Zavera SR (240mg) 20 Tablets

Verapamil, a 240mg dose in tablet form, acts as a calcium channel blocker, primarily targeting L-type calcium channels. It exerts its therapeutic effect by binding to these channels, thereby inhibiting the influx of calcium ions into cardiac and smooth muscle cells. This blockage reduces the contractility of cardiac muscle and dilates the coronary arteries, resulting in decreased blood pressure and an increased supply of oxygen-rich blood to the heart. Moreover, verapamil's ability to suppress the conduction of electrical impulses in the heart makes it effective in managing arrhythmias by slowing the heart rate and normalizing its rhythm.

Calcium channel blocker.

Tablet

The following are the uses of Verapamil 240mg Tablet:

• Used for controlling high blood pressure
• Used to treat angina, relieving chest pain and improving exercise tolerance
• Used to prevent migraines by reducing their frequency and severity
• Used in the management of irregular heart rhythms, helping to regulate the heartbeat
• Used to enhance the effects of beta-blockers in heart failure treatment
• Used to relax blood vessels, improving blood flow and reducing strain on the heart
• Used as an alternative treatment for cluster headaches, offering relief from intense pain
• Used to prevent and manage cardiac issues during surgical procedures

In the case of an overdose of Verapamil 240mg Tablets, individuals may experience severe symptoms. These can include a significant drop in blood pressure, leading to dizziness and even fainting. Additionally, an irregular heartbeat, also known as arrhythmia, may occur. Gastrointestinal issues such as nausea, vomiting, and abdominal pain are common. Prompt medical intervention is vital, as overdoses can result in life-threatening complications, particularly for those with pre-existing heart conditions.

In the case of a missed dose of Verapamil 240mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication. It is recommended to set reminders or use a pill organizer to help you remember to take your medication as prescribed.

To take Verapamil 240mg Tablet, swallow the tablet whole with a full glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional, without crushing, chewing, or breaking the tablet.

Here are the conditions or situations when Verapamil 240mg Tablet should not be taken:

• Must not be taken if you have a known allergy to Verapamil or any other calcium channel blockers.
• Avoid if you have a heart condition called 'AV block' (second or third degree) without a pacemaker.
• Do not use if you have a severe heart condition, such as heart failure or unstable angina.
• Not recommended for individuals with a history of heart attack in the last 7 days.
• Contraindicated in patients with a type of irregular heartbeat called 'sick sinus syndrome' without a pacemaker.
• Should not be taken if you have a very slow heart rate (severe bradycardia).
• Avoid if you have a condition called 'left ventricular hypertrophy' (enlarged heart muscle).
• Not suitable for individuals with low blood pressure (hypotension).
• Do not take if you have severe liver disease or liver impairment.
• Avoid if you have severe kidney problems or are on dialysis.

The side effects of Verapamil 240mg Tablet may include:

• Dizziness or lightheadedness
• Fatigue or weakness
• Constipation
• Nausea and vomiting
• Headache
• Low blood pressure (hypotension)
• Palpitations or irregular heartbeat
• Skin rashes or allergic reactions

Following are the precautions and warnings for Verapamil 240mg Tablet:

• Patients with known hypersensitivity or allergy to Verapamil or any of its components should not take this medication.
• Caution is advised for patients with heart conditions such as sick sinus syndrome, AV block, or severe left ventricular dysfunction. Close monitoring is necessary.
• Verapamil can cause a decrease in blood pressure. Patients with hypotension or those taking antihypertensive medications should be monitored for excessive blood pressure drop.
• This medication may affect heart rhythm. Patients with pre-existing heart rhythm disorders should undergo regular ECG monitoring.
• Verapamil can impact liver function. Regular liver function tests are recommended, especially for those with pre-existing liver conditions.
• Elderly patients may be more sensitive to the effects of Verapamil, requiring careful dose adjustment and monitoring.
• Patients should be advised to avoid grapefruit and grapefruit juice as they can affect the metabolism of Verapamil.
• Verapamil may interact with other medications; patients should inform their healthcare provider of all medications they are taking to avoid potential drug interactions.

Following are the drug interactions for Verapamil 240mg Tablet:

• Other calcium channel blockers, beta-blockers, or digoxin can increase the risk of bradycardia and hypotension when combined with Verapamil.
• Verapamil may increase the blood levels of certain statins, leading to increased risk of muscle-related side effects.
• The effectiveness of antihypertensive drugs, such as ACE inhibitors or diuretics, may be enhanced by Verapamil, possibly resulting in excessive blood pressure drop.
• Combining Verapamil with other CYP3A4 inhibitors can increase Verapamil levels, potentially leading to toxicity.
• It may interact with certain antifungal medications like ketoconazole, increasing the risk of cardiac side effects.
• Verapamil can increase the blood levels of immunosuppressants, requiring close monitoring of drug levels.
• The use of Verapamil with some antiarrhythmic drugs may lead to additive effects on heart rate and conduction.

Following are the food interactions for Verapamil 240mg Tablet:

• Grapefruit and grapefruit juice consumption should be avoided as they can significantly increase Verapamil levels in the blood, potentially leading to adverse effects.
• Alcohol should be consumed with caution as it may enhance the sedative effects of Verapamil, increasing the risk of dizziness and drowsiness.
• High-fat meals may slightly delay the absorption of Verapamil but are generally well-tolerated.
• Avoid excessive caffeine intake as it can interact with Verapamil, leading to increased heart rate and blood pressure.
• Foods rich in potassium, like bananas and oranges, should be consumed moderately as Verapamil can cause potassium levels to rise.
• Be cautious with herbal supplements like St. John's Wort, as they may affect Verapamil's metabolism.
• Avoid eating large meals right after taking Verapamil to ensure optimal absorption.
• Always consult your healthcare provider for specific dietary recommendations while on Verapamil therapy.

Verapamil 240mg Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area, away from direct sunlight, moisture, and extreme temperatures. It is crucial to keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent exposure to external factors. Do not store them in the bathroom or kitchen, as humidity and heat can impact their effectiveness. Regularly check the expiration date, and dispose of expired or unused tablets promptly. Proper disposal methods should be followed, avoiding flushing or pouring them down the drain. Consult your pharmacist or local waste management guidelines for appropriate disposal practices. Keep the medication out of children's reach to ensure their safety and prevent accidental consumption.

Following are the quick tips for Verapamil 240mg Tablet:

• Start with a lower dose and gradually increase as directed by your doctor to minimize side effects.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• Take the tablet at the same time each day to maintain consistent blood levels.
• Do not stop taking the medication suddenly, consult your doctor for a proper tapering plan.
• Inform your doctor about all medications you're taking to avoid potential drug interactions.
• Store the tablets at room temperature, away from moisture and direct sunlight.
• Regularly monitor your blood pressure and heart rate while on this medication.