Xynosine (0.1%) 15ml Nasal Drops

Xylometazoline, the active ingredient in Xylometazoline nasal drops, is a sympathomimetic amine that primarily acts on alpha-adrenergic receptors in the nasal mucosa. Its mechanism of action involves binding to these receptors, which leads to vasoconstriction of the blood vessels in the nasal passages. This constriction reduces blood flow to the nasal mucosa, resulting in decreased swelling, congestion, and inflammation. By narrowing the blood vessels, xylometazoline helps to shrink the swollen nasal tissues, thereby opening up the nasal airways and providing relief from nasal congestion. This action facilitates easier breathing and helps alleviate symptoms associated with conditions such as the common cold, sinusitis, or allergic reactions.

Vasoconstrictor.

Drop

The following are the uses of Xylometazoline Drop:

• Used for temporarily relieving nasal congestion caused by colds, allergies, or sinusitis.
• Used to reduce swelling in the nasal passages, allowing easier breathing.
• Used to treat symptoms of nasal congestion and stuffiness.
• Used for providing short-term relief from nasal discomfort.
• Used for helping to shrink swollen blood vessels in the nose, easing congestion.
• Used in cases of sinus pressure and pain, offering temporary relief.
• Used to clear blocked noses, especially in cases of hay fever or flu.

To be taken as per doctor's prescription

In the case of an overdose of Xylometazoline Drops, the primary concern is the potential for severe side effects, particularly in children. Overuse can lead to increased blood pressure, rapid heart rate, and even seizures. Symptoms may include dizziness, headache, and nausea. Immediate action should be taken, including contacting a poison control center or seeking medical advice. Prompt treatment can help mitigate the risks and ensure a full recovery.

In the case of a missed dose of Xylometazoline Drops, it is important to administer the medication as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Avoid doubling the dose to make up for a missed one, as this may lead to excessive medication intake. Consult your healthcare professional if you have any concerns or if you miss multiple doses, as they can provide guidance tailored to your specific needs.

To administer Xylometazoline Drops, tilt your head back, gently squeeze the prescribed number of drops into each nostril, and breathe in slowly to ensure the medication reaches the nasal passages.

Here are the conditions and situations when Xylometazoline Drops should not be used:

• Avoid using if you have an allergy or sensitivity to Xylometazoline or any other similar nasal decongestants.
• Do not use if you have recently undergone nasal surgery or have untreated nasal injuries.
• Contraindicated in individuals with severe cardiovascular diseases, including uncontrolled high blood pressure.
• Not suitable for people with overactive thyroid (hyperthyroidism).
• Avoid using if you have narrow-angle glaucoma.
• Should not be used in individuals with severe kidney disease.
• Not recommended for infants and young children, especially under 6 years of age.
• Discontinue use if you experience severe side effects such as rapid heartbeat, severe headache, or severe nasal irritation.
• Do not use Xylometazoline if you are currently taking Monoamine Oxidase Inhibitors (MAOIs) or have taken them within the last 14 days.
• Avoid prolonged use as it may lead to rebound congestion.

The side effects of Xylometazoline Drops may include:

• Nasal irritation or dryness
• Rebound congestion or increased nasal discharge after prolonged use
• Sneezing
• Headache
• Dizziness
• Burning or stinging sensation in the nose
• Fatigue or drowsiness
• Increased blood pressure

Following are the precautions and warnings for Xylometazoline Nasal Drops:

• Do not exceed the recommended dosage or duration of use, typically no longer than 3-5 days, unless directed by a healthcare professional.
• Not recommended for children under 6 years of age without medical advice.
• Avoid using if you have a history of high blood pressure, heart disease, or thyroid problems without consulting a doctor.
• Xylometazoline can cause a temporary increase in blood pressure, so monitor blood pressure if you have hypertension.
• Discontinue use and seek medical attention if symptoms worsen, persist for more than a few days, or if side effects such as severe burning, stinging, or increased nasal congestion occur.
• Do not use if the nasal solution changes color or becomes cloudy.
• Consult a doctor if you are pregnant, planning to become pregnant, or breastfeeding before using this medication.

Following are the drug interactions for Xylometazoline Drop:

• Drugs that can cause drowsiness, such as opioids, benzodiazepines, or antihistamines, may have an additive effect when used with Xylometazoline, leading to increased sedation.
• The effect of Xylometazoline may be reduced by medications that narrow the blood vessels, like certain decongestants or beta-blockers.
• Antihypertensive medications' effectiveness can be diminished as Xylometazoline may increase blood pressure.
• Combining Xylometazoline with tricyclic antidepressants may enhance the risk of cardiovascular side effects.
• The risk of arrhythmias may increase when used with medications that affect heart rhythm, such as antiarrhythmic drugs.
• Xylometazoline may interact with other nasal medications or drops, potentially leading to reduced efficacy or increased side effects.
• Drugs that affect the central nervous system, like stimulants or antipsychotics, could have their effects altered when taken with Xylometazoline.

Following are the food interactions to be aware of when using Xylometazoline Drops:

• Avoid consuming alcohol during the use of these drops as it may cause increased drowsiness and affect your alertness.
• Grapefruit and its juice should be avoided as they can interfere with the medication's metabolism, potentially leading to increased side effects.
• Hot and spicy foods may further irritate the nasal passages and exacerbate symptoms, so it is best to avoid them while using the drops.
• Dairy products, especially milk, can cause increased mucus production, potentially reducing the effectiveness of the medication.
• Caffeinated beverages might increase blood pressure and heart rate, which is important to consider if you have cardiovascular issues.
• Sugary foods and drinks can impact the absorption and effectiveness of Xylometazoline, so it is advisable to limit their consumption.
• Stay well-hydrated by drinking plenty of water to help thin the mucus and support the medication's effectiveness.
• Avoid menthol-containing foods or drinks as they can cause a burning sensation and may interact with the medication.

Xylometazoline Drops should be stored in a secure and child-resistant container, preferably in a cool and dry place, maintaining a temperature between 15-25°C (59-77°F). Protect the drops from direct sunlight, heat, and moisture to ensure their effectiveness and prevent degradation. Always keep the medication in its original packaging, tightly sealed, to maintain its integrity and avoid contamination. It is crucial not to freeze the drops as it may alter their composition. When disposing of the medication, do not flush it down the toilet or pour it into a drain. Instead, follow local guidelines or consult your pharmacist for safe disposal methods to protect the environment. Keep the medication away from children and pets to prevent accidental ingestion.

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Following are the quick tips for Xylometazoline Drops:

• Wash your hands before administering the drops to ensure hygiene.
• Tilt your head back slightly and instill the prescribed number of drops into each nostril.
• Close your nostril gently and breathe in to help the medicine reach the nasal passages.
• Avoid blowing your nose immediately after using the drops for better effectiveness.
• Do not use the drops for longer than the recommended duration to prevent rebound congestion.
• Store the drops at room temperature, away from direct sunlight and moisture.
• Consult your doctor if symptoms persist or worsen after using the drops for a few days.