Xinoxy 3g Eye Ointment

Oxytetracycline Dihydrate and Polymyxin B Sulphate work synergistically in the ointment formulation to combat bacterial infections. Oxytetracycline, a broad-spectrum tetracycline antibiotic, inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, preventing the attachment of aminoacyl-tRNA to the RNA-ribosome complex. This action halts the growth of susceptible bacteria. Polymyxin B Sulphate, a cyclic polypeptide antibiotic, disrupts the structure of the bacterial cell membrane, enhancing its permeability. This leads to the leakage of intracellular components, ultimately causing bacterial cell death. Together, these mechanisms provide effective control over a range of bacteria, particularly in superficial infections where topical administration is appropriate.

Antibiotic, Polymyxin.

Ointment

The following are the uses of Oxytetracycline Dihydrate 0.005, Polymyxin B Sulphate 10000IU Ointment:

• Used for treating bacterial infections in eyes, particularly those caused by susceptible bacteria.
• Used for eye infections in livestock and pets, aiding in the healing of corneal ulcers and conjunctivitis.
• Used for preventing the progression of bacterial eye infections, ensuring prompt treatment.
• Used for managing post-operative eye infections, reducing the risk of complications.
• Used for controlling infections in eyes damaged by foreign bodies, chemicals, or heat.
• Used for its broad-spectrum activity against various bacteria, providing effective coverage.
• Used for its synergistic effect when combined with other antibiotics, enhancing treatment outcomes.
• Used for promoting faster recovery and reducing the duration of eye infection symptoms.

In the case of an overdose of Oxytetracycline Dihydrate 0.005 and Polymyxin B Sulphate 10000IU Ointment, individuals may experience symptoms such as nausea, vomiting, and diarrhea. The severity of these symptoms can vary depending on the amount ingested. If an overdose occurs, it is important to seek medical advice promptly. Treatment may involve managing the symptoms and providing supportive care until the medication is eliminated from the body. Always consult a healthcare professional for guidance.

In the case of a missed dose of Oxytetracycline Dihydrate 0.005 and Polymyxin B Sulphate 10000IU Ointment, it is important to apply the medication as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply extra ointment to make up for the missed dose. It is recommended to maintain a consistent application routine, but if you have any concerns or frequently miss doses, consult your healthcare provider for further guidance on managing your medication schedule.

To apply Oxytetracycline Dihydrate 0.005, Polymyxin B Sulphate 10000IU Ointment, clean and dry the affected area, then gently apply a thin layer of the ointment using a sterile applicator or clean fingers, ensuring complete coverage, and follow the prescribed frequency of application as directed by your healthcare provider.

Following are the conditions or situations when Oxytetracycline Dihydrate 0.005, Polymyxin B Sulphate 10000IU Ointment should not be used:

• Do not use if you have a known allergy or hypersensitivity to any of the ingredients, including Oxytetracycline or Polymyxin B.
• Avoid using this ointment if you have a history of severe allergic reactions to other tetracycline or polymyxin antibiotics.
• Not suitable for individuals with a history of severe renal impairment or kidney disease.
• Should not be used in individuals with a history of severe liver impairment or liver disease.
• Contraindicated in patients with a history of myasthenia gravis.
• Avoid using this ointment if you have a known or suspected bacterial infection that is not responsive to the components of this medication.
• Do not use this ointment on open wounds, severe burns, or large areas of broken skin.
• Not recommended for individuals with a history of eczema or severe skin reactions.

The side effects of Oxytetracycline Dihydrate 0.005, Polymyxin B Sulphate 10000IU Ointment may include:

• Skin irritation at the application site
• Redness or swelling
• Itching or burning sensation
• Dryness or peeling of the skin
• Allergic reactions (e.g., rash, hives)
• Temporary blurred vision (if applied near the eyes)
• Ear discomfort or irritation (if used in the ear)

Following are the precautions and warnings for Oxytetracycline Dihydrate 0.005, Polymyxin B Sulphate 10000IU Ointment:

• Do not use if you are allergic to any of the ingredients, especially tetracycline antibiotics or polymyxin B.
• Avoid contact with eyes and mucous membranes; if accidental contact occurs, rinse thoroughly with water.
• Do not use this ointment if you are pregnant or breastfeeding without medical advice, as it may harm the fetus or pass into breast milk.
• This medication should not be used for prolonged periods, as it may lead to bacterial resistance and skin sensitization.
• Discontinue use if you experience severe skin irritation, redness, or allergic reactions.
• Keep out of reach of children. If accidentally ingested, seek medical attention immediately.
• Store the ointment as directed on the packaging, usually at room temperature, away from direct sunlight and moisture.

