Xorbact (500mg) 5ml, 1 Ampoule Injection

Cefoperazone is a third-generation cephalosporin antibiotic that exerts its bactericidal effect by binding to specific penicillin-binding proteins (PBPs) and inhibiting the final stage of bacterial cell wall synthesis. This disrupts the formation of the cell wall, leading to cell lysis. Sulbactam, a beta-lactamase inhibitor, protects cefoperazone from degradation by inhibiting beta-lactamase enzymes produced by certain bacteria, thus enhancing its activity against a broader spectrum of bacteria, including some beta-lactamase-producing organisms.

Cefoperazone 250mg, Sulbactam 250mg

Third-generation cephalosporin/beta-lactamase inhibitor

Injection

The following are the uses of Cefoperazone 250mg, Sulbactam 250mg injection:

• Used for treating severe bacterial infections that require hospitalization, such as complicated urinary tract infections and skin and soft tissue infections.
• Used for managing intra-abdominal infections, including those post-surgery or related to the gastrointestinal tract.
• Used for controlling infections caused by a broad range of bacteria, including E. coli and Klebsiella species.
• Used for combating infections in patients with compromised immune systems or those at risk of mixed bacterial infections.
• Used for preventing the progression of severe infections that may lead to sepsis.
• Used for treating patients with a history of bacterial resistance to other antibiotics.
• Used for providing rapid and effective action against rapidly spreading infections.

In the case of an overdose of Cefoperazone 250mg and Sulbactam 250mg injection, individuals may experience an increased risk of adverse effects. Symptoms can include nausea, vomiting, diarrhea, and potential allergic reactions. In severe cases, an overdose may lead to more serious complications such as seizures, kidney damage, or anaphylaxis. It is important to seek medical advice promptly if an overdose is suspected, as appropriate treatment and monitoring may be necessary to manage any adverse effects and ensure the patient's well-being.

In the case of a missed dose of Cefoperazone 250mg and Sulbactam 250mg injection, it is important to administer the medication as soon as possible. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one. It is recommended to set reminders or alarms to help remember medication timings and ensure a consistent dosing routine. Consult your healthcare provider if you have any concerns or if you miss multiple doses.

To administer Cefoperazone 250mg and Sulbactam 250mg injection, prepare the medication by drawing the prescribed dose into a syringe, then inject it slowly into the vein or muscle as directed by your healthcare provider, ensuring proper hygiene and sterile techniques are followed.

Following are the conditions when Cefoperazone 250mg, Sulbactam 250mg injection should not be used:

• Should not be administered to patients with a history of severe allergic reactions to Cefoperazone, Sulbactam, or other beta-lactam antibiotics.
• Contraindicated in patients with a known allergy to penicillins, as cross-reactivity may occur.
• Not recommended for patients with a history of severe diarrhea or colitis associated with antibiotic use.
• Should be avoided in patients with severe kidney disease or impaired kidney function, as dosage adjustments are necessary.
• Not suitable for neonates, especially premature infants, due to the risk of bilirubin encephalopathy.
• Contraindicated in patients with a history of Stevens-Johnson syndrome or toxic epidermal necrolysis.
• Should not be used in patients with a known or suspected Clostridioides difficile (C. difficile) infection or colitis.

The side effects of Cefoperazone 250mg, Sulbactam 250mg injection may include:

• Skin rash, itching, hives, swelling of the face, lips, or tongue.
• Nausea, vomiting, diarrhea, abdominal pain.
• Headache, dizziness, confusion, seizures (rare).
• Pain, redness, swelling, or irritation at the injection site.
• Decreased white blood cell count, thrombocytopenia (low platelet count).
• Increased blood urea nitrogen (BUN) and creatinine levels.
• Overgrowth of non-susceptible bacteria or fungi.
• Abnormal liver function tests.

Following are the precautions and warnings for Cefoperazone 250mg, Sulbactam 250mg injection:

• This medication should not be used in patients with a history of severe allergic reactions to cephalosporin antibiotics or penicillins.
• It should be used with caution in patients with kidney or liver disease, as dosage adjustments may be necessary.
• Cefoperazone can cause diarrhea, and if it becomes severe or persistent, it may indicate a more serious condition. Patients should be monitored for Clostridium difficile-associated diarrhea.
• Long-term or repeated use may result in bacterial or fungal overgrowth, requiring appropriate measures.
• Elderly patients may be more susceptible to adverse effects; careful monitoring is advised.
• It should be used with caution during pregnancy and breastfeeding, only if the potential benefits outweigh the risks.
• Patients with a history of gastrointestinal diseases or colitis should be closely monitored during treatment.

Following are the drug interactions for Cefoperazone 250mg, Sulbactam 250mg injection:

• May reduce the effectiveness of oral contraceptives, requiring alternative contraceptive methods during and after treatment.
• Probenecid can increase the levels of Cefoperazone, potentially enhancing its side effects.
• Nephrotoxic drugs (e.g., aminoglycosides, furosemide) may increase the risk of kidney damage when used with Cefoperazone.
• Concurrent use with other antibiotics like vancomycin may increase the risk of antibiotic-associated colitis.
• Sulbactam may reduce the efficacy of methotrexate, requiring close monitoring.
• May affect the results of certain blood glucose tests, leading to inaccurate readings.
• The use of muscle relaxants with Cefoperazone may prolong neuromuscular blockade.

Following are the food interactions for Cefoperazone 250mg, Sulbactam 250mg injection:

• Avoid consuming alcohol during and a few days after the treatment, as it may increase the risk of side effects and reduce the effectiveness of the medication.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of the drug, leading to increased levels in the body.
• High-fat meals may delay the absorption of Cefoperazone, potentially affecting its peak concentration and time to reach it.
• Avoid taking antacids containing magnesium or aluminum within 1-2 hours of this medication, as they can reduce its absorption.
• Dairy products like milk, yogurt, and cheese should be consumed with caution as they can potentially reduce the absorption of Cefoperazone.
• Vitamin supplements, especially calcium and iron, can interfere with the absorption of this medication and should be taken at different times.
• Avoid caffeine or limit its intake as it can potentially increase the side effects associated with this medication, such as nervousness and insomnia.
• No significant interaction with specific foods, but maintaining a balanced diet is essential to support overall health during treatment.

Cefoperazone 250mg and Sulbactam 250mg injection should be stored in a controlled environment, preferably in a cool and dry place, maintaining a temperature between 20°C to 25°C (68°F to 77°F). Protect the injection from direct sunlight, moisture, and heat sources to ensure its stability. Always keep the medication in its original packaging, tightly sealed, to maintain its integrity. Prioritize disposing of unused or expired injections responsibly; avoid flushing them down the toilet or into the drainage system. Contact your local pharmacist or healthcare provider for guidance on proper disposal methods. Remember to keep all medications securely stored and out of children's reach to prevent accidental exposure.

Following are the quick tips for Cefoperazone 250mg, Sulbactam 250mg injection:

• Administer the injection as prescribed by your doctor for the entire course.
• Ensure the injection is prepared and administered by a trained healthcare professional.
• Cefoperazone and Sulbactam are typically given intravenously, and the injection site should be cleaned before use.
• The injection can be given slowly over 3-5 minutes or as an infusion over 30 minutes.
• To reduce the risk of discomfort, ensure the injection is at room temperature before use.
• Store the injection as directed, usually at room temperature, away from direct sunlight.
• Do not use if the solution is discolored or contains particles, and inform your healthcare provider.