ZEGERID PLUS 40MG TAB

Omeprazole 40mg combined with Sodium Bicarbonate in a tablet formulation has a synergistic mechanism of action for treating acid-related conditions. Omeprazole is a proton pump inhibitor (PPI) that suppresses gastric acid secretion by specifically inhibiting the hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase) enzyme system, also known as the gastric proton pump, in the parietal cells of the stomach. This enzyme is responsible for the final step of gastric acid secretion. Sodium Bicarbonate, on the other hand, acts as an antacid, providing rapid relief by neutralizing existing stomach acid. It helps increase the gastric pH, creating a less acidic environment, which enhances the absorption and effectiveness of Omeprazole. This combination ensures both immediate and sustained relief from excessive acid secretion by addressing the immediate symptoms with Sodium Bicarbonate and reducing acid production over a 24-hour period with Omeprazole.

Proton pump inhibitor, antacid.

Tablet

The following are the uses of Omeprazole 40mg, Sodium Bicarbonate Tablet:

• Used for treating gastroesophageal reflux disease (GERD)
• Used to relieve symptoms of acid reflux and heartburn
• Used for managing symptoms of peptic ulcers
• Used to reduce stomach acid production in conditions like Zollinger-Ellison syndrome
• Used as a short-term treatment for erosive esophagitis
• Used to prevent upper gastrointestinal bleeding in critically ill patients
• Used to improve digestion and reduce acid-related discomfort
• Used in combination with antibiotics to eradicate Helicobacter pylori infection

In the case of an overdose of Omeprazole 40mg and Sodium Bicarbonate Tablets, individuals may experience symptoms such as nausea, vomiting, abdominal pain, and in severe cases, confusion, rapid heartbeat, and seizures. Prompt medical attention is necessary, as treatment may involve supportive care, gastric decontamination, and managing any cardiovascular or neurological complications. It is important to seek professional advice and not delay seeking medical assistance.

In the case of a missed dose of Omeprazole 40mg, it is recommended to take the missed dose as soon as you remember, unless it is almost time for your next scheduled dose. However, if it is close to the time of your next dose, skip the missed dose and continue with your regular dosing schedule. For Sodium Bicarbonate Tablets, if a dose is missed, take it as soon as you remember, but if it is close to the time of your next dose, you may skip the missed dose and continue with your regular dosing regimen. It is important not to double the dose to make up for a missed one.

To take Omeprazole 40mg and Sodium Bicarbonate Tablets, swallow the tablet whole with a full glass of water, preferably in the morning on an empty stomach, at least one hour before a meal, as directed by your healthcare professional.

Following are the conditions or situations when Omeprazole 40mg, Sodium Bicarbonate Tablet should not be used:

• Do not take if you are allergic to Omeprazole, Sodium Bicarbonate, or other proton pump inhibitors (PPIs).
• Avoid using this medication if you have severe liver problems.
• This medication is not recommended for individuals with low magnesium levels or conditions causing low magnesium levels.
• Do not use if you have a rare condition known as Zollinger-Ellison syndrome.
• Contraindicated in patients with an allergy to aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs).
• Should not be used if you are taking certain medications, such as methotrexate or antifungal drugs.
• Avoid taking this medication if you have had a recent heart attack.
• Not suitable for individuals with severe kidney problems.

The side effects of Omeprazole 40mg and Sodium Bicarbonate Tablet may include:

• Headache
• Dizziness
• Diarrhea or constipation
• Abdominal pain
• Nausea and vomiting
• Flatulence (excessive gas)
• Skin rash or itching
• Increased risk of bone fractures with long-term use.

Following are the precautions and warnings for Omeprazole 40mg, Sodium Bicarbonate Tablet:

• Do not take this medication if you are allergic to omeprazole, sodium bicarbonate, or any other similar drugs.
• This medication should be used with caution in patients with liver problems, as it is metabolized by the liver.
• Avoid using this medication if you have low magnesium levels or conditions like osteoporosis, as long-term use may worsen these conditions.
• Do not take this tablet if you have severe kidney problems, as sodium bicarbonate can increase sodium levels.
• Patients with a history of stomach tumors or other gastrointestinal issues should use it with caution and under medical supervision.
• Consult a doctor if you are pregnant, planning to become pregnant, or breastfeeding, as this medication may have potential risks.
• Do not crush or chew the tablet; it should be swallowed whole to ensure optimal effectiveness.

Following are the drug interactions for Omeprazole 40mg and Sodium Bicarbonate Tablets:

• Omeprazole may reduce the absorption of drugs dependent on gastric pH for activation, like ketoconazole, atazanavir, and itraconazole.
• Concomitant use with digoxin can increase its serum concentration, potentially leading to digoxin toxicity.
• May reduce the absorption of drugs like amphetamine, iron, and erlotinib, which require acidic pH for absorption.
• Sodium Bicarbonate can decrease the efficacy of amphetamines, reducing their stimulant effects.
• It may decrease the blood levels of certain medications like lithium, affecting their effectiveness.
• Antacids can interfere with the absorption of quinolone antibiotics, such as ciprofloxacin.
• Omeprazole may interact with clopidogrel, reducing its antiplatelet effect.

Following are the food interactions for Omeprazole 40mg and Sodium Bicarbonate Tablets:

• Avoid excessive consumption of acidic foods like citrus fruits, tomatoes, and spicy dishes, as they can irritate the stomach and potentially reduce the effectiveness of Omeprazole.
• Sodium Bicarbonate can interact with high-sodium foods, increasing sodium levels in the body, so limit salty snacks and processed foods.
• Caffeinated beverages like coffee, tea, and energy drinks may stimulate acid production and should be consumed in moderation.
• Alcohol can increase acid secretion and relax the lower esophageal sphincter, so it's best to limit alcohol intake while taking these medications.
• Avoid carbonated drinks as they can cause gas and bloating, potentially worsening acid reflux symptoms.
• Foods high in fat take longer to digest and can trigger acid reflux, so it's advisable to reduce fatty food consumption.
• Consider limiting chocolate intake as it contains methylxanthines, which can relax the lower esophageal sphincter, leading to increased acid reflux.

Omeprazole 40mg and Sodium Bicarbonate Tablets should be stored in a cool, dry place, preferably at room temperature, ensuring protection from light and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. Avoid exposing the medication to extreme temperatures, such as storing it in the refrigerator, freezer, or near heat sources like ovens or radiators. It is crucial to dispose of any unused or expired tablets responsibly; do not flush them down the toilet or drain. Consult your pharmacist or local waste management guidelines for safe disposal practices. Always keep medications out of children's reach to prevent accidental consumption.

Following are the quick tips for Omeprazole 40mg and Sodium Bicarbonate Tablet:

• Consult your doctor before starting the medication and follow their instructions.
• Swallow the tablet whole; do not crush or chew it.
• Take the tablet on an empty stomach, usually 1 hour before a meal.
• Maintain a consistent daily dose timing for better effectiveness.
• Do not take with other medications without medical advice.
• Inform your doctor about any allergies or medical conditions.
• Store in a cool, dry place, away from direct sunlight.