Zaclovir (5%) 10g Cream

Acyclovir 0.05% cream primarily acts by inhibiting the replication of herpes simplex virus (HSV). It specifically targets the viral DNA polymerase, a crucial enzyme for the virus's ability to multiply. Acyclovir is a synthetic nucleoside analogue that resembles guanine, one of the building blocks of DNA. When HSV-infected cells incorporate acyclovir into viral DNA, it acts as a chain terminator, preventing further elongation of the DNA strand. This effectively halts the replication process, limiting the spread of the virus within the body. By selectively interfering with viral DNA synthesis, acyclovir cream helps control the symptoms and progression of HSV-related skin infections, such as cold sores and genital herpes.

Acyclovir 0.05

Antiviral Cream

Cream

The following are the uses of Acyclovir 0.05 Cream:

• Used for treating genital herpes, providing relief from symptoms and helping sores heal faster.
• Used for managing recurrent genital herpes outbreaks, reducing their frequency and severity.
• Used for soothing skin irritation and promoting healing in affected areas.
• Used for preventing the spread of the herpes virus to reduce transmission risk.
• Used for alleviating pain and discomfort associated with genital herpes lesions.
• Used for accelerating the healing process, shortening outbreak duration.
• Used for minimizing the risk of viral shedding, lowering the chances of infecting others.
• Used for improving overall comfort and quality of life during genital herpes episodes.

In the case of an overdose of Acyclovir 0.05% Cream, it is important to note that the cream is intended for topical use and is generally well-tolerated. However, if ingested in large quantities, it may lead to potential side effects such as gastrointestinal discomfort, including nausea and vomiting. If an overdose occurs, it is recommended to contact a healthcare professional or a poison control center for guidance and to seek medical advice on the appropriate course of action.

In the case of a missed dose of Acyclovir 0.05% Cream, it is generally recommended to apply the cream as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you have any concerns or if you miss multiple doses, contact your healthcare provider for guidance on how to proceed with your treatment plan. They will be able to advise you on the best course of action to ensure the effectiveness of the medication.

To apply Acyclovir 0.05% Cream, clean and dry the affected area, then gently apply a thin layer of the cream to the skin, typically 5 times a day or as directed by your healthcare provider, ensuring you wash your hands before and after application.

Here are the conditions or situations when Acyclovir 0.05% Cream should not be used:

• Do not use if you are allergic to acyclovir or any other ingredients in the cream.
• Avoid using Acyclovir cream if you have a known hypersensitivity or severe reaction to similar antiviral medications.
• Not recommended for individuals with a compromised immune system or conditions that significantly impair the immune response.
• Do not apply to eyes, mouth, nose, or other mucous membranes; only for external skin use.
• Avoid using Acyclovir cream on open wounds, cuts, or severely inflamed skin areas.
• Discontinue use and consult a doctor if you experience severe or persistent skin reactions or if your condition worsens.

The side effects of Acyclovir 0.05% Cream may include:

• Itching or irritation at the application site
• Redness or swelling of the skin
• Dry or flaky skin
• Burning or stinging sensation
• Allergic reactions (skin rash, hives)
• Pain or tenderness in the affected area
• Mild skin peeling

Following are the precautions and warnings for Acyclovir 0.05% Cream:

• Do not use if you are allergic to Acyclovir or any of its ingredients.
• Avoid applying the cream near your eyes, mouth, or open wounds, and do not ingest it.
• Wash your hands thoroughly before and after applying the cream to avoid unnecessary exposure.
• Consult a doctor if you are pregnant, planning to become pregnant, or breastfeeding, as Acyclovir may pose risks to the fetus or infant.
• Do not cover the treated area with bandages or tight clothing, as this may increase the absorption of the medication.
• Avoid using other topical medications on the same area without medical advice to prevent potential interactions.
• If you have a weakened immune system or are using Acyclovir for prolonged periods, regular monitoring by a healthcare professional is recommended.
• Discontinue use and seek medical attention if you experience severe or persistent side effects, such as skin irritation, burning, or signs of a severe allergic reaction.

Following are the drug interactions for Acyclovir 0.05% Cream:

• Acyclovir may interact with other topical medications, especially those containing propylene glycol, potentially causing increased skin irritation.
• Concomitant use with other antiviral drugs like valacyclovir or famciclovir may increase the risk of renal toxicity, requiring close monitoring of kidney function.
• Topical corticosteroids, when used with Acyclovir cream, might mask the symptoms of a potential viral infection, delaying proper diagnosis and treatment.
• The use of Acyclovir cream alongside other medications that affect the immune system, such as immunosuppressants, could theoretically impact the body's ability to fight infections.
• Caution is advised when applying Acyclovir cream on skin treated with peeling agents or other exfoliating products, as it may increase skin sensitivity and the risk of adverse reactions.
• Some live virus vaccines may have reduced effectiveness when administered while using Acyclovir cream, as it may interfere with the replication of the vaccine virus.
• While not a drug, exposure to sunlight or UV light after applying Acyclovir cream might cause skin sensitivity, so patients should be advised to use sunscreen and protective clothing.

Following are the food interactions for Acyclovir 0.05% Cream:

• Acyclovir cream is for topical use only and should not be ingested, so there are no direct food interactions to consider.
• Ensure you wash your hands thoroughly before and after applying the cream to avoid accidental ingestion of the medication.
• Avoid applying the cream to areas near the mouth to prevent accidental swallowing.
• If you are using the cream on your lips, be cautious and ensure you do not lick or eat immediately after application.
• Avoid eating spicy or acidic foods that may irritate the skin, especially if you are using the cream to treat oral herpes.
• The cream should be applied as directed, and you should avoid eating or drinking for a short period after application to ensure proper absorption.
• Consult your healthcare provider if you have concerns about potential interactions with oral medications you may be taking.

Acyclovir 0.05% Cream should be stored in a cool and dry place, preferably at room temperature (around 25°C or 77°F). Protect the cream from excessive heat, direct sunlight, and moisture to maintain its effectiveness. Keep the tube tightly sealed when not in use to prevent contamination. It is crucial to dispose of any expired or unused cream properly, ensuring it is not flushed down the toilet or poured into drains. For safe disposal methods, consult your pharmacist or healthcare professional. Keep this medication out of children's reach to prevent accidental exposure, as it is meant for external use only.

Following are the quick tips for Acyclovir 0.05% Cream:

• Use this cream exactly as directed by your healthcare provider for optimal results.
• Wash your hands before and after applying the cream to prevent the spread of infection.
• Apply a thin layer to the affected area and gently rub it in until absorbed.
• Start using the cream as soon as symptoms appear for the best effectiveness.
• Avoid touching or scratching the affected area to prevent further irritation or spreading.
• Do not apply the cream inside the mouth, eyes, or nose; if contact occurs, rinse thoroughly with water.
• Store the cream in a cool, dry place, away from direct sunlight and heat.
• Keep out of reach of children to prevent accidental use or ingestion.