ZANSULIN 70/30 ING

Isophane Insulin Human is a modified form of human insulin with an intermediate duration of action. It forms microcrystals upon injection, leading to a slower and more sustained release of insulin into the bloodstream. This mechanism provides a steadier insulin level over an extended period, helping to control blood glucose levels between meals and overnight. Soluble Insulin Human injection, on the other hand, is a rapid-acting form of insulin. It is designed to be quickly absorbed into the bloodstream, mimicking the body's natural insulin response to a meal. This rapid onset of action allows for precise control of blood glucose levels, particularly after meals, when blood sugar tends to rise.

Isophane Insulin Human, Soluble Insulin Human

Insulin analogs, Insulin

injection

The following are the uses of Isophane Insulin Human, Soluble Insulin Human injection:

• Used for managing type 1 and type 2 diabetes mellitus
• Used to improve blood sugar control and reduce hyperglycemia
• Used to treat diabetic ketoacidosis and hyperosmolar hyperglycemic states
• Used for managing gestational diabetes during pregnancy
• Used as a long-acting insulin for basal glucose control
• Used for insulin replacement therapy in insulin-dependent patients
• Used to prevent long-term diabetes complications by maintaining stable blood sugar levels

In the case of an overdose of Isophane Insulin Human or Soluble Insulin Human injection, the individual may experience hypoglycemia, characterized by symptoms such as dizziness, sweating, tremors, and confusion. Prompt action is required, including the consumption of fast-acting carbohydrates like glucose tablets or juice to raise blood sugar levels. It is important to monitor blood glucose regularly and seek medical advice to prevent potential complications from prolonged hypoglycemia.

In the case of a missed dose of Isophane Insulin Human, administer the injection as soon as you remember, but if it's almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. For Soluble Insulin Human, if you miss a dose, take it as soon as possible, however, if it's almost time for your next dose, skip the missed dose and return to your regular dosing schedule. Do not double the dose to make up for a missed one.

To administer the Isophane Insulin Human and Soluble Insulin Human injection, clean the injection site with alcohol, insert the needle at a 90-degree angle, and slowly inject the prescribed dose subcutaneously, ensuring the injection is completed within 5-10 seconds.

Following are the conditions when Isophane Insulin Human, Soluble Insulin Human injection should not be used:

• Not recommended for individuals with a known allergy to insulin or any of its components.
• Contraindicated in cases of severe hypoglycemia (low blood sugar) without the ability to recognize or treat it.
• Should not be used during episodes of diabetic ketoacidosis (a serious complication of diabetes).
• Not suitable for individuals with severe kidney or liver disease.
• Should not be administered if the patient is in a state of diabetic coma or is unresponsive.
• Contraindicated in individuals with a history of hypersensitivity reactions to insulin.
• Not recommended for use during breastfeeding, as insulin can pass into breast milk.

The side effects of Isophane Insulin Human and Soluble Insulin Human injection may include:

• Hypoglycemia (low blood sugar)
• Allergic reactions (skin rash, itching, swelling)
• Injection site reactions (redness, pain, or swelling)
• Weight gain
• Edema (fluid retention)
• Blurred vision
• Weakness or dizziness
• Anxiety or confusion

Following are the precautions and warnings for Isophane Insulin Human and Soluble Insulin Human injection:

• Not suitable for individuals with a known allergy to insulin or any of the ingredients in the formulation.
• Requires careful monitoring of blood sugar levels, and adjustments may be needed based on individual response.
• Caution is advised in patients with kidney or liver disease, as insulin dosages may need to be adjusted.
• Hypoglycemia (low blood sugar) is a potential risk; patients should be educated on its symptoms and appropriate actions.
• Should be used with caution in elderly patients, as they may be more sensitive to its effects.
• Injection site reactions may occur; rotate injection sites to minimize skin irritation.
• Patients should be aware of the signs of hyperglycemia (high blood sugar) and seek medical attention if it occurs.
• Consult a healthcare professional before use during pregnancy or breastfeeding to ensure proper blood sugar management.

Following are the drug interactions for Isophane Insulin Human, Soluble Insulin Human injection:

• Alcohol intake may either increase or decrease the blood glucose-lowering effect of insulin.
• Oral contraceptives, corticosteroids, thyroid hormones, and sympathomimetic agents (e.g., epinephrine, albuterol) may decrease the blood glucose-lowering effect of insulin.
• Beta-blockers, clonidine, lithium salts, and angiotensin-converting enzyme (ACE) inhibitors may mask the symptoms of hypoglycemia or hyperglycemia.
• Octreotide and lanreotide may result in decreased requirements for insulin.
• Pentamidine may cause hypoglycemia, which may be followed by hyperglycemia.
• Certain medications like beta-adrenergic blockers, clonidine, lithium, and angiotensin-converting enzyme (ACE) inhibitors may affect glucose metabolism.
• Protease inhibitors used in the treatment of HIV may increase or decrease blood glucose levels.

Following are the food interactions for Isophane Insulin Human and Soluble Insulin Human injection:

• Avoid excessive alcohol consumption as it can interfere with blood sugar control and may increase the risk of hypoglycemia, especially when combined with insulin therapy.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect blood glucose levels and potentially interfere with insulin action.
• High-sugar foods and beverages should be consumed in moderation as they can cause rapid increases in blood sugar levels.
• Carbohydrate-rich foods are essential to include in meals and snacks to ensure a balanced blood sugar response to insulin.
• Monitor blood glucose levels closely when consuming foods with a high glycemic index, as they can lead to rapid spikes in blood sugar.
• Avoid high-fat meals as they may delay the absorption of insulin, making blood sugar control more challenging.
• A consistent and balanced diet is crucial for effective blood sugar management while using these insulin medications.
• Always follow the dietary guidelines provided by your healthcare professional for optimal blood glucose control.

Isophane Insulin Human and Soluble Insulin Human injection should be stored in a cool, controlled environment, ideally between 2°C and 8°C (refrigerator temperature), ensuring it is not exposed to freezing temperatures. Keep the vials or cartridges in their original packaging to protect them from light and moisture. Do not use the insulin if it has been frozen or if it appears cloudy, discolored, or contains particles. To dispose of any unused or expired insulin, do not throw it in the regular trash or pour it down the sink; instead, follow local guidelines for the safe disposal of medical waste or consult your pharmacist for guidance on proper disposal methods. It is crucial to keep these medications away from children and pets to prevent accidental exposure.

Following are the quick tips for Isophane Insulin Human, Soluble Insulin Human injection:

• Always check the insulin type and strength before injecting to ensure accuracy.
• Rotate injection sites to prevent skin thickening or scarring.
• Inject at room temperature for comfort.
• Dispose of used needles safely in a sharps container.
• Store insulin properly, not freezing or exposing it to extreme heat.
• Never dilute or mix with other insulins unless advised by a healthcare professional.
• Be aware of potential hypoglycemia symptoms and carry a fast-acting carbohydrate source.
• Regularly monitor blood glucose levels as advised by your healthcare provider.