drug abuse or acute alcoholism
• Acute abdominal conditions, adrenal insufficiency (e.g., Addison disease)
• Biliary tract dysfunction, acute pancreatitis
• Prostatic hyperplasia, urinary stricture, significant COPD or cor pulmonale, substantially decreased respiratory reserve, hypoxia, hypercapnia, pre-existing respiratory depression
• G6PD deficiency, thyroid dysfunction
• Not recommended in patients with severe respiratory insufficiency
• Avoid use in patients with circulatory shock, impaired consciousness or coma, moderate to severe sleep-disordered breathing and suicidal patients
• Cachectic, debilitated or morbidly obese patients
• Avoid abrupt withdrawal
• Renal and mild to moderate hepatic impairment
• Elderly
• Pregnancy and lactation

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The drug interactions with paracetamol and tramadol include:

• CYP2D6 Inhibitors (e.g., fluoxetine) – Can increase tramadol levels.
• Other CNS Depressants – Can enhance CNS depressant effects of tramadol.

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For Paracetamol and Tramadol, food interactions that should be considered are:

• Taking with food may help enhance absorption.
• Avoid alcohol as it may increase the risk of side effects.

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Paracetamol and Tramadol should be stored at room temperature, protected from light and moisture. Keep them in their original containers and out of reach of children. Dispose of any expired or unused medications according to local disposal guidelines or through a drug take-back program.

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