Following are the drug interactions for Oxytetracycline Dihydrate 0.005, Polymyxin B Sulphate 10000IU Ointment:

• Oxytetracycline may decrease the effectiveness of hormonal contraceptives, including birth control pills, patches, and rings, as well as emergency contraception. Consider using alternative contraceptive methods during and immediately after treatment.
• Antacids containing aluminum, calcium, or magnesium can reduce the absorption of oxytetracycline. Take this medication at least 2 hours before or 4 hours after taking antacids.
• Tetracycline antibiotics, including oxytetracycline, can interact with isotretinoin, increasing the risk of intracranial hypertension (increased pressure in the skull). This combination should be avoided.
• The use of oxytetracycline with other drugs that can cause kidney damage, such as nonsteroidal anti-inflammatory drugs (NSAIDs), may increase the risk of kidney-related side effects.
• Oxytetracycline may increase the blood levels of digoxin, a heart medication, potentially leading to digoxin toxicity. Close monitoring of digoxin levels is recommended.
• It can interact with warfarin, a blood thinner, and may increase the risk of bleeding. Regular monitoring of coagulation parameters is advised.
• The effectiveness of oxytetracycline may be reduced when taken with bismuth subsalicylate. Separate the administration of these drugs by at least 2 hours.

Following are the food interactions for Oxytetracycline Dihydrate 0.005, Polymyxin B Sulphate 10000IU Ointment:

• Dairy products, calcium-rich foods, and antacids containing calcium or aluminum should be avoided as they can reduce the absorption of Oxytetracycline, decreasing its effectiveness.
• Iron-rich foods, such as red meat, liver, and iron supplements, should be taken at different times than Oxytetracycline, as iron can bind with the antibiotic and reduce its absorption.
• Vitamin A-rich foods, like liver and fish liver oils, may increase the risk of vitamin A toxicity when taken with Oxytetracycline, as it can interfere with vitamin A metabolism.
• Avoid excessive alcohol consumption as it may increase the risk of liver-related side effects when combined with Polymyxin B.
• Polymyxin B may interact with certain foods containing high levels of sodium or potassium, potentially affecting electrolyte balance.
• There are no direct food interactions with Polymyxin B Sulphate, but maintaining a balanced diet is recommended for overall health.
• Consult your healthcare provider for specific dietary advice, especially if you have any underlying medical conditions.

Oxytetracycline Dihydrate 0.005, Polymyxin B Sulphate 10000IU Ointment should be stored in a controlled environment, maintaining a cool and dry atmosphere. It is crucial to keep the ointment in its original packaging, tightly sealed, to maintain its integrity and prevent contamination. Avoid exposing the medication to direct sunlight, heat, or moisture, as these factors can degrade its quality. Dispose of any remaining or expired ointment responsibly; refrain from discarding it in sinks, toilets, or drains. For appropriate disposal methods, consult your pharmacist or healthcare professional. Always exercise caution to keep all medications securely stored and out of the reach of children to prevent accidental ingestion.

Following are the quick tips for Oxytetracycline Dihydrate 0.005, Polymyxin B Sulphate 10000IU Ointment:

• Wash your hands thoroughly before and after applying the ointment to maintain hygiene.
• Clean and dry the affected area before applying the ointment for better absorption.
• Apply a thin layer of the ointment and gently rub it into the skin as directed by your doctor.
• Avoid applying the ointment to broken or damaged skin to prevent irritation.
• Do not cover the treated area with bandages or dressings unless instructed by your healthcare provider.
• Store the ointment at room temperature, away from direct sunlight and moisture.
• Inform your doctor if you have any known allergies to antibiotics before using this medication.