Zentel (400mg/5ml) 10ml Oral Suspension

Albendazole syrup/suspension works by selectively binding to the colchicine-sensitive site of β-tubulin, which is a major component of microtubules in the cells of susceptible parasites. This binding leads to the inhibition of microtubule polymerization and disruption of the cytoskeleton, resulting in the immobilization and eventual death of the susceptible helminths. The primary effect is on the adult worms, leading to their depletion, while also preventing the development of the larval stages.

Albendazole

Anthelmintic

Suspension

The following are the uses of Albendazole Syrup/Suspension:

• Used for treating intestinal worm infections, such as roundworm and hookworm.
• Used for the treatment of hydatid disease (echinococcosis) caused by tapeworm larvae.
• Used for managing neurocysticercosis, a condition caused by pork tapeworm larvae in the brain.
• Used for eliminating threadworms (pinworms) and other common worm infections.
• Used for treating infections caused by certain types of flukes (flatworms).
• Used for controlling strongyloidiasis, an infection caused by the threadworm Strongyloides stercoralis.
• Used for treating giardiasis, an intestinal infection caused by a microscopic parasite.
• Used for the management of ascariasis, a roundworm infection that can affect the intestines and lungs.

In the case of an overdose of Albendazole Syrup/Suspension, the severity of symptoms can vary depending on the amount ingested. Common signs may include nausea, vomiting, dizziness, and headaches. More severe cases could lead to seizures, difficulty breathing, and loss of consciousness. Prompt medical intervention is necessary, including contacting a healthcare professional or a poison control center for guidance on the appropriate steps to take. Immediate medical care may involve administering activated charcoal or other treatments to mitigate the effects of the overdose.

In the case of a missed dose of Albendazole Syrup/Suspension, it is important to administer the medication as soon as you remember. However, if it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for the missed one, as this may increase the risk of side effects. It is crucial to maintain a consistent dosing routine for Albendazole Syrup/Suspension to ensure its effectiveness in treating the targeted parasitic infections. If you frequently miss doses, consult your healthcare provider for guidance on how to manage the medication schedule effectively.

To administer Albendazole Syrup/Suspension, shake the bottle vigorously, then measure the prescribed dose using an oral syringe or measuring cup, ensuring accuracy, and give it to the patient once or twice daily as directed by the healthcare professional, preferably with a meal.

Following are the conditions/situations when Albendazole Syrup/Suspension should not be used:

• Must not be used in individuals with a known hypersensitivity or allergy to Albendazole or other benzimidazole compounds.
• Contraindicated in patients with known liver disease or impaired liver function.
• Not suitable for individuals with known blood disorders, particularly low white blood cell counts.
• Should not be used during pregnancy, especially during the first trimester, due to potential harm to the developing fetus.
• Contraindicated in patients with known bone marrow suppression.
• Avoid in individuals with a history of seizures or epilepsy, as it may lower the seizure threshold.
• Not recommended for infants under 6 months of age due to the risk of serious side effects.
• Should not be used in patients with known gastrointestinal (GI) obstruction or severe gastrointestinal disorders.

The side effects of Albendazole Syrup/Suspension may include:

• Abdominal pain
• Diarrhea
• Nausea and vomiting
• Headache
• Dizziness
• Temporary hair loss
• Elevated liver enzymes
• Allergic reactions (such as rash, itching, or swelling)

Following are the precautions and warnings for Albendazole Syrup/Suspension:

• Do not use in patients with known hypersensitivity or allergy to albendazole or other benzimidazole compounds.
• Albendazole should be used with caution in patients with liver disease, and regular monitoring of liver function is recommended during treatment.
• This medication may cause dizziness or drowsiness; patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Caution is advised in patients with a history of blood disorders, as albendazole can affect blood cell counts. Regular blood tests may be necessary.
• Albendazole should be used with caution in children, and the dosage should be adjusted according to body weight.
• Pregnant women should not use this medication as it may harm the developing fetus. Effective birth control methods are recommended during treatment.
• It is unknown if albendazole passes into breast milk; breastfeeding mothers should consult a healthcare professional before use.
• Keep out of reach of children and pets.

Following are the drug interactions for Albendazole Syrup/Suspension:

• Dexamethasone may increase the plasma concentration of Albendazole.
• Albendazole may decrease the serum concentration of Praziquantel.
• Concomitant use with Cimetidine may increase the plasma concentration of Albendazole.
• Co-administration with Carbamazepine can decrease the plasma concentration of Albendazole.
• May reduce the efficacy of oral contraceptives, requiring alternative birth control methods.
• Albendazole may decrease the serum concentration of Antacids.
• Co-administration with anti-seizure medications like Phenytoin or Phenobarbital may reduce Albendazole's effectiveness.

Following are the food interactions for Albendazole Syrup/Suspension:

• Avoid consuming grapefruit and grapefruit juice as they can interfere with Albendazole's metabolism, potentially leading to increased drug levels in the body and heightened side effects.
• Alcohol consumption should be avoided as it can enhance the sedative effects of Albendazole, increasing the risk of dizziness and drowsiness.
• Fatty meals may slow down the absorption of Albendazole, potentially reducing its effectiveness. It is advisable to take the medication on an empty stomach or with a light meal.
• Avoid dairy products like milk and cheese within 1-2 hours of taking Albendazole, as calcium can interact with the medication, reducing its absorption.
• Certain high-fat foods like avocado, nuts, and fatty fish may also affect the absorption of Albendazole, so it's best to consult your healthcare provider for specific dietary guidelines.
• Avoid consuming caffeine-rich foods and beverages like coffee, tea, and chocolate, as they may enhance the stimulant effects of Albendazole, potentially causing restlessness and sleep disturbances.
• If you have a diet rich in vitamin C, consider adjusting your intake, as high doses of vitamin C may interact with Albendazole, reducing its effectiveness.
• Always follow the instructions provided by your healthcare provider regarding specific dietary restrictions or recommendations during Albendazole therapy.

Albendazole Syrup/Suspension should be stored in a secure location, preferably in a locked medicine cabinet, at room temperature, away from excessive heat, direct sunlight, and moisture. Ensure the medication is kept in its original container with the cap tightly sealed to maintain its integrity. It is crucial to be mindful of the expiration date on the packaging and promptly discard any unused or expired syrup responsibly. When disposing of the medication, avoid flushing it down the toilet or pouring it into any water source. Instead, consult your local pharmacist or healthcare provider for specific guidelines on safe disposal practices in your area. Additionally, always keep medicines out of children's reach to prevent accidental consumption.

Following are the quick tips for Albendazole Syrup/Suspension:

• Always follow the dosage instructions provided by your doctor or pharmacist.
• Administer the syrup with a measuring cup or oral syringe for accurate dosing.
• Shake the bottle vigorously before each use to ensure a consistent mixture.
• Give the medication at evenly spaced intervals to maintain a constant level in the body.
• Store the syrup in a cool, dry place, away from direct sunlight and moisture.
• Do not freeze the medication, as it may affect its effectiveness.
• Contact your healthcare provider if you notice any unusual or persistent side effects.
• Discard any unused or expired medication as directed by your pharmacist.