Zatofen (250mg/5ml) 60ml Suspension

Ketotifen, the active ingredient in Ketotifen Syrup/Suspension, primarily acts as a selective histamine H1 receptor antagonist. It exerts its anti-allergic effects by blocking histamine receptors, thereby inhibiting the release of inflammatory mediators from mast cells and basophils. Additionally, Ketotifen stabilizes mast cells, reducing their responsiveness to allergens and other stimuli. This stabilization effect helps prevent the release of histamine and other inflammatory substances, which are key contributors to allergic reactions. By targeting these mechanisms, Ketotifen effectively controls allergic symptoms and provides relief from conditions such as allergic rhinitis and chronic idiopathic urticaria.

Ketotifen

Ketotifen Syrup/Suspension is an antihistamine.

Suspension

The following are the uses of Ketotifen Syrup/Suspension:

• Used for relieving allergic symptoms like sneezing, runny nose, and itching
• Used for preventing asthma attacks triggered by allergies
• Used for treating chronic idiopathic urticaria (CIU), offering relief from hives and itching
• Used for managing allergic conjunctivitis, reducing eye itching and redness
• Used for stabilizing mast cells, preventing the release of inflammatory substances
• Used for providing relief from allergic reactions to food, pets, pollen, and dust mites
• Used for long-term management of allergies, with potential to reduce medication frequency over time

To be taken as per doctor's prescription

In the case of an overdose of Ketotifen Syrup/Suspension, it is important to remain calm and seek medical advice promptly. Common symptoms may include drowsiness, dry mouth, and gastrointestinal discomfort. In more severe cases, respiratory depression, hypotension, and seizures could occur. Treatment involves supportive care, monitoring vital signs, and managing symptoms. Always consult a healthcare professional for guidance in managing overdose situations.

In the case of a missed dose of Ketotifen Syrup/Suspension, it is important to administer the medication as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for the missed one. However, if you frequently miss doses, inform your healthcare provider, as they may provide guidance on how to adjust the dosing schedule to ensure the medication's effectiveness. It is crucial to maintain consistency in giving this medication for optimal results.

To use Ketotifen syrup, measure the prescribed dose using an oral syringe or a measuring cup, shake the bottle well before each use, and administer the medication by mouth, preferably with a meal or a glass of water, following the dosage instructions provided by your healthcare professional.

Following are the conditions when Ketotifen Syrup/Suspension should not be used:

• Do not use if the patient is allergic to ketotifen or any other ingredients in the medication.
• Avoid using it if the patient has a history of severe allergic reactions or anaphylaxis.
• Not suitable for patients with severe liver or kidney disease.
• Contraindicated in patients with a history of porphyria (a disorder affecting the skin and nervous system).
• Should not be used in children under 3 years of age due to potential side effects.
• Do not administer if the patient is currently taking certain medications, such as erythromycin, ketoconazole, or cimetidine, as these can interact with ketotifen.
• Not recommended for patients with a history of epilepsy or other seizure disorders.
• Avoid using it during pregnancy or breastfeeding unless the potential benefits outweigh the risks.

The side effects of Ketotifen Syrup/Suspension may include:

• Drowsiness or sleepiness
• Dry mouth
• Upset stomach
• Dizziness
• Fatigue and weakness
• Skin rash or itching
• Increased appetite and weight gain

Following are the precautions and warnings for Ketotifen Syrup/Suspension:

• Do not administer to infants under 3 months old.
• Avoid use in patients with a history of hypersensitivity or allergic reactions to Ketotifen or any of its excipients.
• Caution is advised in patients with liver or kidney disease, as Ketotifen is metabolized by the liver and excreted by the kidneys.
• This medication may cause drowsiness or dizziness, so patients should avoid driving, operating heavy machinery, or engaging in activities requiring mental alertness until they know how the medication affects them.
• Alcohol consumption should be avoided as it may enhance the sedative effects of Ketotifen.
• Patients with glaucoma or urinary retention should use with caution and under medical supervision.
• Not recommended for use during pregnancy or breastfeeding unless the potential benefits outweigh the risks.
• If symptoms persist or worsen after 3 days of treatment, consult a healthcare professional.

Following are the drug interactions for Ketotifen Syrup/Suspension:

• Avoid concurrent use with alcohol, as it may enhance sedative effects and impair cognitive function.
• Ketotifen can increase the effects of central nervous system depressants like benzodiazepines, opioids, and antipsychotics, leading to increased sedation and respiratory depression.
• The effect of warfarin and other anticoagulants may be altered, potentially increasing the risk of bleeding.
• Ketotifen can inhibit the metabolism of certain medications metabolized by CYP enzymes, including some antidepressants and beta-blockers, leading to increased drug levels.
• It may reduce the effectiveness of ketoconazole and other antifungal medications that rely on gastric acid for absorption.
• Concomitant use with antihistamines or other anticholinergic medications may result in excessive drying of the mouth and eyes.
• Ketotifen may interact with certain asthma medications, such as theophylline, and could potentially alter their effectiveness.

Following are the food interactions to consider with Ketotifen Syrup/Suspension:

• Grapefruit and grapefruit juice consumption should be avoided as they can inhibit the CYP3A4 enzyme, potentially leading to increased Ketotifen levels in the blood and heightened side effects.
• Alcohol intake is not recommended as it may exacerbate the sedative effects of Ketotifen, increasing the risk of dizziness and drowsiness.
• Avoid consuming large amounts of vitamin C-rich foods, such as citrus fruits and broccoli, as they may interfere with the absorption of Ketotifen.
• Ketotifen can be taken with or without food, but it's best to follow the dosing instructions provided by your healthcare professional.
• Avoid caffeine-containing beverages like coffee, tea, and energy drinks, as they may increase the side effects of Ketotifen, including nervousness and insomnia.
• Dairy products may interfere with the absorption of Ketotifen, so it's best to separate the medication from milk, cheese, and yogurt by a few hours.
• Fatty meals may delay the absorption of Ketotifen, so it's advisable to take the medication at least an hour before or after a high-fat meal.
• Always ensure you stay well-hydrated when taking Ketotifen, as proper hydration aids in the medication's effectiveness.

Ketotifen Syrup/Suspension should be stored with caution, ensuring it remains in a cool, dry place, ideally at room temperature, shielded from direct sunlight and moisture. Maintain the medication in its original container, tightly sealed, to prevent contamination. Avoid storage in bathrooms or near heat-emitting appliances like stoves or radiators, as temperature fluctuations can compromise the medicine's integrity. Regularly inspect the expiration date, and when disposing of unused or expired syrup, refrain from flushing it or pouring it down the drain. Instead, seek guidance from a pharmacist or healthcare professional for appropriate disposal practices. Additionally, ensure the medication is kept securely away from children to prevent accidental consumption.

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Following are the quick tips for Ketotifen Syrup/Suspension:

• Administer the syrup as directed by your doctor, following the prescribed dosage and duration.
• Before each use, give the bottle a good shake to ensure proper mixing.
• Offer the syrup with a glass of water to enhance absorption.
• Maintain a consistent dosing schedule by giving the medication at the same time daily.
• Store the syrup at room temperature, away from direct sunlight and moisture.
• Always check the expiration date before administering the medication.
• Contact your healthcare provider if you notice any unusual symptoms or if symptoms worsen.